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This study found that finasteride reduced prostate cancer incidence by 30%, with no significant difference in Gleason scores compared to placebo after re-evaluation of pathology and extended follow-up.

Dutasteride reduces prostate cancer risk by 23% in high-risk men.

Finasteride lowers prostate cancer risk but may increase high-grade tumors and sexual side effects.

Finasteride is beneficial for BPH but requires careful monitoring due to cancer risks.

This study found that Merkel cell clusters require Frizzled6 signaling for their polarity information, while other hair follicle-associated structures align their orientation based on the hair follicle itself.

This study suggests that simple absolute threshold monitoring rules for compliance using the biomarker DHT perform similarly to more complex methods in the Prostate Cancer Prevention Trial.

This document serves as a resource for pediatricians and primary care providers to guide gender-affirming health care for transgender and gender-diverse youth, including potential medical transition options.

This article from BJU International discusses the slow progress in prostate cancer research and reports no new findings.

Finasteride may reduce prostate cancer risk.

This study found that disruptions in planar cell polarity signaling are implicated in congenital heart defects and cardiomyopathy in developing mouse hearts, associated with early cardiomyocyte disorganization and improper heart looping.

This study found that non-adherence to medication in the Prostate Cancer Prevention Trial was associated with increased all-cause mortality unrelated to prostate cancer.

This article concludes that finasteride is a safe treatment for androgenetic alopecia and does not increase the risk of high-grade prostate cancer, despite past concerns from the Prostate Cancer Prevention Trial.

This study found that patients with androgenetic alopecia had higher symptom-related quality of life impairment than those with alopecia areata, with specific influences from age, disease duration, and severity.

Finasteride is safe for long-term use in prostate cancer treatment.

In this study, dutasteride more effectively reduced prostate cancer cell viability than finasteride in vitro, but did not significantly alter the angiogenic response.

This study found that procyanidins effectively alleviate neuropathic pain in mice by significantly inhibiting MMP-9/2 activity.

This review discusses persistent adverse effects of 5α‐reductase inhibitors, like diminished libido and erectile dysfunction, in some patients and highlights the need for patient discussions before therapy, especially for androgenetic alopecia.

This study suggests that CTHRC1, a protein expressed in cardiac fibroblasts, may improve wound repair and prevent cardiac rupture after myocardial infarction by activating a specific signaling pathway.

This review summarizes existing studies on 5-alpha reductase inhibitors, noting their effectiveness in reducing prostate volume and cancer risk but highlighting an increased risk of higher grade prostate cancer.

This research found that escin, when applied topically, enhances blood flow in human skin and promotes changes in endothelial cell signaling pathways, suggesting potential benefits for improving cutaneous microcirculation.

Finasteride for hair loss may increase the risk of certain cancers and has side effects; better regulation and education on its use are needed.

Dutasteride may help prevent prostate cancer, but more research is needed.

This review discusses preclinical and clinical chemoprevention research for several cancers, noting challenges in effectiveness and toxicity, and emphasizes the need for further trials.

This study used light sheet fluorescence microscopy to successfully image and analyze calcium oscillations in the root hairs of Arabidopsis thaliana, finding that these oscillations correlate with the root hair growth rate and that auxin affects these properties.

This study found that a phosphorus starvation-insensitive mutant of Arabidopsis thaliana shows altered root growth and auxin responses under low phosphate conditions compared to wild-type plants, suggesting a role for LPR1 in regulating these traits.

This study found that overexpressing PLC5 in Arabidopsis thaliana reduced root growth but improved drought tolerance, and suggests PIP2 is crucial for root hair growth.

This paper reports on various AI and human augmentation technologies being applied in plant biology to enhance data processing, improve research efficiency, and enable the discovery of complex biological phenomena that are challenging for humans to perceive or quantify unaided.

This case report describes a 45-year-old woman with an SLE-SSc overlap syndrome who experienced significant improvement in symptoms after tailored immunosuppressive therapy including prednisone and mycophenolate mofetil.

This study found that Filipino patients with lupus typically develop myocarditis early and respond well to early immunosuppressive therapy.

This case report describes a 30-year-old female with overlap syndrome involving systemic lupus erythematosus and scleroderma, where individualized treatment significantly reduced her pericardial effusion.