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This case report documents a female toddler with novel compound heterozygous mutations in the VDR gene causing hereditary 1,25-dihydroxyvitamin D-resistant rickets, expanding the known mutation spectrum for this disease.

This study identified KRT82 as a significant Alopecia Areata risk gene, finding that rare damaging variants are linked to elevated immune cell infiltration around hair follicles in affected individuals.

This study investigated the phytochemicals in Phyla nodiflora leaf extracts and identified n-Hexadecanoic acid, stigmasterol, and beta-sitosterol as promising drug candidates for diabetes, alopecia, cancer, and anti-diuresis, advocating further research into these compounds.

This study described the diverse vibrissal follicle anatomy in fetuses of three cetacean species and observed species-specific differences, supporting further investigation into vibrissal form and function across cetaceans.

This review discusses the role of extracellular vesicles in bone regeneration and their potential as therapeutics, highlighting challenges like standardization and safety for clinical application, but it reports no new clinical results.

This review discusses using extracellular vesicles as less invasive surrogates for assessing drug-metabolizing enzymes and transporters, suggesting potential advancements in precision therapy, but reports no new clinical results.

This review explores the potential roles of extracellular vesicles in various medical fields, emphasizing their promise but noting the need for standardization and clinical testing before widespread application.

This review discusses the dual role of extracellular vesicles in Alzheimer's disease, highlighting their potential in both exacerbating and alleviating the condition, and emphasizes the need for advanced technologies to enhance diagnosis and treatment.

This paper reviews the emerging potential of menstrual blood-derived mesenchymal stem cell extracellular vesicles in regenerative medicine, highlighting their promise for treating several diseases without providing new clinical results.

This review discusses the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles and modern technologies like 3D bioprinting but reports no new clinical results.

This review discusses the potential of biomimetic synthetic vesicles to advance precision diagnostics and medicine by combining the beneficial properties of naturally occurring extracellular vesicles and synthetic nanoparticles, although no new clinical results are reported.

This review explores current strategies to enhance extracellular vesicle-based delivery of CRISPR/Cas systems, addressing efficiency challenges and suggesting future directions to bridge gene editing technologies with clinical applications.

This review discusses the potential of extracellular vesicles as cell-free tools in tissue engineering and regenerative medicine, noting their emerging role in promoting tissue repair without the risk of host rejection.

This review discusses the role of extracellular vesicles in dermatology for therapeutic, diagnostic, and prognostic purposes, highlighting the lack of validated findings and the necessity for more rigorous clinical trials.

This review explores the potential of extracellular vesicle therapy as a novel strategy to delay intervertebral disc degeneration and enhance tissue repair, by modulating key pathogenic mechanisms, with a focus on the molecular components and bioengineering modifications of extracellular vesicles.

This study demonstrated that a novel hydrogel combining extracellular vesicles from chemically induced mammary epithelial cells with chitosan significantly enhanced skin wound healing in a rat model.

This review analyzed 12 clinical studies on extracellular vesicle therapies, finding potential benefits for skin aging, acne scars, alopecia, and wound healing, but highlighted significant challenges like production standardization and lack of large-scale studies.

In this study, a genetic analysis identified a pathogenic variant in the ALOXE3 gene associated with non-bullous congenital ichthyosiform erythroderma, and the patient's response to antifungal treatment highlights the risk of cutaneous fungal infections.

This review discusses the potential of stem cell-derived extracellular vesicles for improving diabetic wound healing and highlights their mechanisms, limitations, and challenges, but provides no new clinical findings.

This review suggests that extracellular vesicles and conditioned media might be safe and effective for skin rejuvenation and lightening, but further high-quality studies are needed to confirm these findings.

In this study, iPSC-derived epidermal organoids demonstrated potential as a novel tool for regenerative medicine by producing high-performance extracellular vesicles that promote proliferation, migration, and angiogenesis in cell-free therapies for wound healing.

This review found that vesicle-based therapies, including mammalian MSC-derived and plant-derived vesicles, consistently promote wound healing in preclinical models of thermal injury and may offer a safer alternative to live cell transplants.

This study identified specific genetic variants as the cause of visual impairment and non-syndromic alopecia in two brothers, reinforcing the link between PDE6H variants and achromatopsia and LPAR6 variants and alopecia.

This study indicates that while EV-based therapies are advancing towards clinical use in regenerative medicine, addressing methodological and regulatory hurdles is essential to fully harness their therapeutic potential.

In this exploratory randomized controlled trial, participants using a combination of Centella asiatica-derived extracellular vesicles with recombinant growth factors showed significant improvements in hair thickness, density, length, and reduced hair loss and scalp sebum content after 56 days, compared to placebo.

Mesenchymal stromal cell therapies show promise for treating various diseases but need more research and standardization.

This review describes adipose tissue-derived therapies as promising for osteoarthritis, with potential to repair cartilage, reduce inflammation, and enhance joint function, highlighting advancements and their potential future applications.

This study highlights the potential of extracellular vesicles derived from HuMSCs and lncRNA VIM-AS1 to enhance wound healing in diabetic conditions, suggesting innovative strategies for tissue repair.

This review discusses the composition, preparation, and applications of autologous platelet and extracellular vesicle-rich plasma, highlighting its potential benefits and the need for further research, but it reports no new clinical findings.

BOOST is a promising, easy-to-use treatment for diabetic foot ulcers that improves healing by reducing inflammation and promoting blood vessel growth.