15 citations,
January 2015 in “Skin Pharmacology and Physiology” Parathyroid hormones are important for hair growth, but their use in treating hair loss from chemotherapy is still uncertain.
The conclusion is that endocrinology significantly impacts medicine with various common medications used for treatment.
305 citations,
February 2007 in “Hormone and metabolic research” Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.
171 citations,
July 2007 in “Journal of Investigative Dermatology” A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.
82 citations,
February 2017 in “Cold Spring Harbor Perspectives in Biology” The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.
77 citations,
July 2012 in “Journal of Investigative Dermatology” Wnt10b overexpression can regenerate hair follicles, possibly helping treat hair loss and alopecia.
75 citations,
October 2002 in “Journal of Dermatological Science” Sophora flavescens extract may help hair grow by affecting growth factors and blocking a hair-related enzyme.
73 citations,
September 2003 in “Journal of Pharmacology and Experimental Therapeutics” Hair color loss can indicate the effectiveness of a drug targeting the KIT protein in mice and humans.
68 citations,
April 2014 in “Journal of Molecular Endocrinology” The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.
55 citations,
April 2010 in “Cancer and Metastasis Reviews” TGFβ's manipulation of inflammation and immune cells affects cancer spread, suggesting new treatment strategies and biomarkers.
42 citations,
February 2018 in “International Journal of Molecular Sciences” Minoxidil boosts hair growth by triggering growth factor release from specific stem cells.
40 citations,
December 2019 in “Neurobiology of Stress” Neuroactive steroids show promise for treating mental and neurological disorders by targeting GABA_A receptors.
35 citations,
February 2019 in “Cell Communication and Signaling” BMP6 and Wnt10b control whether hair follicles are resting or growing.
32 citations,
December 1999 in “Journal of Investigative Dermatology Symposium Proceedings” 17-β-Estradiol applied to the skin stops hair growth, while ICI 182 780 helps hair grow in mice.
20 citations,
November 2019 in “Current Opinion in Systems Biology” The document concludes that computational models are useful for understanding immune responses and could improve cancer immunotherapy.
19 citations,
February 2018 in “Lasers in Medical Science” Red light and LED treatments help hair grow by activating a specific cell signaling pathway.
19 citations,
September 2019 in “EMBO molecular medicine” Blocking TSLP reduces skin inflammation and cell overgrowth in psoriasis.
17 citations,
April 2007 in “Kidney international” Vitamin D boosts a specific gene activity in kidney cells that could improve heart and kidney function.
16 citations,
October 2018 in “Biochemical and Biophysical Research Communications” Sildenafil, often used for erectile dysfunction, may help hair growth.
15 citations,
March 2014 in “Biochimica and biophysica acta. Molecular and cell biology of lipids” ACBP is essential for healthy skin and fur by maintaining the skin's barrier function.
13 citations,
January 2018 in “Cellular Physiology and Biochemistry” Fat-derived stem cells can help protect and repair skin stem cells from aging caused by UV light.
11 citations,
March 2008 in “Experimental Dermatology” A substance called compound-1 could help increase hair growth by maintaining prostaglandin levels in hair follicles.
10 citations,
July 2011 in “British Journal of Dermatology” Lower growth factors linked to balding in androgenetic alopecia.
6 citations,
June 2010 in “Fertility and Sterility” Finasteride helps induce ovulation in nonresponder PCOS women.
3 citations,
January 2023 in “Physiological Research” Conditioned media from mesenchymal stem cells show promise for tissue repair and disease treatment, but more research is needed on their safety and effectiveness.
3 citations,
June 2013 in “Genes & development” CaV1.2 helps activate hair follicle stem cells without calcium flux.
2 citations,
December 2019 in “Neurobiology of Stress” Changing allopregnanolone levels in baby rats affects their adult behavior and alcohol use.
2 citations,
January 2014 in “Hair therapy & transplantation” New treatments for hair growth disorders are needed due to limited current options and complex hair follicle biology.
349 citations,
January 2005 in “The FASEB journal” Human skin can make serotonin and melatonin, which help protect and maintain it.
320 citations,
December 2018 in “Frontiers in Immunology” Changing how mesenchymal stromal cells are grown can improve their healing abilities.