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A specific mutation in PA-PLA1α causes abnormal hair growth.

This study reported discovering a novel missense variant in a case of autosomal recessive woolly hair in a 31-year-old Chinese woman, which significantly reduced secretion of the encoded protein, likely leading to disease by impairing its hydrolytic function.

The enzyme PA-PLA1α is important for proper hair follicle development.

This review discusses the role of lysophosphatidic acid in skin physiology and pathology, highlighting its significance in processes like wound healing and hair follicle development, but reports no new clinical findings.

This study identified a missense mutation in the keratin 71 gene as the cause of autosomal dominant woolly hair/hypotrichosis in a Japanese family, marking the first human mutation in KRT71 linked to a hair disorder.

This case report identifies a novel LIPH gene mutation linked to autosomal recessive woolly hair/hypotrichosis in a Japanese boy, expanding the spectrum of known mutations associated with this condition.

This review discusses the pathophysiologic role of lysophosphatidic acid in the skin and reports no clinical results, suggesting pharmacological inhibition as a potential treatment for various skin disorders.

This study found that Merkel cell clusters require Frizzled6 signaling for their polarity information, while other hair follicle-associated structures align their orientation based on the hair follicle itself.

This study found that Celsr1, not Celsr2, is the primary protein involved in establishing planar cell polarity and hair follicle polarization in the epidermis of mice.

This study found that disrupting the inturned gene in developing mouse epidermis halted hair follicle formation due to impaired keratinocyte differentiation, highlighting primary cilia's role in tissue-specific planar cell polarity signaling.

In this study, researchers explored how hair follicle orientation is affected in the rosette fancy mouse and found that a mutation in the PCP gene Fzd6 caused reversed hair orientations in the posterior region, leading to the formation of unique whorls.

This study found that local refinement of hair follicles into higher order patterns can occur without the core planar cell polarity system, but global alignment with body axes requires its function throughout development and regeneration.

This study found that S. rautanenii bark extract has an anti-proliferative effect on D. dorotocephala, suggesting it may have potential anticancer properties when evaluated using inexpensive planaria assays.

This study identified a set of wound-induced genes in planarians that play a role in regeneration initiation, with some genes specifically activating within regenerative cells called neoblasts.

In this study, researchers found that substance P triggered premature catagen development and immune changes in human scalp hair follicles, providing a possible biological link between stress and hair loss conditions like telogen effluvium and alopecia areata.

In this study, researchers found that AGD1 is crucial for membrane recruitment during root hair development in Arabidopsis thaliana, with its pleckstrin homology domain essential for targeting specific plasma membrane regions.

This study found that peroxide-rich plasma-activated water caused minimal morphological damage to hair, while nitrate-rich plasma-activated water induced significant damage, especially in porous hair types.

This study found that disruptions in planar cell polarity signaling are implicated in congenital heart defects and cardiomyopathy in developing mouse hearts, associated with early cardiomyocyte disorganization and improper heart looping.

This research reports that essential oils may enhance athletic performance by improving cerebral hemodynamics and promoting muscle and psycho-emotional relaxation through activation of the limbic system.

In this study, researchers found an increase in daily physical activity during the COVID-19 pandemic among students, with a notable rise in leisure walking and transportation, but also increased weekday sedentary behavior in men.

A specific gene mutation causes woolly hair and hair loss.

This study observed that a combination of micro-needling and low-level light/laser therapy significantly increased hair density in patients with mild to moderate androgenic alopecia, showing an increase of 12 hairs/cm² after 16 weeks, compared to baseline.

This study suggests that fibromodulin may regulate transforming growth factor-β activity during scar formation, influencing the transition from fetal scarless repair to adult scar-forming repair in rats.

This study observed that adding low-level light therapy with the GentleWaves® device to Minoxidil significantly boosted hair regrowth in men with androgenetic alopecia by reducing scalp inflammation.

This review examines the role of nerves in regeneration across various species and discusses their importance as components in the progenitor cell niche, reporting no new clinical results.

This study identified a gene expression signature in mouse embryonic dermal fibroblasts that depends on Wnt/β-catenin activity, potentially influencing dermal fibroblast identity and function.

This study observed that elderly women exhibited a tendency for higher personal anxiety and increased brain DC-potential indicators, with distinct energy cost patterns in different brain regions compared to elderly men.

This case report details two women with female pattern hair loss who experienced severe scalp allergic contact dermatitis from minoxidil, one due to the active ingredient and the other due to the vehicle.

This review suggests that glucagon-like peptide 1 receptor agonists (GLP-1 RAs) have potential benefits for dermatologic conditions but may also cause adverse skin reactions and impact surgical outcomes.

The document discusses various nail and hair disorders and their treatments.