18 citations
,
October 2012 in “Dermatologic Clinics” This article discusses primary cicatricial alopecias, a group of rare inflammatory scalp disorders resulting in permanent hair loss, and reports no new findings.
16 citations
,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” This review explores new theories, diagnostic tools, and management strategies for primary cicatricial alopecia but reports no new clinical findings.
12 citations
,
June 2015 in “Dermatology Reports” This study found that discoid lupus erythematous was the most common type of primary cicatricial alopecia, predominantly affecting middle-aged women.
11 citations
,
June 2020 in “Biomedicines” This study concluded that incorporating the percentage of free PSA and urinary markers improves the accuracy of determining the need for prostate biopsy.
9 citations
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February 2022 in “Biomolecules” This review concludes that while many epidemiological studies suggest high alcohol intake is associated with an increased risk of prostate cancer, the evidence may be affected by confounding factors such as diet and lifestyle.
7 citations
,
September 2015 in “Actas Dermo-Sifiliográficas” This article reviews the challenges of treating frontal fibrosing alopecia and the potential role of hair transplantation, noting the lack of effective medical treatments and uncertainty surrounding transplant outcomes.
7 citations
,
January 2013 in “European Urology” This study developed solid lipid nanoparticles for delivering a shRNA-encoding plasmid that effectively reduced 5α-reductase enzyme levels in vitro without significant cytotoxicity, suggesting potential therapeutic applications.
6 citations
,
August 2022 in “Molecules” This study indicates potential differences in the hair spectra of individuals with mood disorders, suggesting a promising, yet preliminary, method for noninvasive prediagnosis.
6 citations
,
August 2004 in “Journal of Chemical Information and Computer Sciences” This study found that certain molecular quantum descriptors can be directly correlated with the biological activity of benzo[c]quinolizin-3-ones, potentially aiding in the identification and design of active compounds.
6 citations
,
January 2007 in “Journal of cutaneous medicine and surgery” This article details the clinical presentation, diagnosis, and treatment options for an Aboriginal Canadian male with perifolliculitis capitis abscedens et suffodiens, without reporting new study results.
5 citations
,
October 2007 in “PubMed” This study discusses the effects of incorporating various amino acids in hair care products, noting improvements in hair surface properties and color retention when integrated with conditioners.
4 citations
,
November 2021 in “Biomedicines” This review discusses the challenges in diagnosing primary cicatricial alopecias and explores how improved communication and digital pathology could enhance diagnosis, but it reports no new clinical results.
3 citations
,
May 2020 in “Acta pharmaceutica” The researchers reported that protocatechuic acid reduced melanin synthesis and enhanced antioxidant activity in cultured human hair follicle melanocytes, indicating potential for skin whitening applications.
3 citations
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August 2019 in “International Journal of Dermatology” In this observational study, dermoscopy was found to be a useful tool in diagnosing lichen planopilaris among patients with primary cicatricial alopecia.
3 citations
,
December 2016 in “Canadian Urological Association journal” This study suggests that male pattern baldness—especially moderate to severe—is an independent risk factor for prostate cancer and high-grade disease in men undergoing prostate biopsy.
3 citations
,
March 2015 in “Journal of the European Academy of Dermatology and Venereology” Some people with primary cicatricial alopecia also have inflammatory bowel disease, suggesting a possible connection.
2 citations
,
January 2024 in “Journal of the American Academy of Dermatology” Treating primary cicatricial alopecia is difficult and requires evidence-based methods.
2 citations
,
March 2022 in “Applied sciences” In this study, Lespedeza bicolor extract was found to enhance dermal papilla cell proliferation and extend the anagen phase in mice, suggesting its potential as a treatment for alopecia.
2 citations
,
March 2012 in “Current opinion in urology” This study suggests that 5-alpha-reductase inhibitors may reduce the rate of clinical progression in men with low-risk prostate cancer who choose active surveillance.
1 citations
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August 2023 in “Clinical, Cosmetic and Investigational Dermatology” In this study, researchers observed that a hidden scalp condition could contribute to acne keloidalis nuchae and potentially other primary cicatricial alopecias, impacting their diagnosis and treatment.
1 citations
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June 2012 in “Actas Dermo-Sifiliográficas” This article discusses primary cicatricial alopecia, highlighting the need for early and precise diagnosis to effectively manage and treat these complex inflammatory hair disorders, but presents no new clinical results.
1 citations
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April 2010 in “Expert Review of Dermatology” This review discusses primary cicatricial alopecias, detailing their classification, pathogenesis, clinical features, histopathologic findings, and treatment, without reporting new experimental results.
July 2026 in “European Urology Focus” This study found a significant association between baldness patterns, particularly vertex and early-onset baldness, and an increased risk of prostate cancer.
In this study, long-term low-dose finasteride use in men with alopecia was associated with a significant reduction in the diagnosis of benign prostatic hyperplasia and prostate cancer, although further research is needed to understand the mechanisms and long-term effects.
January 2026 in “Acta Dermatovenerologica Alpina Pannonica et Adriatica” In this study, cicatricial alopecias were classified by inflammatory cell type and the researchers highlighted that primary cicatricial alopecia's exact causes remain unknown, accounting for 6% of all hair diseases despite its unclear prevalence.
January 2026 in “Dermatologic Therapy” This study suggests that autologous platelet concentrates may improve inflammatory activity, disease control, and hair regrowth in primary cicatricial alopecia, but the evidence is limited by small sample sizes and study quality.
September 2025 in “Surgeries” This review found that hair transplantation in patients with primary cicatricial alopecias is a viable option when the disease is stable, with outcomes varying significantly by subtype.
August 2025 in “Frontiers in Immunology” This study found that patients with primary cicatricial alopecia are at higher risk of developing various comorbidities, including systemic lupus erythematosus, hypothyroidism, and dermatological conditions, compared to controls.
July 2025 in “Cell & Bioscience” Specific immune cells and pathways contribute to hair follicle inflammation and hair loss, suggesting potential treatments for lichen planopilaris.
April 2024 in “Skin health and disease” In this pilot study, participants with lymphocytic primary cicatricial alopecia who applied 6% topical gabapentin solution twice daily for 12 weeks experienced significant symptom reduction, though there was no noticeable change in nerve fibre density or neuropeptide expression.