Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that prostaglandin metabolism enzymes are present in human hair follicles, suggesting a potential role in hair growth and differentiation, with some expression differences between men and women.

This study found that overexpression of Hoxc13 in GC13 mouse models affects hair follicle differentiation by interacting with medulla-specific genes, particularly Foxq1, suggesting a regulatory pathway for medulla differentiation.

This study reports that overexpressing the BMP antagonist noggin in mice inhibits eyelid opening by reducing apoptosis and delaying cell differentiation in the eyelid epithelium.

In this study, blocking the CXCR3 receptor in mice prevented the development of alopecia areata by inhibiting the accumulation of specific T cells in the skin, suggesting a potential therapeutic approach for humans.

In this study, topical application of fibroblast growth factors was found to promote hair growth by inducing and prolonging the anagen phase in telogenic C57BL/6 mice, suggesting potential as hair growth-promoting agents.

This study reports the successful generation of inducible pluripotent stem cells from mesenchymal stem cells derived from human hair follicles, marking a novel method of reprogramming these cells.

This study found that prolactin is a key regulator of keratin expression in human hair follicles, enhancing specific keratin types and influencing epithelial stem cell-associated keratins.

This study found that brain-derived neurotrophic factor (BDNF) inhibited hair shaft elongation and induced premature catagen development in cultured human hair follicles, partially through transforming growth factor β2.

This study suggests that finasteride may reduce the aggressiveness and invasion of prostate tumors, with effects potentially differing based on the androgen responsiveness of the patient's prostate cells.

In this study using a mouse model, the researchers found that platelet-rich plasma significantly increased the number of newly formed hair follicles and decreased the time for hair formation compared to no treatment.

In this study, topical CUR61414 was effective in inhibiting basal cell carcinomas in mice, but no clinical activity was observed in human trials.

This study found that the subtilisin protease Sub3 from Microsporum canis is essential for adherence to the feline epidermis but is not necessary for invading epidermal structures.

This study found that 3D microtissue models of dermal papilla cells can enhance the ability to induce hair-follicle neogenesis in vivo, offering potential for controlled cell production in follicle regeneration.

This research reported that squarticles, nanoparticles made from sebum-derived lipids, enhanced the follicular delivery and skin accumulation of diphencyprone and minoxidil, indicating effective drug deposition with reduced systemic absorption in alopecia treatment.

Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.

This study identified a new genetic locus, ahl4, on distal Chromosome 10 that contributes to the early-onset, severe hearing loss in A/J mice compared to B6 mice.

This review examines the design strategies for creating conductive hydrogels with adjustable properties for various biomedical applications, highlighting their potential for supporting cell growth, wound healing, drug delivery, tissue regeneration, and biosensing.

This study found that the multifunctional FEA-PCEI dressing significantly accelerated wound healing, reduced scar formation, and promoted hair follicle neogenesis while providing antibacterial and anti-inflammatory benefits.

This study found that light stimulation of intrinsically photosensitive retinal ganglion cells in the eyes can activate hair follicle stem cells through a neural circuit involving the sympathetic nervous system.

This study established a new in vitro culture system that supports the growth and dynamic self-organization of hair follicle stem cells and their progeny, promoting a stable population equilibrium.

This study developed thermo-reversible glycol chitosan hydrogels that effectively form and maintain 3D cell spheroids within one day, offering a simplified method for creating biologically realistic cultures for tissue regeneration and drug screening applications.

This study found that IMT-P8, a novel cell-penetrating peptide, effectively facilitated the dermal delivery of proteins and peptides in mouse skin and cell lines, suggesting potential for topical applications in cosmetics and skin diseases.

This study found that overexpression of Wnt1a in bone marrow mesenchymal stem cells enhanced mouse hair follicle regeneration and promoted hair cycling.

This study found that amplifying Wnt signaling, either genetically or through topical application of liposomal Wnt3a, improved skin wound healing in a mouse model.

This review discusses the progress and challenges in delivering CRISPR/Cas9 systems for in vivo genome editing, highlighting current methods and opportunities for future therapeutic applications.

This review discusses the potential of adipose-derived tissue components like nanofat and stem cells for aesthetic rejuvenation, covering their use in hair growth, scar reduction, and more, without reporting new clinical results.

This study suggests that a position effect disrupting TRPS1 expression may be linked to hypertrichosis in both Ambras syndrome in humans and a similar phenotype in Koa mice.

This review discusses various surgical techniques for vitiligo repigmentation, noting that suction blister and split-thickness skin grafting have the highest success rates according to previous analysis, but reports no new results.

This study observed that in aged mouse skin, there was an increase in IL-17-expressing T helper cells, γδ T cells, and innate lymphoid cells, and blocking IL-17 signaling reduced skin inflammation and delayed age-related changes, suggesting it as a potential target to mitigate skin aging.

In this study, a silk-inspired hydrogel system was developed that combines photodynamic therapy and wound healing, which may significantly reduce melanoma recurrence and enhance healing of infected wounds.