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Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

Male and female skin differ in many ways, which could lead to gender-specific skin treatments.

Dermoscopy helps diagnose and manage alopecia areata by showing specific hair changes.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

Fluoxetine was not effective in treating hair-pulling disorder in the short term.

Demodicosis is common and often missed, needing more recognition and treatment in skin care.

Some medicinal plants can help heal wounds and may lead to new treatments.

The conclusion is that accurate diagnosis of different types of hair loss requires good teamwork between skin doctors and lab experts.

Lower doses of treatments for hirsutism and acne in PCOS are effective and cause fewer side effects.

Chemotherapy-induced hair loss significantly affects patients' well-being, and nurses are key in helping them cope, but more research is needed to find effective treatments.

DrugNet effectively identifies new uses for existing drugs and may save resources in drug development.

Some people with pattern hair loss may also have scalp inflammation and scarring similar to lichen planopilaris.

Pig skin is a good substitute for human skin to measure drug absorption, but differences in skin structure and enzymes across species must be considered.

Women with PCOS have overall higher body fat, not abnormal fat placement, and more insulin resistance.

Patients with certain skin symptoms and high ANA titers should be monitored for potential systemic lupus.

5α-reductase inhibitors may prevent prostate cancer but could also raise the risk of more severe cancers.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Surgeons must understand the full care process for gender confirmation surgery to help transgender individuals effectively.

Choosing the right patients, using proper techniques, and having thorough knowledge are key to preventing and managing dermal filler complications.

Oxidative stress contributes to hair graying and loss as we age.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Substances from Chinese medicines show promise for immune support and disease prevention, but the way they are processed affects their effectiveness.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.