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The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

SKPs are similar to adult skin stem cells and could help in skin repair and hair growth.

Super-enhancers controlled by pioneer factors like SOX9 are crucial for stem cell adaptability and identity.

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

Increasing mir-302 turns human hair cells into stem cells by changing gene regulation and demethylation.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

The circadian clock affects skin stem cell behavior, impacting aging and cancer risk.

Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.

TRPA1 is crucial for mechanical sensitivity in skin sensory neurons.

Anti-IL-12/IL-23 antibody therapy effectively treats psoriasiform skin lesions in IBD patients.

Removing part of the vitamin D receptor stops vitamin D from working properly.

Some drugs can cause rare but potentially deadly skin reactions, and early treatment and avoiding the drug again are key.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Growing human skin cells in a 3D environment can stimulate new hair growth.

Human skin can make serotonin and melatonin.

Wnt1/βcatenin signaling is crucial for heart repair after injury.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Ectodin integrates BMP, SHH, and FGF signals in developing ectodermal organs.

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

Fat cells help recruit healing cells and build skin structure during wound healing.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

The Rotterdam Study aims to understand various diseases in older adults.

Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.