40 citations
,
January 2010 in “Indian Journal of Dermatology, Venereology and Leprology” This article reviews the role of diet in various skin disorders and suggests that dietary changes may aid in managing certain conditions, though it reports no new clinical findings.
38 citations
,
September 2021 in “Signal Transduction and Targeted Therapy” This review discusses genetic factors contributing to susceptibility and outcomes in COVID-19, including ACE, ACE2, TMPRSS2 variants, HLA genotype, and ABO blood group, but reports no new experimental results.
38 citations
,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” This article reviews various topics discussed at a workshop on hair disorders, focusing on hair biology, diagnosis, and challenges in therapy evaluation, without presenting new clinical findings.
36 citations
,
June 2021 in “Experimental & Molecular Medicine” This study found that mechanical stress activates a WISP-1/Hedgehog signaling axis that contributes to ligamentum flavum hypertrophy and fibrosis, identifying Hedgehog signaling as a potential therapeutic target.
35 citations
,
March 2007 in “Skin Research and Technology” In this study, researchers developed a non-invasive method to distinguish exogen hair from telogen hair on the human scalp, finding that normal exogen hair levels are generally less than seven hairs per cm².
35 citations
,
January 2012 in “The Journal of Sexual Medicine” This review examines various androgen deprivation therapy methods for advanced prostate cancer, highlighting benefits and potential cardiovascular and sexual adverse effects, but reports no new clinical results.
33 citations
,
February 2021 in “Advanced Pharmaceutical Bulletin” This article explains the preparation methods and applications for various vesicle and particle systems used in transdermal drug delivery, highlighting their effectiveness and potential for further development in this field.
33 citations
,
March 2017 in “Dermatologic Surgery” In this clinical study, low-level laser therapy using the HANDI-DOME LASER device increased hair counts by 51% compared to controls, indicating its potential as a safe and effective treatment for androgenetic alopecia in women aged 18 to 60.
32 citations
,
March 2014 in “PLOS ONE” This study demonstrates that FMOD deficiency in mice alters TGF-β ligand and receptor expression during wound healing stages, leading to delayed wound closure and increased scar size.
32 citations
,
September 1989 in “Medical Clinics of North America” This review describes the types of skin lesions associated with systemic lupus erythematosus, discussing their histopathological features, serologic associations, pathogenesis, and prognostic implications.
30 citations
,
January 2021 in “Journal of Clinical Immunology” This study describes various clinical phenotypes associated with FOXN1 mutations, finding that affected individuals may develop different severities of immunodeficiency based on their genetic mutations.
30 citations
,
April 2020 in “Stem Cell Research & Therapy” This study found that the PI3K-Akt signaling pathway is essential for regenerating new hair follicles when epidermal stem cells and skin-derived precursors are combined, suggesting potential therapeutic applications for hair regeneration.
27 citations
,
August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified 12 new genes associated with the hair follicle and various stages of the hair cycle in mice, which could lead to novel targets for hair growth or depilation therapies.
24 citations
,
January 2019 in “Theranostics” This study found that loss of the Pten gene in Lgr5+ hair follicle stem cells promoted squamous cell carcinoma formation through the Akt/β-catenin signaling pathway.
24 citations
,
January 2006 in “Skin Pharmacology and Physiology” This study found that finasteride (1 mg/day) appeared to reverse the shortening of the hair cycle in androgen sensitive sites but did not convert miniaturized hair into terminal hair.
23 citations
,
March 2019 in “Environmental Chemistry Letters” This review examines the role of cyclodextrins in improving the solubility, stability, and bioavailability of steroid drugs but does not report new experimental findings.
22 citations
,
July 2017 in “BMC complementary and alternative medicine” This study documented the use of 41 plant species in the West Bank for treating hair and scalp disorders, highlighting their folkloric significance and potential for new cosmetic and cosmeceutical products.
22 citations
,
May 2002 in “Skin Research and Technology” This study found that in male androgenetic alopecia, the contrast enhanced phototrichogram technique was superior in detecting changes in hair density and thickness compared to other methods.
20 citations
,
June 2010 in “Genes and Immunity” This study found distinct gene expression patterns in the blood of alopecia areata patients, suggesting involvement of immune processes and new pathways like Wnt signaling and apoptosis in disease pathogenesis.
19 citations
,
June 2015 in “Actas Dermo-Sifiliográficas” This review discusses various skin conditions linked with chronic kidney disease and highlights effective treatments but does not provide new clinical results.
19 citations
,
August 2010 in “Journal der Deutschen Dermatologischen Gesellschaft” This review discusses plant extracts for dermatological use, highlighting evidence that some can reduce edema in chronic venous insufficiency or help treat actinic keratoses, but it reports no new clinical results.
17 citations
,
January 2019 in “International journal of biological sciences” This study found that inserting the Tβ4 gene into cashmere goats increased cashmere yield by 74.5% without compromising quality, suggesting potential economic benefits for goat breeding.
17 citations
,
October 2017 in “Scientific reports” This study found that Super Merino sheep have a higher wool follicle density, finer fleece, and distinct gene expression compared to Small Tail Han sheep, which may inform future breeding and genetic interventions.
16 citations
,
August 2004 in “Tetrahedron” In this study, all stereoisomers of cyoctol were synthesized and tested, revealing that contrary to initial patent claims, cyoctol does not function as an anti-androgen.
14 citations
,
January 2021 in “Cureus” This study suggests that the AndroCoV clinical scoring system may be a more sensitive and cost-effective tool for diagnosing COVID-19 compared to RT-PCR-SARS-CoV-2 tests, potentially reducing diagnostic delays and false negatives.
13 citations
,
May 2022 in “Cell discovery” This study used single-cell RNA sequencing to create a detailed atlas of human scalp hair follicles and found that early-stage hair graying involves matrix hair progenitor depletion linked to P53 pathway activation.
13 citations
,
July 2019 in “Toxicology research” In this study, ethanamizuril was found to cause alopecia, biochemical changes, and organ damage at higher doses in rats, with a no-observed-adverse-effect level of 20 mg/kg over 30 days.
13 citations
,
December 2018 in “Development, Growth & Differentiation” This study found that male and female chicken feather morphology and color patterns can be extrinsically modified through molting and resetting the stem cell niche during regeneration.
13 citations
,
October 2017 in “Bioorganic & Medicinal Chemistry” This study found that compound 3, a tetrahydropyridoindole carboxymethylated at position 5, significantly inhibited sorbitol accumulation in both rat eye lenses and tissues affected by diabetes, indicating its potential as a lead compound for ALR2 inhibition.
12 citations
,
September 2018 in “International Journal of Cosmetic Science” This study demonstrated that the biomimetic peptide PTP20 may help preserve hair pigmentation and reduce greying by enhancing melanocyte function and increasing melanin production in human hair follicles.