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Targeted cancer therapies often cause serious skin problems that need careful management.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Some medicinal plants can help heal wounds and may lead to new treatments.

Certain inhibitors slow down plant growth by causing early cell specialization without changing the cell development pattern.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

Macrophages help heal nerves by aiding the maturation of Schwann cells and are important for nerve repair.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.

Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.

Substances from Chinese medicines show promise for immune support and disease prevention, but the way they are processed affects their effectiveness.

Fat cells in the skin help start healing and form important repair cells after injury.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Male hormones like testosterone may make COVID-19 worse, and testing for sensitivity to these hormones could help predict how severe a patient's symptoms might be. Treatments that reduce these hormones are being explored.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Platelet-rich plasma might help with hair growth and skin conditions, but more research is needed to prove its effectiveness and safety.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

Folliculitis decalvans is a rare scalp condition causing scarring hair loss, treated with long-term antibiotics and other medications, but it often comes back and is hard to manage.

Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

Treating psoriasis on the scalp, nails, and skin folds is challenging, often requiring systemic treatments for severe cases, with some success in topical and biologic treatments.

A mother's PPARγ is crucial for preventing harmful milk that can cause inflammation and growth problems in babies.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.