2 citations,
November 2022 in “Oxidative Medicine and Cellular Longevity” The study demonstrates that exosomes derived from dermal papilla cells (DPC-Exos) enhance hair follicle stem cell (HFSC) proliferation and inhibit apoptosis through the Wnt3a/β-catenin signaling pathway. Using a coculture system, it was observed that DPCs promote HFSC proliferation, indicated by increased PCNA protein levels. The overexpression of Wnt3a in DPC-Exos upregulated downstream genes in the Wnt/β-catenin pathway, enhancing HFSC proliferation and reducing apoptosis. These findings suggest potential applications in molecular breeding of Angora rabbits and treatments for human hair disorders.
2 citations,
June 2022 in “Cells” The study demonstrates that 3D spheroid cultures of human dermal papilla cells (DPCs) are more effective than 2D cultures for screening hair growth-promoting compounds, specifically minoxidil and 3,4,5-Tri-O-Caffeoylquinic Acid (TCQA). The 3D model better mimics the in vivo environment, enhancing cell-cell and cell-ECM interactions, and upregulating hair growth-associated genes. Minoxidil and TCQA treatments in the 3D system significantly upregulated pathways related to hair growth, cell adhesion, and collagen production, while downregulating genes linked to inflammation and cell division. These findings suggest that 3D spheroid cultures provide a more accurate and efficient platform for evaluating potential hair growth treatments.
2 citations,
June 2022 in “Phytomedicine” The study investigates the effects of the natural product Shi-Bi-Man (SBM) on hair regeneration, focusing on its activation of the FGF pathway in dermal papilla cells. Using C57BL/6 mice, the researchers administered SBM in both freeze-dried powder and solution forms, observing significant hair regrowth without toxicity. The findings suggest that SBM promotes hair growth by triggering the FGF signaling pathway, offering a potential alternative treatment for alopecia with fewer side effects compared to current FDA-approved drugs like finasteride and minoxidil.
2 citations,
April 2021 in “International Journal of Molecular Sciences” The study concluded that changing the culture conditions can cause sika deer skin cells to switch from a flat to a 3D pattern, which is important for creating hair follicles.
2 citations,
July 2020 in “Electromagnetic Biology and Medicine” Low-frequency electromagnetic fields help regenerate hair follicles using a mix of skin cells.
2 citations,
December 2019 in “FEBS open bio” Combining specific inducers helps dermal papilla cells regain hair-forming ability.
2 citations,
July 2019 in “PeerJ” Removing the VDR gene in skin cells reduces their growth and affects hair-related genes.
2 citations,
October 2017 in “Revista Da Associacao Medica Brasileira” Removing p16INK4a from skin cells can lead to faster and more clumped growth, which might help with hair growth.
2 citations,
September 2016 in “Journal of Dermatological Science” Squarticles, tiny particles made from sebum-derived lipids, can effectively deliver minoxidil, a hair growth drug, directly to hair follicles and skin cells, with less skin penetration and more tolerability.
2 citations,
March 2013 in “Phytotherapy Research” Ascorbigen increases hair cell growth in a lab setting but does not prevent hair loss from chemotherapy in mice.
1 citations,
July 2023 in “Journal of Biophotonics” Red light at 8 mW/cm2 most effectively promotes hair cell growth and affects key growth pathways, especially in cells treated with a hair loss-related hormone.
1 citations,
July 2023 in “International Journal of Molecular Sciences” Treating fat stem cells with low oxygen boosts hair growth cell growth through specific signaling pathways.
1 citations,
June 2023 in “Animals” CRABP2 helps increase the growth of cells important for hair growth by activating a specific growth pathway.
1 citations,
April 2023 in “Biomaterials advances” Gellan gum hydrogels help recreate the environment needed for hair growth cell function.
1 citations,
March 2023 in “Applied sciences” Lavender, lemongrass, rosemary, and chamomile essential oils may help protect cells important for hair growth from damage and could promote hair growth.
1 citations,
January 2023 in “Burns and trauma” Tiny particles from 3D-grown skin cells speed up wound healing by promoting blood vessel growth.
1 citations,
November 2022 in “Research Square (Research Square)” A protein called HIF-1a helps control hair growth genes and could be targeted to treat hair loss.
1 citations,
March 2022 in “Journal of Dermatological Science” Adding TERT and BMI1 to certain skin cells can improve their ability to create hair follicles in mice.
1 citations,
February 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” A peptide from hair follicle stem cells promotes hair growth by activating specific skin cells.
1 citations,
January 2022 in “BMC Genomic Data” The study found that androgen receptors in skin cells mainly affect the focal adhesion pathway and control the caveolin-1 gene, with implications for new treatments for related diseases.
Biomimetic dermal papilla spheres can help regenerate hair to some extent.
1 citations,
June 2021 in “Journal of pharmacopuncture” CBD may help restore hair growth-related protein levels in alopecia caused by hormones or other factors.
1 citations,
February 2021 in “Journal of Dermatological Science” The gene LRRC15 is more active in balding areas of the scalp compared to non-balding areas.
1 citations,
December 2019 in “Journal of medicine and life science” Docosahexaenoic acid (DHA) may help hair growth by promoting dermal papilla cell proliferation.
1 citations,
September 2019 in “Journal of Investigative Dermatology” Human hair matrix cells and dermal papilla fibroblasts can form early hair follicle structures but don't produce hair shafts yet.
1 citations,
October 2018 in “Bioscience reports” Annexin A2 isoform 2 helps dermal papillae cells grow, affecting hair growth.
1 citations,
October 2017 in “Journal of Investigative Dermatology” Blocking a specific enzyme can reduce the negative impact of stress hormones on hair growth cells.
1 citations,
October 2017 in “Journal of Investigative Dermatology” Hair care products reduced hair roughness, a combination of Stemoxydine and Resveratrol increased hair density, fermented mackerel oil promoted hair growth, and genes TERT and Bmi-1 helped create new hair follicles.
1 citations,
May 2017 in “Journal of Investigative Dermatology” CCL5 is important for the hair growth potential of human dermal papilla cells.
1 citations,
January 2017 in “Deleted Journal” Orthosiphon stamineus extract can significantly boost hair growth and cell proliferation in hair loss patients.