90 citations
,
June 2006 in “The American Journal of Dermatopathology” This review outlines the classification, histopathologic presentation, and pathogenetic concepts of scarring and nonscarring alopecias, reporting no new clinical results and emphasizing the need for clinicopathologic correlation.
66 citations
,
July 2010 in “Journal of Proteome Research” This study suggests that an immune response to trichohyalin and keratin 16 may contribute to the pathogenesis of alopecia areata.
65 citations
,
May 2010 in “Current Women's Health Reviews” This review discusses oxidative stress's role in polycystic ovary syndrome and examines various biomarkers to understand its impact on the disorder's pathogenesis, but reports no new clinical results.
60 citations
,
October 2014 in “Journal of the American Academy of Dermatology” This review examines the definition, etiology, pathogenesis, and clinical features of polycystic ovary syndrome but reports no new clinical findings.
51 citations
,
May 1984 in “Journal of the American Academy of Dermatology” In this study, the authors observed that cell-mediated immune mechanisms may be involved in the pathogenesis of benign follicular mucinosis, based on the cellular and immunological characteristics of two patient cases.
50 citations
,
March 2021 in “Annals of Translational Medicine” This study highlights the need for further research on dysregulated immune and fibrotic pathways in morphea to better understand its pathogenesis and develop new biomarkers and therapies.
38 citations
,
July 2009 in “Current opinion in pediatrics, with evaluated MEDLINE/Current opinion in pediatrics” This article reviews recent findings on alopecia areata, highlighting genetic and immune factors in its pathogenesis but reporting no new clinical results; the authors emphasize the need for quality evidence on treatment efficacy.
34 citations
,
February 2016 in “Fertility and Sterility” This study suggests that higher PDCD4 expression may play a significant role in polycystic ovary syndrome pathogenesis through its association with obesity, insulin resistance, lipid metabolism disorders, and increased granulosa cell apoptosis.
29 citations
,
June 2016 in “Experimental Dermatology” This study provides suggestive evidence that duplications in the MCHR2 gene may be involved in the pathogenesis of alopecia areata.
25 citations
,
April 2019 in “Journal of The American Academy of Dermatology” This study discusses the role of CD8+ T-cell and interferon γ signaling in vitiligo's pathogenesis and notes that JAK inhibitors, which are FDA-approved for other autoimmune diseases, may offer a potential treatment path by blocking this pathway.
25 citations
,
July 2013 in “Journal of Dermatological Science” This study suggests that the androgen receptor locus on the X chromosome may play a role in the pathogenesis of early-onset female pattern hair loss.
23 citations
,
September 2020 in “Journal of Dermatological Science” This pilot study suggests that skin-resident γδT-cells may play a significant role in the early stages of alopecia areata pathogenesis, indicating a potential new target for therapeutic management.
22 citations
,
April 1985 in “Australasian Journal of Dermatology” This review discusses the uncommon but potentially serious cutaneous reactions to beta-adrenergic blockers and the uncertain pathogenesis, with no new clinical results reported.
21 citations
,
January 2016 in “Skin appendage disorders” This review proposes a new classification for telogen effluvium, identifying three pathogenetic types with a common feature of profuse hair shedding, but reports no new clinical results.
20 citations
,
November 2005 in “Journal of Investigative Dermatology Symposium Proceedings” This study found that IFN-γ plays a critical role in T cell activation and the pathogenesis of alopecia areata in C3H/HeJ mice.
20 citations
,
December 1995 in “Veterinary Dermatology” This study identified a marked reduction in melanin in the hair of Yorkshire Terriers with Colour Dilution Alopecia and proposed a new pathogenetic mechanism based on these observations.
15 citations
,
December 2016 in “Revista Da Associacao Medica Brasileira” This review examines the literature on polycystic ovary syndrome, focusing on its pathogenesis, diagnosis, and links to cardiovascular and hypertensive disorders, but presents no new clinical findings.
8 citations
,
December 2013 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This review discusses recent advancements made in using mouse models to investigate the genetic complexity and pathogenesis of alopecia areata, emphasizing potential new treatment targets, but it reports no new findings.
6 citations
,
May 2021 in “Stem Cell Reviews and Reports” This study identified and characterized progenitor cells from equine feet that may play a role in the pathogenesis and recovery of laminitis, suggesting potential therapeutic targets for treatment.
6 citations
,
January 2015 in “Journal of The European Academy of Dermatology and Venereology” This review examines various conditions that resemble androgenetic alopecia, analyzing their pathogenesis and highlighting the difficulties they pose for accurate diagnosis and treatment; it reports no clinical results.
5 citations
,
March 2023 in “Archives of dermatological research” This study found that hidradenitis suppurativa is associated with increased serum levels of hypoxia-inducible factor-1α, suggesting its role in the disease's pathogenesis and as a treatment target.
5 citations
,
May 2017 in “Journal of dermatological science” This study reviewed the genetic and phenotypic aspects of Olmsted syndrome, highlighting pathogenic mutations in TRPV3 and MBTPS2 genes and their association with specific skin manifestations like symmetrical keratoderma and hyperkeratotic plaques.
4 citations
,
November 2023 in “Frontiers in immunology” In this narrative review, researchers outlined the role of T cells in the autoimmune pathogenesis of alopecia areata and highlighted ongoing research into therapeutic pathways, beyond current JAK inhibitors, aimed at developing new treatments for the disease.
4 citations
,
June 2022 in “Indian Dermatology Online Journal” This review discusses post-COVID hair loss, attributing it to potential pathogenic factors like cytokines and viral effects, and suggests that full recovery without specific treatment is expected.
4 citations
,
September 2020 in “Frontiers in Microbiology” In this study, algal oligosaccharides effectively countered key factors in androgenetic alopecia pathogenesis, improving hair growth indicators in vitro and in mice.
4 citations
,
August 2013 in “Chinese Medical Journal” This study found that a mutation in the seventh exon of the KRT86 gene plays a major role in the pathogenesis of monilethrix in a Chinese family.
4 citations
,
August 2007 in “Journal of The American Academy of Dermatology” This article discusses various aspects of rhinophyma, including its pathogenesis, differential diagnosis, and treatment options, without presenting new clinical research results.
3 citations
,
May 2024 in “Amino Acids” This review identifies cysteine's central role in hair growth and its potential impact on Alopecia Areata's pathogenesis, suggesting examination of cysteine metabolism might clarify the disease's underlying mechanisms and lead to new treatments.
3 citations
,
January 2017 in “Acta Dermato Venereologica” This study found that a specific T-cell receptor motif associated with lipid-antigen stimulation may play a role in the pathogenesis of folliculotropic mycosis fungoides.
2 citations
,
September 2022 In this study, researchers found that a PER3 gene SNP may be pathogenic for a new subtype of dyschromatosis universalis hereditaria, especially when combined with a SASH1 mutation.