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In this study, secretomes from hypoxic mesenchymal stem cells were found to increase PDGF and reduce IL-1β gene expression in rats, potentially offering an effective topical treatment for alopecia caused by long-term fluconazole use.

In this in vitro study, simple centrifugation with calcium gluconate activation led to a significantly higher release of PDGF-BB in PRP compared to other methods, which may inform improved clinical PRP preparation protocols.

This study found that tribuloside, a flavonoid from Tribulus terrestris L., enhances melanin production in human melanocytes, zebrafish, and human skin samples without causing toxicity, potentially through inhibiting PDE to increase cAMP levels and promote the melanin biosynthesis pathway.

This study found that a chitosan/PDRN nanopolyplex significantly improved diabetic wound healing in rats by enhancing cell proliferation, migration, and antimicrobial activities, suggesting its potential as a therapeutic product.

In this study conducted on rabbits, conventional blood treated with 120% sodium citrate was observed to achieve the highest platelet recovery and enrichment coefficient, while altering sodium citrate concentrate affected levels of growth factors PDGF and TGF-β1 after plasma activation.

This pilot study found that using polydioxanone monofilament threads for scalp stringing resulted in significant hair regrowth and increased hair density in male patients with vertex androgenetic alopecia (crown baldness) over six months, showing favorable and promising outcomes.

This study found that 5-alpha reductase inhibitors had the highest association with erectile dysfunction reports among medications analyzed in the FDA's national pharmacovigilance database.

This study found that tadalafil use was associated with a decreased risk of major adverse cardiac events and venous thromboembolism in men with lower urinary tract symptoms.

This study found that testosterone and finasteride were significantly associated with reports of male-factor infertility based on FDA pharmacovigilance data from 2010 to 2020.

This study reports encouraging results in treating androgenetic alopecia by combining injectable PRF and PDO thread insertion on the scalp.

This study found that in 45-year-old German men, the use of metformin, insulin, and ACE inhibitors was associated with lower PSA levels, while low dose finasteride resulted in notable PSA decrease.

This study found that phosphodiesterase inhibitors may suppress the proliferation of benign prostatic hyperplasia epithelial cells by modulating CCL5 levels in low androgen conditions.

PDE inhibitors, especially PDE4 inhibitors like apremilast, are effective for certain inflammatory skin conditions but have side effects and can be costly.

This study found that urologist prescription practices for three common conditions led to nearly $410 million in excess Medicare Part D spending on higher cost and non-generic drugs in 2014.

This study found that men prescribed Finasteride had a lower incidence of bladder cancer compared to those not on the medication, but this protective effect was observed only in Caucasians and Hispanics.

This study found that Pdgfα signaling is crucial for maintaining dermal adipose tissue in mice by initiating dermal adipocyte stem cell proliferation, with implications for age-related skin defects.

IGF-I helps hair growth by preventing cell death and boosting growth factors.

In this study, treatment with a 5a-reductase inhibitor increased CD8+ T cell infiltration in benign prostatic hyperplasia tissues, suggesting an impact on inflammatory responses.

This study observed that long-term treatment with 5ARIs in men with LUTS/BPH was linked to worsening sexual function, whereas doxazosin alone had minimal negative impact.

The researchers found that melatonin implantation in Cashmere goats influenced PDGFA gene expression and hair growth cycles, indicating it may control hair phase transformation from growth to catagen and telogen.

This study found that higher baseline expression of SRD5A2 in prostate tissue was associated with a better response to finasteride in men with benign prostatic hyperplasia.

This study found a significant association between finasteride use and reports of sexual dysfunction, particularly greater in young men using it for alopecia compared to older BPH patients.

This study observed that finasteride therapy reduced PSA levels by about 40% over a year in Chinese patients with benign prostatic hyperplasia, with varying effects based on baseline PSA levels.

This case report describes canities subita, characterized by sudden hair whitening without hair loss, in a patient following a stressful event, suggesting an immune system involvement.

CD8+ T cells re-expressing CD45RA may predict treatment resistance in severe alopecia areata.

In this study, a biocompatible zinc oxide nanocomposite loaded with the anticancer drug 9-Br-Nos demonstrated effective drug delivery and cytotoxicity against lung cancer cells in vitro, while also proving non-toxic to healthy cells, suggesting its potential for targeted lung cancer treatment.

This review summarizes existing literature on PDGF's role in adipose-derived stem cells, highlighting PDGFRβ's functions in inhibiting white adipocyte differentiation and promoting proliferation and angiogenesis.

This study synthesized a temperature-sensitive hydrogel with strong antibacterial capabilities against S. aureus and E. coli, demonstrated via in vitro and in vivo tests, suggesting potential for antibiotic-free clinical applications when activated by near-infrared light.

This study developed and validated an RP-HPLC-PDA method for accurately estimating Tamsulosin and Finasteride in bulk and tablet forms, achieving precise detection and linearity within specified concentration ranges.