January 2025 in “Drug repurposing” This study reviewed 16 notable drug repurposing patent applications from 2025, highlighting potential new uses such as guanfacine for autonomic dysfunction and disulfiram for subarachnoid hemorrhage survival, though many disclosures lack peer-reviewed studies and no patents are granted.
September 2021 in “Assay and drug development technologies” This review covers drug repurposing patent applications from April to June 2021, detailing potential new therapeutic uses for existing medications, but reports no new clinical results; the authors highlight novel treatment possibilities and suggest further research.
82 citations
,
January 1997 in “Forensic science international” This article presents a biochemical model to explain how drug molecules are incorporated into hair, highlighting factors such as drug melanin affinity and the role of physico-chemical properties.
October 2008 in “Journal of Intellectual Property Law & Practice” The article concludes that recent legal rulings have strengthened the protection of pharmaceutical patents against generic competition.
This study presents a case where a young male with cryptogenic stroke and patent foramen ovale, using finasteride, experienced symptomatic improvement after PFO closure and discontinuing finasteride, suggesting cardiovascular risks associated with the drug.
3 citations
,
January 2010 in “Ghent University Academic Bibliography (Ghent University)” This article reviews the impact of the 2000 revision of the European Patent Convention on drug patent protection and raises concerns about its effects on generic substitution and healthcare professionals.
9 citations
,
November 2009 in “Recent Patents on Drug Delivery & Formulation” This review discusses various patent articles on microemulsion carriers in drug delivery systems and reports no new empirical findings.
21 citations
,
September 2013 in “Current medicinal chemistry” This study found that co-drugs synthesized from hydroquinone and tranexamic acid improved skin targeting and deposition, with reduced irritation and enhanced efficacy for treating hyperpigmentation.
70 citations
,
September 2017 in “Expert opinion on therapeutic patents” This review examines the patent literature on AKR1C3 inhibitors and suggests that although numerous potent inhibitors exist, further preclinical optimization is necessary before assessing their therapeutic potential in human diseases.
1 citations
,
June 2014 in “Annales de Toxicologie Analytique” This study found that analyzing hair samples in young children for drug exposure can indicate environmental drug exposure or in-utero exposure, but cannot definitively confirm deliberate drug administration.
July 2026 in “The Bioscan.” This review details the process and advantages of drug repurposing, highlighting its potential as a cost-effective and expedited alternative to traditional drug development while summarizing various strategies and successful examples, and exploring related regulatory challenges.
May 2026 in “The Bioscan.” This review discusses the process and advantages of drug repurposing, highlighting its potential to expedite development and improve therapeutic outcomes with examples like sildenafil and metformin.
47 citations
,
November 2012 in “Expert Opinion on Therapeutic Patents” The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.
7 citations
,
April 2017 in “Health Economics, Policy and Law” This review analyzes current patent trends in personalized medicine, suggesting they often privilege the pharmaceutical industry without adequately demonstrating overall public benefit.
17 citations
,
April 2021 in “Biointerface Research in Applied Chemistry” This review discusses nanostructured lipid carriers and their potential applications in pharmaceuticals and food, offering no new clinical findings but highlighting recent advancements and patents.
November 2022 in “Journal of Investigative Dermatology” This review analyzes granted patents for skin bioinks for 3D skin bioprinting from 2017 to 2022 and reports no new clinical results.
14 citations
,
June 2021 in “Expert Opinion on Therapeutic Patents” This review discusses various Wnt pathway modulators developed between 2014 and 2020, highlighting their potential as treatments for diseases like cancer and osteoarthritis, but reports no new clinical results.
This study used R-language data mining to analyze patents of topical Chinese medicine for hair loss, identifying key medication patterns and ingredients in traditional formulations.
4 citations
,
January 2017 in “Indian Dermatology Online Journal” This case study describes severe hypertrichosis in a 3-year-old with alopecia areata after unsupervised use of high-dose topical minoxidil, highlighting the need to avoid such practices in children.
This review highlights the potential of microneedles as a pediatric-friendly method for delivering proteins, vaccines, and diagnostics transdermally, noting their ability to penetrate the skin's barrier and suggesting future applications in other parts of the body.
July 2008 in “Journal of Intellectual Property Law & Practice” This ruling by the UK Court of Appeal allows patents for pharmaceuticals based on new dosing regimens and can override previous decisions to align with European Patent Office practices.
July 2024 in “Journal of Investigative Dermatology” This study examined the market trends for biologics that have lost patent exclusivity and predicted that drugs like adalimumab, once facing competition, could see price reductions and decreased market share, although the impact on accessibility and total patient use remains unclear.
November 2007 in “Journal of Generic Medicines” Europe strengthened medicine regulations, increased protection against counterfeit drugs, and made it tougher to challenge comparative advertising, while also focusing on patent law enforcement and updating plant protection rules.
11 citations
,
August 1997 in “Expert Opinion on Therapeutic Patents” This review discusses nearly 70 patent applications for the treatment of androgenetic alopecia and other hair conditions, highlighting the mechanisms of action explored but reports no clinical results.
January 2023 in “Brazilian Journals Editora eBooks” Passiflora incarnata may help with anxiety but has risks and drug interactions.
There's a genetic link between Fragile X Syndrome and Autism Spectrum Disorder.
6.7% of urine cultures showed hospital-acquired urinary tract infections.
Children used screens more during COVID-19, causing various health complaints.
Autism Spectrum Disorder is often underdiagnosed in females.
Dissociative disorders in childhood sexual abuse victims are more common in males.
Most pregnant teenagers are not dissatisfied with their body image but worry about weight.
Diagnosing tuberculosis after knee surgery is challenging due to non-specific symptoms.
Post-COVID-19 syndrome is more common in older, severely affected patients.
Psychiatrists should be part of pain management teams due to the psychological aspects of pain.
4 citations
,
November 2020 in “Psoriasis : Targets and Therapy” This review discusses the complexities of managing adolescent psoriasis amidst challenges like identity formation and parent-adolescent dynamics, and proposes updated management strategies for 21st-century adolescents, but reports no new clinical results.
44 citations
,
January 2011 in “Journal of biotechnology” This study successfully recreated human hair follicles in vitro, which offers a potential advancement in hair regeneration and understanding the effects of drugs on hair follicles.
November 2008 in “Journal of Generic Medicines” The document updates on EU legal changes, including pharmaceutical patents, class actions in Italy, and various drug-related rulings.
46 citations
,
September 2011 in “Journal of Endocrinology” This study suggests that 5α-reduced glucocorticoids may have anti-inflammatory potential and could serve as biomarkers for liver inflammation in metabolic disease, with implications for drug development.
April 2021 in “Research Square (Research Square)” This study found that the new cocrystal formulation KET-PABA improved the antimycotic efficiency of ketoconazole and induced an anti-inflammatory response without causing skin sensitization in mice.