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The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.

Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.

The document concludes that non-binary individuals need compassionate support and recognition in healthcare, without being pathologized.

Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

Androgens can both increase and decrease hair growth in different parts of the body.

Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Androgens, like testosterone, are crucial for early testicular descent in rats.

Flutamide effectively reduced excessive hair growth and improved related symptoms in hirsutism patients without significant side effects.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

Hair loss in men treated best with early medication or transplant, new treatments researched.

Androgens can both stimulate and cause hair loss, and understanding their effects is key to treating hair disorders.

No treatment fully prevents hair loss from chemotherapy yet.

The document concludes that accurate diagnosis and personalized treatment are important for skin problems in women with PCOS.

Genetics and hormones play a role in male and female hair loss, but more research is needed to fully understand it.

Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.

Blocking the virus's entry into cells by targeting certain pathways could lead to early COVID-19 treatments.

Androgenetic alopecia involves genetics, hormones, and can be treated with medications or surgery.

Costunolide may have multiple health benefits, including promoting hair growth and protecting against cancer and diabetes, but more research is needed.

Zinc deficiency in children can cause skin issues and can be serious if not diagnosed and treated properly.

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

Men with coeliac disease may have hormone imbalances that could affect sexual function, but these can improve with better gut health.

Abnormal Hedgehog signaling in blood cancers may help tumors grow and resist chemotherapy, suggesting potential for targeted treatments.

New LPA receptors (LPA4, LPA5, LPA6) have diverse roles in the body.