May 1999 in “Medicine & Science in Sports & Exercise” This case report discusses an elite female gymnast who experienced delayed menarche likely due to exercise-associated amenorrhea and diagnosed wrist conditions, recommending a treatment of reduced weight-bearing and dietary review.
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135 citations
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May 2002 in “Anesthesiology” This review examines current knowledge and treatment strategies for complex regional pain syndrome type I in adults, emphasizing clinical aspects and highlighting the lack of consensus on therapeutic approaches, without presenting new clinical findings.
105 citations
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January 2004 in “The Journal of Urology” This study found that finasteride significantly improved symptoms in CP/CPPS patients, except for voiding, unlike saw palmetto which showed no long-term benefits.
71 citations
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December 2018 in “Journal of Pain Research” This study suggests that controlling variables during platelet-rich plasma preparation and application may improve its reliability and effectiveness in providing long-term relief from chronic pain.
65 citations
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March 1999 in “Urology” This study found that finasteride significantly reduced symptom severity scores in patients with inflammatory chronic pelvic pain syndrome, though its effect on pain was not significant.
50 citations
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April 2021 in “Frontiers in Immunology” This review discusses neuroimmune communication in skin disorders and peripheral neuropathic pain, highlighting the complex interactions between sensory neurons and immune cells; it reports no new clinical results but suggests potential future therapies.
22 citations
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June 2018 in “Journal of Neuroinflammation” This study found that procyanidins effectively alleviate neuropathic pain in mice by significantly inhibiting MMP-9/2 activity.
18 citations
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February 2023 in “Journal of Clinical Medicine” This study reported that neuropathic pain is prevalent in 6.7% of hospitalized COVID-19 patients during the acute phase and 34.3% of long COVID patients, highlighting the need for additional research.
16 citations
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November 2024 in “Human Genetics and Genomics Advances” This study identified 24 independent genetic variations and 127 unique genes associated with nociplastic pain, suggesting it is a complex, heritable trait with links to various cognitive and metabolic pathways.
16 citations
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November 2018 in “The journal of pain/Journal of pain” This study found that in a rat model, 14,15-EET may alleviate central poststroke pain by enhancing thalamic inhibition through neurosteroid signaling, potentially outperforming gabapentin in early-stage treatment.
16 citations
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December 2012 in “The Clinical Journal of Pain” This study found that trichodynia is associated with both peripheral and central sensitization, potentially linked to hair cycle abnormalities and chronic pain through proinflammatory agents.
16 citations
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December 2006 in “Chinese Medical Journal” This case report describes a 12-year-old boy with congenital insensitivity to pain with anhidrosis and progressing acro-osteolysis, highlighting the severe complications and the necessity for early intervention.
12 citations
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August 2021 in “Biomedical Photonics” This study found that patients who received photobiomodulation therapy after septoplasty experienced lower pain levels and improved heart rate variability compared to those who underwent standard postoperative management alone.
11 citations
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October 2002 in “Pharmacology Biochemistry and Behavior” This study found that formalin-induced pain in rats nearly eliminates testosterone in the brain and spinal cord by likely increasing 5α-reductase activity, but normalizes serum levels after 24 hours.
2 citations
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October 2018 in “Journal of Mind and Medical Sciences” This article reviews surgical and medical management strategies for endometriosis-related abdominal-pelvic pain, emphasizing the complexity and ongoing challenges in achieving long-term pain control and disease management.
1 citations
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October 2025 in “Cureus” In this case report, a 30-year-old male with alopecia universalis and autoimmune conditions experienced treatment failure with JAK inhibitors, including ritlecitinib, and developed severe musculoskeletal pain, indicating a potential novel adverse effect that warrants further pharmacovigilance.
1 citations
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October 2024 in “Cureus” This review suggests that platelet-rich plasma injections may be an effective treatment for greater trochanteric pain syndrome, but emphasizes the need for more high-quality trials to confirm these findings.
1 citations
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February 2024 in “Aesthetic Surgery Journal” This study found that laser hair removal results in females were not influenced by hormonal fluctuations during different menstrual cycle phases, although pain tolerance was slightly lower during menstruation without reaching statistical significance.
1 citations
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August 2021 in “Journal of The American Academy of Dermatology” This study investigates the effects of ice cooling and vibration on reducing pain during platelet-rich plasma injections for alopecia, especially due to concerns about lidocaine reducing PRP efficacy.
1 citations
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February 2021 This study observed that using ice pack compression or a vibration anesthesia device reduced pain during inactivated PRP scalp injections in patients with alopecia, suggesting both as inexpensive and accessible pain-relief options.
1 citations
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September 2017 in “Dermatologic Surgery” The cephalic approach for nerve blocks is less painful than the anterior approach during hair restoration surgery.
1 citations
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April 2015 in “Neurology” This study found that hyperpigmented skin changes resembling Schamberg’s purpura occur in areas affected by CRPS and can also appear on mirror-image locations of unaffected limbs, potentially improving with the condition's treatment.
January 2023 in “Brazilian Journals Editora eBooks” Psychiatrists are crucial in pain management teams because they help treat severe pain and related mental health issues.
April 2026 in “International Journal of Research and Review” This article reviews current literature and suggests that managing gout with early urate-lowering therapy, within a 'treat-to-target' strategy, can help prevent systemic complications and address the rising prevalence of hyperuricemia-related diseases.
March 2026 in “Frontiers in Medicine” This study reported that two male patients with diffuse unpatterned alopecia exhibited donor-area involvement in both the vertex and occiput, challenging the assumption of occipital stability for hair transplantation, and showed partial improvement following treatment with oral finasteride and topical minoxidil.
March 2026 in “Journal of Pain” Preoperative stress markers alone don't predict chronic post-surgical pain.
February 2026 in “Journal of Pain Research” Among adult patients undergoing ophthalmic surgery at West China Hospital, the incidence of acute postoperative pain under general anesthesia was 95%, with factors such as age, ethnicity, surgical type, and sleep quality linked to the likelihood of moderate to severe pain, according to this study.
January 2026 in “International Journal of Molecular Sciences” This review suggests that topically applied peptides may offer a promising alternative for managing pain in chronic wounds, with additional potential benefits of anti-inflammatory and regenerative activities, but acknowledges the challenges of delivering these peptides across damaged skin barriers.
December 2025 in “Cureus” This case report highlights the importance of considering SLE in young male patients with unexplained inflammatory musculoskeletal symptoms, as systemic inflammation was identified and symptoms improved with hydroxychloroquine.