59 citations
,
May 2017 in “Scientific reports” This study found that ZDHHC13 deficiency in mice is associated with abnormal liver function, lipid metabolism issues, and impaired mitochondrial function, highlighting ZDHHC13's regulatory role in liver metabolism.
58 citations
,
September 2012 in “Dermatologic Clinics” This article reviews current knowledge on the causes, diagnosis, and medical treatments for androgenetic alopecia, particularly in men, and reports no new findings.
58 citations
,
January 2006 in “Skin Pharmacology and Physiology” This study found that testosterone and 5α-dihydrotestosterone induced apoptosis in dermal papilla cells from nonbalding scalp regions, suggesting a high androgen stimulus can trigger cell death related to androgenetic alopecia.
58 citations
,
December 2018 in “Nature Communications” This study found that male pattern baldness in European males is strongly heritable and associated with genetic markers linked to earlier puberty, bone density, and pancreatic function.
57 citations
,
November 2017 in “Nature Communications” This genome-wide association study identified 71 genetic loci linked to male pattern baldness, with 30 novel loci, explaining 38% of the risk and suggesting shared pathways with lifespan and cancer traits.
57 citations
,
August 1998 in “The journal of small animal practice/Journal of small animal practice” This study reported that Malassezia-associated dermatitis can cause pruritus in cats with feline paraneoplastic alopecia.
56 citations
,
August 2020 in “American Journal of Clinical Dermatology” This study concluded that the ClinRO and PRO measures, along with their photoguides, offer clear and meaningful assessments for patients with alopecia areata concerning eyebrow, eyelash, and nail appearance, as well as eye irritation.
56 citations
,
July 2004 in “Mechanisms of Development” Pax9 is crucial for proper tongue surface development and preventing skin-like changes.
54 citations
,
January 2012 in “Vitamins & Trace Elements” This study found significantly lower serum vitamin D concentrations in patients with alopecia areata compared to healthy controls, suggesting that vitamin D deficiency may be a risk factor for this autoimmune hair loss disease.
54 citations
,
May 1994 in “Veterinary Pathology” This study found widespread localization of parathyroid hormone-related protein in normal and cancerous canine tissues, suggesting a potential physiological role as a paracrine or autocrine factor.
54 citations
,
January 1986 in “Medical clinics of North America/The Medical clinics of North America” This study reviewed pathology reports of patients with multiple myeloma and found that skin biopsies commonly show graft-versus-host disease, drug-related lesions, and Sweet's syndrome, especially related to transplantation timing.
53 citations
,
August 2019 in “Journal of The American Academy of Dermatology” This study observed that low-dose oral minoxidil and topical minoxidil 5% solution both improved hair density in women with female-pattern hair loss, but oral minoxidil may offer advantages in reducing hair shedding.
53 citations
,
May 2011 in “Dermatologic therapy” This article discusses the pathogenesis and possible biological mechanisms of alopecia areata but reports no new clinical results.
53 citations
,
March 2010 in “British Journal of Dermatology” This study found that androgenetic alopecia is the leading cause of hair loss in adolescents and may indicate endocrine disorders, emphasizing the need for accurate diagnosis.
52 citations
,
May 2011 in “Journal of Neuroendocrinology” This study found that palmitoylethanolamide may stimulate allopregnanolone synthesis and reduce oxidative stress in astrocytes through PPAR-α activation, suggesting a neuroprotective role.
52 citations
,
May 2009 in “Human & experimental toxicology” This study reported that despite treatment, patients with severe thallium poisoning experienced lasting visual impairment and partial recovery of polyneuropathy over two years, with hair loss fully reversing.
52 citations
,
April 2004 in “Journal of The American Academy of Dermatology” This article proposes three mechanisms by which dihydrotestosterone may contribute to baldness but reports no new research findings.
52 citations
,
May 2003 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that overexpression of parathyroid hormone-related protein in mice resulted in 30–40% shorter hair due to premature transition into the catagen phase of the hair cycle.
52 citations
,
January 1999 in “Journal of Small Animal Practice” This case study of a cat with pancreatic carcinoma and paraneoplastic alopecia found that removing the internal tumor reversed hair loss, but symptoms reappeared as the cancer metastasized.
49 citations
,
February 2019 in “The Journal of Clinical Endocrinology and Metabolism” This review offers evidence-based recommendations for diagnosing and treating female pattern hair loss, emphasizing clinical assessment and starting treatment with minoxidil, while noting that measurement of certain hormones and vitamins is optional.
49 citations
,
April 2015 in “Emerging Infectious Diseases” In this study, artesunate was confirmed as an effective treatment for severe malaria, but post-treatment hemolytic anemia occurred, although it was mostly mild and only one transfusion was needed.
49 citations
,
February 2009 in “Clinical Rheumatology” This study observed that systemic lupus erythematosus may not be as uncommon among African Blacks as previously reported, highlighting the need for early aggressive treatment.
48 citations
,
July 1998 in “Pediatric Dermatology” This study found that pulsed doses of prednisolone led to excellent hair growth in 60% of young patients with widespread alopecia areata, with minimal side effects.
48 citations
,
March 1997 in “Veterinary Dermatology” This report describes a paraneoplastic alopecia in four cats associated with internal malignancy, confirming previous findings of a syndrome linking ventral alopecia and metastatic carcinomas.
47 citations
,
May 2020 in “Cardiovascular Research” This review explores how sex differences influence the pathophysiology, incidence, and treatment outcomes of ischaemic heart disease, and emphasizes the need for more sex-specific research.
47 citations
,
November 2012 in “Pharmaceutical research” This study found that surface modified nanoparticles showed increased skin permeation and improvement in allergic contact dermatitis, independent of the follicular pathway.
47 citations
,
June 2011 in “Movement Disorders” The LRRK2-G2019S mutation in Parkinson's disease has a lifetime penetrance of 25-35%, and finasteride may help reduce symptoms in adult male Tourette syndrome patients.
47 citations
,
December 2000 in “Archives of Dermatological Research” This study found that women with androgenetic alopecia showed higher levels of certain hormones and lower levels of sex hormone-binding globulin than healthy controls, potentially linking these factors to alopecia severity.
47 citations
,
January 2016 in “Brain Behavior and Immunity” 5α-reduced progestogens may reduce mood issues and brain damage linked to HIV-1 Tat.
47 citations
,
June 2015 in “Contact Dermatitis” This review discusses the need for an updated 'European hair cosmetic series' to include common contact allergens and remove outdated substances based on current evidence and regulations, but it reports no new results.