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The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.

Hedgehog pathway inhibitors can treat certain aggressive cancers but face limitations like resistance and side effects.

Vitamin D is important for skin health, but more research is needed to understand its full effects and treatment potential.

The vitamin D receptor can act without its usual activating molecule, affecting hair growth and skin cancer, but its full range of actions is not well understood.

Taking biotin supplements can cause incorrect thyroid test results, leading to wrong diagnoses.

HSPGs help control stem cell behavior, affecting hair growth and offering a target for hair loss treatments.

The conclusion is that obesity should be managed with a slow, balanced approach to diet and exercise, with medication and surgery as additional options, and education and access to care are important.

Lotion with fucoidan from brown seaweed improved skin and reduced allergy symptoms in mice with dermatitis.

Hormones control reproduction and are crucial for body balance.

Hormone imbalances can cause specific skin changes, which may help in early detection of endocrine disorders.

Hormone imbalances can cause skin diseases, and understanding these links is important for diagnosis and treatment.

Removing part of the vitamin D receptor stops vitamin D from working properly.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

Topical vitamin D is useful for some skin conditions but not effective for others, and more research is needed.

Skin changes can help diagnose and manage endocrine disorders like thyroid problems, diabetes, and adrenal gland conditions.

Thyroid disease can cause skin, hair, and nail problems, and treating the thyroid condition often improves these symptoms.

Some people have genetic mutations that make them resistant to vitamin D, leading to rickets even with enough vitamin D intake.

Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.

Researchers created a mouse model of a type of rickets that does not cause hair loss.

People with alopecia areata often have lower vitamin D levels and more inflammation, suggesting vitamin D might be involved in the condition.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

The Rotterdam Study aims to understand various diseases in older adults.

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

Animal research has greatly advanced dermatology.

Hairless protein can block vitamin D activation in skin cells.

Topical tacalcitol can treat psoriasis by acting directly on skin cells.

Vitamin D levels in hair don't match those in blood, so hair isn't a reliable indicator of Vitamin D status.

As skin cells mature, vitamin D receptor levels decrease while retinoid X receptor α levels increase.