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Surfactants in spanlastics improve drug delivery by making nanovesicles more flexible and stable for painless administration through the mouth.

Hair restoration surgery is improving, with less painful techniques like FUE and robotic systems, but they can be costly and require training.

Microneedling with platelet-rich plasma can cause temporary, painful lymph node swelling in some patients.

Laser hair removal is safe with the right settings, but side effects like pain and skin changes are more common in darker or tanned skin.

Microneedles improve drug delivery in various body parts, are safe and painless, and show promise in cosmetology, vaccination, insulin delivery, and other medical applications.

Using a patient's own tissue for micro-grafts may effectively treat non-healing leg ulcers and relieve pain.

A wearable cap-like device using light therapy reduced scalp skin lesions by 71% and was painless.

Neurotoxins can affect neurotransmitter release and have potential in treating muscle, pain, and cancer conditions, but more research is needed on how they work.

SLE significantly affects daily life, especially through fatigue and joint pain, highlighting the need for better treatments.

Vulvar acne, also known as "vulvar Fordyce adenitis", is a condition causing painful bumps on the labia, and it's not always effectively treated with common acne medications, but isotretinoin has shown promise.

Local anesthesia, often with sedation, effectively reduces pain in hair transplant harvesting.

Both laser treatments improved acne scars similarly, but the Nd:YAG laser was safer and less painful, while the Er:YAG laser left patients slightly more satisfied.

Combining platelet-rich plasma injections and gel may effectively treat morphea, improving skin elasticity and reducing pain.

Peripheral nerve blocks are a safe and effective way to treat various headaches and provide lasting pain relief.

Acne keloidalis nuchae is a chronic skin condition more common in African men, causing itchy or painful bumps and can lead to permanent hair loss if not treated early.

Combining microneedling with Q-switched laser treatment for tattoo removal did not improve results and caused more pain.

Higher levels of certain nerve-related proteins are linked to hair loss in women with scalp pain.

The chapter concludes that certain skin diseases in bovines cause symmetrical, non-painful lesions and temporary hair loss due to stress.

A new method using Platelet-rich Plasma (PRP) in a microneedle can promote hair regrowth more efficiently and is painless, minimally invasive, and affordable.

Lower finasteride doses had more side effects; dutasteride caused back pain; more research needed on post-finasteride syndrome.

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

Cancer therapy can cause various skin problems, including hair loss, skin darkening, painful hand-foot syndrome, and severe skin damage.

Oral contraceptives provide various health benefits beyond birth control, including managing menstrual issues, skin conditions, pain, and reducing the risk of certain cancers.

Vigilon, a new wound dressing, promotes faster and better healing with less pain.

GLP-1 receptor agonists, like Dulaglutide, Liraglutide, and Semaglutide, have potential benefits beyond the pancreas, including neuroprotection, pain suppression, cardiovascular protection, obesity management, and cancer treatment, but there are concerns about pancreatitis and pancreatic cancer risks.

Both intense pulsed light and long-pulsed diode laser effectively reduced facial hair in women, with no significant difference in satisfaction after 6 months, but intense pulsed light was more painful.

Chlormadinone acetate is a strong, well-tolerated hormone used in birth control and hormone therapy with benefits for menstrual pain and skin conditions.

Woodhouse-Sakati syndrome often causes sexual development issues, hair loss, learning disabilities, deafness, muscle contractions, limb pain, and diabetes.

Subcutaneous contraceptives can cause side effects like menstrual changes, headaches, weight gain, and pain at the implant site.

Platelet-rich plasma (PRP) treatment has been found effective in promoting hair growth for alopecia patients, with minimal side effects like temporary pain and redness.