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This study suggests that EDA-A2 induces apoptosis in hair follicles by increasing DKK-1 expression, implicating EDA2R signaling as a potential therapeutic target for androgenetic alopecia.

This study observed that a CARASIL mouse model demonstrated abnormal behavior, vascular and cellular changes, and upregulation of the TGF-β/Smad signaling pathway, indicating its potential involvement in CARASIL pathogenesis.

In this study, OEA was found to significantly enhance sebaceous lipogenesis and potentially reduce inflammation in human sebocytes, suggesting it as a promising candidate for treating skin dryness.

The authors highlighted promising developments in JAK inhibitors as targeted treatments for skin diseases such as atopic dermatitis, psoriasis, and alopecia areata, noting their effectiveness and safety profiles. Recent advances also suggest potential for treating melanoma with these inhibitors.

This study found that co-culturing dermal papilla cells in a 3D structure with adipose-derived stem cells may enhance the expression of hair inductivity markers compared to 2D cultures.

This study found that external light can rapidly activate hair follicle stem cells in animals via a retinal light-sensing pathway linked to the central and autonomic nervous systems.

This review discusses the limitations of animal models, particularly mice, in accurately predicting human skin wound healing outcomes and emphasizes understanding species-specific differences in skin characteristics for better translation to clinical settings.

This review discusses the role of signaling networks in sebaceous gland development and disorders, highlighting recent insights from mouse models and cell line studies, but reports no new experimental results.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

This review discusses the synthesis and biological activities of jasmonates, highlighting their potential as drugs and prodrugs, but reports no new clinical results; further research and trials are anticipated.

This study identified a novel G207E STING mutation associated with severe inflammatory symptoms and suggested that common polymorphisms in TMEM173 and IFIH1 may modify the phenotype in affected individuals.

This study investigated dermal fibroblasts in mouse skin using single-cell RNA sequencing and identified signaling pathways that influence adipogenesis, finding that IL-1-NF-κB promotes, while WNT-β-catenin inhibits, the adipogenic potential of these cells, with implications for wound healing and scar formation.

This study suggests that ROXYs and reactive oxygen species are likely involved in the signaling pathways plants use to respond to nitrate deprivation.

This article discusses the advances in understanding wound-induced hair follicle neogenesis (WIHN) and highlights the roles of specific signaling pathways and cellular plasticity, noting no clinical results but suggesting potential areas for further research.

This article reviews the interaction between sex hormone pathways and morphogenesis-related signaling in epithelial organ development, using a chicken model to propose testable hypotheses, but reports no new clinical results.

This study explored gene expression in Changthangi goats and found that higher expression of keratin-related genes and specific signaling pathways may play a role in the development of Pashmina fiber.

This study found that canine adipose-derived mesenchymal stem cell-derived dermal papilla-like tissues promoted new hair follicle formation and increased vascularization in mice, suggesting potential for hair regeneration.

This study found that inhibiting class I histone deacetylases in postnatal mouse dermal cells preserved their ability to induce hair follicles during culture by increasing specific gene expressions and activating the Wnt signaling pathway.

In this study, fermented herbal extracts promoted hair growth and activated Wnt signaling more effectively than nonfermented extracts in mice, suggesting potential benefits for hair regrowth.

This study compiled an archive of 684 genes associated with monogenic hair disorders, identifying previously unrecognized components of Hippo signaling and proposing a new biologically-grounded disease taxonomy.

This systematic review and meta-analysis found 30 genetic loci associated with skin ageing phenotypes, noting shared biological pathways in aspects like pigmentation and wrinkling; researchers suggest further studies targeting the same SNP across populations could clarify these associations.

This review discusses the role of Janus-kinase inhibitors in treating severe atopic dermatitis and alopecia areata, presenting case studies that show their efficacy and calling for further research on long-term effectiveness and safety.

This study reports that a novel gain-of-function mutation in TMEM173, combined with polymorphisms in TMEM173 and IFIH1, results in a distinct clinical phenotype with features of SAVI, including alopecia and photosensitivity.

This computational study developed a regulatory model linking key genes and miRNAs to cardiac senescence, validated by connecting 94% of these elements to existing cardiac aging research.

Understanding skin structure and development helps diagnose and treat skin disorders.

In this review, the authors discuss various skin conditions linked to hyperandrogenism, such as acne and alopecia, with a focus on androgen-targeted therapies, suggesting these are generally more effective than non-androgen-targeted options.

In this study, researchers found that exosome-like nanoparticles isolated from Polygoni Multiflori Radix can promote hair growth in mice by modulating androgen signaling and gene expression, outperforming Minoxidil in testosterone-induced conditions.

This study highlights that physiotherapeutic methods like low-intensity laser therapy, radiofrequency, and electrical stimulation show promising effectiveness in stimulating hair growth and treating telogen effluvium by enhancing cell activity, ATP synthesis, and transdermal drug delivery.

This literature review examined research on hair follicle biology and hair loss treatments, highlighting the potential of secretome-based therapies, which may enhance hair regeneration and address limitations of treatments like minoxidil and finasteride.

This study suggests that phloroglucinol may enhance anagen signaling and reduce oxidative stress-induced damage in human dermal papilla cells, offering a potential therapy for hair loss.