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In this study, researchers found that the pCLCA2 protein is expressed in specific areas of pig skin, but its role in skin structure or function remains unclear.

This study compared the effectiveness of different thread types in improving collagen profiles in UVB-exposed aging model rats, finding that PCL threads were more effective than PDO and PLLA in enhancing dermal collagen characteristics.

This study reports that multifunctional electrospun scaffolds containing silver vanadate, hydroxyapatite, and graphene oxide significantly improved wound healing in a rat model, promoting rapid re-epithelialization, enhanced mechanical properties, and strong antibacterial activity, making them promising candidates for advanced wound care applications.

This study developed a nanofiber wound dressing combining ciprofloxacin and tetracycline hydrochloride, which demonstrated strong antibacterial activity against E. coli and S. aureus and showed good biocompatibility with human skin fibroblast cells, indicating significant potential for wound healing applications.

This study found that incorporating a block copolymer significantly alters the size and morphology of niosome drug delivery systems made of non-ionic surfactants and cholesterol, affecting their stability.

This study found that PCL-based nanofiber scaffolds enhanced cell proliferation and extracellular matrix deposition, suggesting they show promise as a cell delivery system for improving skin wound healing.

This review discusses the development and future prospects of biomaterials for in situ tissue regeneration but reports no new research results; it underscores the importance of biomaterials in addressing tissue defects.

In this study, microporous electrospun scaffolds pre-seeded with dermal fibroblasts accelerated wound healing and improved dermal matrix structure and hair follicle regeneration compared to acellular scaffolds in a rat model.

This study found that microporous electrospun scaffolds with a 70:30 collagen I to poly(ɛ-caprolactone) ratio significantly accelerated wound closure and dermal regeneration in full-thickness critical-sized skin defects.

This study concluded that polymeric nanoparticles effectively targeted hair follicles for drug delivery, but the organogel formulation did not enhance their penetration into the hair shaft.

In this study, researchers created a novel fibrous membrane inspired by ancient Chinese medicine that effectively promotes hair follicle regeneration and wound healing in deep burn injuries by releasing quercetin, copper, and silicon ions.

In this study, nanocapsule-based preparations containing hinokitiol promoted hair growth in mice comparably to Minoxidil solution, as indicated by photographic and histological analysis.

This study found that electrospun poly(ε-caprolactone)/poly(3-hydroxybutyrate) blend fibers demonstrated nanometric dimensions and promising properties for drug delivery, with curcumin release linked to fiber morphology and processing parameters.

This study developed lipid-core nanocapsules for encapsulating menthol, improving its solubility and thermal stability, and demonstrated their safety and rapid skin absorption in ex vivo tests, highlighting potential applications for cosmeceuticals.

This study demonstrated that a bio-3D printed artificial skin scaffold, seeded with adipose-derived mesenchymal stem cells, showed promising wound healing properties by enhancing cell recruitment, migration, and gene expression related to tissue regeneration.

This study found that gelatin–polycaprolactone/silk fibroin composite membranes with line micropatterns enhanced wound healing in rats by promoting cell alignment, angiogenesis, and increased α-SMA production.

This study explored the development of polymeric nanoparticles for topical spironolactone delivery, finding that larger nanoparticles (180 nm) enhanced drug targeting to hair follicles significantly more than smaller ones or non-nanoparticle formulations, offering promise for safer acne and alopecia treatments.

This review summarizes the promising role of melatonin combined with nanosized carriers in drug delivery, suggesting enhanced effectiveness in treating various diseases compared to free melatonin.

This study found that adapalene-loaded nanospheres in a hyaluronic acid gel enhanced skin penetration and were nonirritant, making them potentially suitable for treating acne on oily skin.

This study reported that a novel trilayer electrospinning wound dressing can improve the wound microenvironment and accelerate repair in abdominal wall defects by facilitating directional biofluid transport and reducing inflammation.

This study found that centrifugally spun scaffolds with higher concentrations of platelet-derived bioactive molecules enhanced melanocyte metabolic activity and proliferation, suggesting potential for improving vitiligo treatment.

In this study, poly (ɛ-caprolactone)–chitosan–poly (vinyl alcohol) nanofibrous scaffolds used on canine skin wound models were found to significantly accelerate healing rates of excision and burn wounds, without inducing immunogenic reactions.

This study found that a novel hydrogel scaffold, cGEL, significantly increased melanin production and melanotic gene expression in human melanocytes compared to other graft materials, suggesting its potential as a superior carrier for skin grafting.

In this study, adipose-derived stem cells from human scalp were successfully directed towards chondrocyte differentiation, with TGF-beta3 and BMP-6 growth factors proving effective for in vitro chondrogenesis.

This review highlights that synthetic biodegradable polymers like PVA, PCL, PLA, PLGA, PU, and PEO/PEG can address the limitations of natural polymers in wound healing, offering improved mechanical properties and slower degradation, thereby enhancing their application as wound dressings.

This study systematically reviews the development and applications of drug-loaded nanofiber scaffolds in wound healing, highlighting challenges such as maintaining drug activity and achieving controlled release, while summarizing preparation methods and describing advanced drug delivery schemes.

This review discusses various microneedle technologies for long-acting drug delivery, highlighting design considerations and challenges in bringing these minimally invasive devices to market, but it reports no new clinical results.

This chapter reviews the use of electrospun matrices in creating tissue-engineered skin substitutes and reports no new clinical results; it emphasizes the need for a cell-friendly microenvironment.

In this study, researchers found that the thyroxine receptor agonist TDM10842 accelerated the onset of anagen, a hair growth phase, in C3H mice, potentially through activation of the Wnt/beta-catenin and Hedgehog pathways, with Pclaf playing a key role in this process.

In this study, a chronotherapeutic bilayer dressing system showed enhanced diabetic wound healing in a model by reducing inflammation through polyphenols and promoting repair with sustained PDGF-BB delivery, leading to faster re-epithelialization and hair follicle regeneration.