research Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm
Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.
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research Novel Insights Into the Molecular Mechanisms Underlying Generalized Glucocorticoid Resistance and Hypersensitivity Syndromes
Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.
research Consequences of Steroid-5α-Reductase Deficiency and Inhibition in Vertebrates
Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.
research Group IID, IIE, IIF, and III Secreted Phospholipase A2s
Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.
research Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome KATP Channel Mutations in Intact Cells
Kir6.1 mutations in Cantú syndrome increase channel sensitivity and hyperpolarization, while SUR2B mutations do not.
research Beneficial Effects of Deoxyshikonin on Delayed Wound Healing in Diabetic Mice
Deoxyshikonin helps wounds heal faster in diabetic mice.
research Enzymes
Enzymes play crucial roles in metabolism, health, and disease management.
research Human and Animal Cells Under Influence of Different Lighting and Stimuli
Different light affects cell functions and can help treat skin conditions.
research Overexpression of Nanog in Amniotic Fluid-Derived Mesenchymal Stem Cells Accelerates Dermal Papilla Cell Activity and Promotes Hair Follicle Regeneration
Nanog gene boosts stem cells, helps hair growth, and may treat hair loss.
research Metabolic Syndrome and the Skin: A More Than Superficial Association
Some skin conditions may indicate metabolic syndrome, which could help with early detection and management of related health issues.
research Disturbance of the Circadian System in Shift Work and Its Health Impact
Shift work disrupts the body's natural clock, leading to health problems.
research Harnessing Mesenchymal Aggregation for Engineered Organ-Level Regeneration: Recent Progress and Perspective
Scientists are using clumps of special stem cells to improve organ repair.
research Scientific Opinion on the Tolerable Upper Intake Level for Selenium
Adults should not consume more than 255 micrograms of selenium per day to avoid risk of hair loss and other side effects.
research Association Between Mesenchymal Stem Cells and COVID-19 Therapy: Systematic Review and Current Trends
Using mesenchymal stem cells or their exosomes is safe for COVID-19 patients and helps improve lung healing and oxygen levels.
research Melatonin Induces a Stimulatory Action on the Scrotal Skin Components of Soay Ram in the Non-Breeding Season
Melatonin stimulates the skin components of ram's scrotum during their non-breeding season.
research An Observational Retrospective Evaluation of 79 Young Men with Long-Term Adverse Effects After Use of Finasteride Against Androgenetic Alopecia
Finasteride caused long-term sexual and non-sexual side effects in young men with hair loss.
research Persistent Sexual and Nonsexual Adverse Effects of Finasteride in Younger Men
Finasteride can cause sexual problems and depression in young men.
research Susceptibility Variants on Chromosome 7p21.1 Suggest HDAC9 as a New Candidate Gene for Male-Pattern Baldness
A gene called HDAC9 might be a new factor in male-pattern baldness.
research Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis
Minoxidil affects collagen-related genes, potentially helping treat fibrosis.
research Alopecia Induced by Tumor Necrosis Factor-Alpha Antagonists: Description of 52 Cases and Disproportionality Analysis in a Nationwide Pharmacovigilance Database
Some drugs used to treat inflammation may cause hair loss.
research Convergent Decay of Skin-Specific Gene Modules in Pangolins
Pangolins have lost some skin-related genes, but kept others, showing complex skin evolution.
research Targeting Integrin Pathways: Mechanisms and Advances in Therapy
New therapies are being developed that target integrin pathways to treat various diseases.
research Influence of the Alkylsulfonylamino Substituent Located at the 6-Position of 2,2-Dimethylchromans Structurally Related to Cromakalim: From Potassium Channel Openers to Calcium Entry Blockers?
New compounds similar to cromakalim were less effective at inhibiting insulin release but improved in solubility and one acted as a calcium entry blocker, not a potassium channel opener.
research Mesenchymal Stem Cells From Mouse Hair Follicles Reduce Hypertrophic Scarring in a Murine Wound Healing Model
Mouse stem cells from hair follicles can improve wound healing and reduce scarring.
research Transplantation Immunology: Solid Organ and Bone Marrow
Transplant success has improved with better immunosuppressive drugs and donor matching.
research Introduction to Transplantology
The document concludes that transplantology has evolved with improved techniques and materials, making transplants more successful and expanding the types of transplants possible.
research Calcineurin-Based Immunosuppression in Renal Transplantation: Focus on Efficacy, the Role of Steroids, and Cardiovascular Risk
Tacrolimus causes fewer acute rejections than cyclosporin A in kidney transplants but doesn't necessarily improve kidney function after one year; cardiovascular risks and side effects vary between the two drugs.
research Minoxidil: Mechanisms of Action on Hair Growth
Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.
research Special Collection on Inward Rectifying Potassium Channels
Inward rectifier potassium channels are important in many body functions and diseases, and could be potential drug targets.
research Applications and Implications of Heparin and Protamine in Tissue Engineering and Regenerative Medicine
Heparin and protamine are promising in tissue repair and organ regeneration, including skin and hair.