237 citations
,
February 2016 in “Science Translational Medicine” This study found that many effects previously thought to be caused by circadian rhythm disruption in Bmal1 knockout mice are actually due to BMAL1's properties unrelated to its clock function.
78 citations
,
October 2020 in “Experimental Dermatology” This review summarizes 15 years of clinical and experimental research advancements in hidradenitis suppurativa, highlighting its recognition as a uniquely healable inflammatory skin disease but reports no new clinical results.
65 citations
,
January 2013 in “Cochrane library” This review found that infliximab, golimumab, and some forms of radiotherapy significantly improved nail psoriasis compared to controls, although they could have serious adverse effects and are not commonly used specifically for nail issues.
53 citations
,
December 2015 in “JAMA Dermatology” This study found that hirsutism and acanthosis nigricans are the most reliable skin markers for diagnosing polycystic ovary syndrome in women and suggest a need for further evaluation of possible metabolic issues.
52 citations
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March 2016 in “JAMA dermatology” This study found that hirsutism significantly negatively impacts quality of life, with self-assessed severity more strongly linked to quality-of-life impact and depressive symptoms than clinician assessments.
48 citations
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February 2014 in “Fertility and Sterility” This study found that androgenic alopecia is present in 22% of women with polycystic ovary syndrome and is associated with acne and hirsutism, but not with increased biochemical hyperandrogenemia or metabolic dysfunction beyond PCOS.
46 citations
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June 2015 in “Fertility and Sterility” This study found that, among women with polycystic ovary syndrome, insulin resistance was significantly associated with an increased risk of depression, even after accounting for factors like BMI.
31 citations
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January 2014 in “Journal of endocrinological investigation” This study reviewed Woodhouse-Sakati syndrome and found it consistently associated with hypogonadism, decreased IGF1, and frontotemporal alopecia, with additional symptoms like intellectual disabilities and diabetes in some patients.
28 citations
,
April 2013 in “Fertility and Sterility” This study found that Caucasian and Asian women with PCOS in the San Francisco Bay Area had a similar prevalence of androgen excess, including hirsutism, across most measures.
22 citations
,
November 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” This study observed that cathepsin L and transglutaminase 3 colocalize in the human hair bulb and nail matrix, suggesting their involvement in terminal differentiation within these epidermal appendages.
19 citations
,
January 2018 Most people with alopecia areata have nail changes, which are common but don't greatly affect their quality of life.
18 citations
,
May 2017 in “Fertility Research and Practice” This study found that increased ovarian volume is associated with markers of insulin resistance in women with polycystic ovary syndrome, while follicle number was not linked to metabolic risk.
12 citations
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March 2015 in “Pediatric Dermatology” This review discusses diagnostic and management challenges of polycystic ovary syndrome in children and adolescents and reports no new clinical results; it emphasizes early intervention when a provisional diagnosis is suspected.
10 citations
,
April 2018 in “Maturitas” This review discusses hormonal changes during menopause, emphasizing the relative androgen excess and the role of insulin resistance, and reports no new clinical findings.
5 citations
,
January 2016 in “Journal of The American Academy of Dermatology” This review discusses inflammatory and medication-related nephrocutaneous disease associations and emphasizes the importance of timely referral to nephrology for early management, but it reports no new clinical results.
2 citations
,
January 2023 in “Research Square (Research Square)” This study found that obesity, insulin resistance, and hyperandrogenism increase the risk of depression and food cravings in women with PCOS, exacerbating obesity and metabolic syndrome.
2 citations
,
June 2017 in “Journal of The American Academy of Dermatology” This article discusses the uncertainty regarding distinct skin findings and cardiometabolic profiles among PCOS subtypes and reports no new clinical data.
2 citations
,
September 2008 in “Fertility and Sterility” In this study, women with PCOS were at higher risk of depression, particularly those with morbid obesity, but other symptoms like elevated testosterone and skin manifestations were not linked to increased depression risk.
In this review, the authors discuss various skin conditions linked to hyperandrogenism, such as acne and alopecia, with a focus on androgen-targeted therapies, suggesting these are generally more effective than non-androgen-targeted options.
July 2023 in “Medicina Estética Revista Científica de la Sociedad Española de Medicina Estética (SEME)” This study observed that infrared light therapy, alone or combined with hyaluronic acid and calcium hydroxylapatite, effectively improved skin laxity with high patient satisfaction and minimal adverse effects among women aged 37 to 68.
November 2022 in “Journal of Investigative Dermatology” This study developed a chalcone-based molecule that significantly increased tyrosinase inhibition and solubility, showing potential as a safe and effective skin depigmenting and antiaging agent, with supportive epigenetic and antioxidant properties observed in vitro.
January 2019 in “ISGE series” This review discusses the criteria, diagnosis, and treatment options for polycystic ovary syndrome and reports no new clinical results; it highlights the need for further research on causative treatments.
August 2013 in “Fertility and Sterility” This study found that androgenic alopecia is common in polycystic ovary syndrome, correlates with other hyperandrogenism signs, but not with increased biochemical or metabolic risk compared to PCOS alone.
September 2008 in “Fertility and Sterility” This study found that both men and women in infertile couples perceive using donor sperm as more likely to cause stress, marital problems, and a diminished sense of joint parenthood compared to donor eggs.
December 2005 in “Journal of Marine Fisheries” This review discusses the causes and patterns of telogen effluvium and reports no new clinical findings; it highlights spontaneous recovery in many cases despite severe hair loss.
December 2005 in “Journal of Marine Fisheries” This article reviews telogen effluvium, including its causes, presentation, and prognosis, and concludes that while chronic cases may be severe, spontaneous recovery can often occur after many years.
January 2005 in “Journal of Marine Fisheries” Female pattern hair loss is caused by genetics and hormones, leading to hair thinning in women.
January 2004 in “Nederlands Tijdschrift voor Dermatologie & Venereologie” This article reviews female pattern hair loss in women, highlighting its characteristics, treatment options, and the need to differentiate it from other hair loss conditions, and reports no new clinical results.
11 citations
,
July 1984 in “Australian Veterinary Journal” This study found that povidone iodine, thiabendazole ointment, captan ointment, and Burroughs Wellcome Ringworm Ointment were effective against Trichophyton equinum var. autotrophicum in horses, but large-scale use may be limited by practicality and cost.
March 2014 in “Journal of the American Academy of Dermatology” Alopecia areata is relatively common in children, has a variable course, and shows different responses to treatment; thyroid testing is recommended for those affected.