70 citations
,
December 2008 in “Cancer Research” This study found that activating CXCR2 on ras-transformed keratinocytes promotes migration and tumor development in a mouse skin model.
60 citations
,
October 2020 in “Nature Communications” This study found that small molecule AP-1 inhibitors may selectively target SMO inhibitor-resistant basal cell carcinoma cells characterized by specific markers, potentially enhancing combinatorial cancer therapies.
58 citations
,
November 2020 in “International Journal of Dermatology” COVID-19 may cause a temporary hair loss condition called telogen effluvium in some patients after recovery.
54 citations
,
May 2017 in “Biomedicine & Pharmacotherapy” This review discusses the nutrient profile and potential health benefits of pumpkin and watermelon seeds, concluding they are underutilized and could be developed into various nutraceuticals.
54 citations
,
September 2012 in “Dermatologic Clinics” This review discusses possible medication-induced hair loss and the need to exclude other confounding factors like stress and illness; it reports no new clinical findings and emphasizes careful assessment before attributing hair loss to medications.
41 citations
,
July 2015 in “Current Drug Discovery Technologies” This review discusses various plants and herbal formulations traditionally used for hair growth and notes their potential as safer alternatives to synthetic hair loss treatments, but reports no new clinical results.
39 citations
,
April 2020 in “IntechOpen eBooks” The authors describe drug repurposing as a promising strategy for finding new uses for existing drugs, noting it is efficient, cost-effective, and poses lower risks than traditional drug discovery processes, potentially aiding in the treatment of rare and difficult-to-treat diseases.
39 citations
,
January 2019 in “The World Journal of Men's Health” Testosterone replacement therapy can prevent men from fathering children and should not be used by those wanting to stay fertile.
38 citations
,
March 2012 in “Zhongxiyi jiehe xuebao” This review discusses the pharmacognosy, phytochemistry, and medicinal uses of Cuscuta reflexa but reports no new experimental results.
37 citations
,
April 2002 in “The American Journal of Medicine” St. John's Wort can cause dangerous high blood pressure if taken with certain foods.
36 citations
,
September 2019 in “Journal of Herbal Medicine” This review explores research on nanoformulations for enhancing the topical delivery of herbal medicines, noting potential benefits like improved bioavailability and sustained delivery, and emphasizes the need for safety and toxicity guidelines in developing these novel drug delivery systems.
35 citations
,
October 2017 in “JAMA dermatology” This study recommends limiting routine thyroid function screening to children with alopecia areata who have medical histories of Down syndrome, atopy, or family histories of thyroid disease.
26 citations
,
December 2017 in “Journal of Investigative Dermatology” This study found that the acceleration of endothelial to mesenchymal transition due to loss of Notch signaling led to delayed wound healing and increased scarring in skin wounds.
26 citations
,
November 2012 in “Clinics in Plastic Surgery” This article reviews treatments focused on stimulating collagen synthesis and improving skin appearance through methods like mechanical dermabrasion and laser surgery, but it reports no new clinical results.
26 citations
,
June 2010 in “Acta Pharmaceutica” The researchers reported that they successfully developed and validated RP-HPLC and TLC methods for accurately measuring tamsulosin hydrochloride and finasteride in combination forms.
25 citations
,
December 2021 in “Journal of Medical Virology” This systematic review reports that acute telogen effluvium may occur as a stress-induced hair loss following COVID-19 recovery, with most patients experiencing hair regrowth over time.
24 citations
,
December 2023 in “Gels” In this study, researchers reviewed the progress and challenges in using hydrogels for 3D printing in biomedical applications, highlighting advancements in structural complexity, and identifying ongoing issues like resolution improvement, cell viability, and ethical concerns for clinical use.
20 citations
,
March 2023 in “Drug Delivery and Translational Research” This study found that a lacticin 3147 solid lipid nanoparticle gel demonstrated potent and sustained antimicrobial activity against S. aureus, including MRSA, in ex vivo S. aureus-infected pig skin.
20 citations
,
June 2019 in “Experimental Dermatology” This study identified 14 genes affected by copy number variants that may contribute to alopecia areata, including four genes notably involved in autophagy and chromatin remodeling.
19 citations
,
January 2009 in “Journal of Young Pharmacists” This study found that the alcoholic extract of Eclipta alba exhibited dose-dependent antianaphylactic effects in animal models, possibly due to membrane stabilization and reduced histamine release.
18 citations
,
August 2024 in “eLife” This study investigated immune dysregulation in individuals with Down syndrome and found that treatment with the JAK inhibitor tofacitinib improved skin conditions like alopecia areata and reduced autoimmune markers without severe side effects. Additional research is necessary to understand its broader impacts.
18 citations
,
April 2016 in “The journal of immunology/The Journal of immunology” This study found that mesenchymal cells from different organs exhibit substantial heterogeneity, with thymic mesenchymal cells particularly adapted for interacting with epithelial and hematolymphoid cells in high-apoptosis environments.
18 citations
,
April 2013 in “Inflammatory Bowel Diseases” This review discusses the various potential causes of hair loss in patients with inflammatory bowel disease, including telogen effluvium from disease flares, but provides no prevalence data; the authors outline a practical assessment and management approach.
17 citations
,
January 2014 in “Journal of Oral and Maxillofacial Pathology” This case report establishes the diagnosis of seborrheic keratosis in an elderly Indian woman based on histopathological examination, highlighting its potential to mimic malignant tumors and emphasizing the importance of differential diagnosis.
16 citations
,
June 2017 in “JAMA Dermatology” Thalidomide works best for skin lupus not helped by antimalarials, but has many side effects; other treatments are less effective, especially if patients also have systemic lupus.
15 citations
,
November 2024 in “EClinicalMedicine” This abstract does not report specific study results but describes the funding and collaboration involved in developing the International PCOS Guidelines by multiple health research organizations.
14 citations
,
June 2021 in “British Journal of Dermatology” This article discusses the BIOMAP consortium's efforts in standardizing data for atopic dermatitis and psoriasis research to facilitate personalized medicine, but it presents no new research findings.
14 citations
,
January 2020 in “Research Journal of Pharmacy and Technology” This study found that mesenchymal stem cells from adipose tissue and hair follicles have a similar ability to differentiate into neurons, which could aid in developing therapies for neurological diseases.
14 citations
,
September 2019 in “Eye” This review discusses the evidence for using oral medications to treat central serous chorioretinopathy, highlighting eplerenone as having the most support despite a lack of robust efficacy across studies.
14 citations
,
March 2017 in “Genes and immunity” Certain microRNAs may help treat alopecia areata by targeting immune pathways.