Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that palmitoylethanolamide may stimulate allopregnanolone synthesis and reduce oxidative stress in astrocytes through PPAR-α activation, suggesting a neuroprotective role.

This review describes how recent discoveries in genetic defects and alternative pathways in androgen biosynthesis are reshaping our understanding of male sexual differentiation, but it presents no new clinical findings.

This study reported that reconstructed skin models can be useful for studying the effects of non-water-soluble topical products on xenobiotic metabolism, particularly in enzyme activities like EROD and GST.

This study found that phenyl-imidazole sulfonamide derivatives, particularly ISCK03, inhibited c-kit signaling and promoted depigmentation in various experimental settings, suggesting potential use as skin-whitening agents.

This study found that the progesterone metabolite 3α-THP increased the proliferation and gene expression of human glioblastoma cells, suggesting a role in tumor progression.

This study demonstrates that locally synthesized estrogen and androgen neurosteroids play opposite roles in long-term synaptic changes in male rats' medial vestibular nucleus, with testosterone-dihydrotestosterone mediating long-term depression and 17β-estradiol mediating long-term potentiation.

This study suggests that neurosteroids, particularly allopregnanolone, may play a crucial role in the progression and management of epilepsy, as indicated by their effects on seizure modulation in both rats and humans.

This study found that a transdermal delivery system using 3% azone and P407 gel may enhance the skin permeation of doxazosin and finasteride for treating benign prostatic hyperplasia.

This study suggests that the progesterone metabolite allopregnanolone and progesterone regulate distinct gene sets involved in glioblastoma cell proliferation, with some overlapping effects modified by finasteride.

This review discusses the role of Cytochrome P-450 in dermatology and reports no new clinical results.

This study reported that in embryo transfer cycles for women with nonclassic 21-hydroxylase deficiency, dexamethasone use was associated with improved pregnancy rates, and maintaining a BMI below 23.36 kg/m² increased pregnancy probabilities.

This study found that glioblastoma cells express key enzymes involved in androgen synthesis, suggesting these enzymes might be potential targets for new therapeutic strategies.

This study found that progesterone and its metabolite, allopregnanolone, provided anti-anxiety and anti-depressive effects in female mice, potentially independent of nuclear progestin receptors but requiring 5α-reduction and estradiol's influence on brain-derived neurotrophic factor.

This study found that the cytochrome P450 enzyme CYP-sb21 can hydroxylate cyclosporine A at multiple positions, reducing its immunosuppressive effects but retaining its hair growth-promoting side-effect, and suggests modifications to improve regioselectivity for commercial use.

This case report describes a rare aggressive variant of squamous cell carcinoma on the scalp of a non-immunosuppressed older male, highlighting its high biological risk for metastasis and poor outcomes.

This study found that progesterone increased the survival of newborn neurons and enhanced spatial learning and memory in adult male mice, independent of neuron production changes.

In this study, intrathecal progesterone administration initially worsened mechanical allodynia in mice after nerve injury, but later reduced pain when applied during the maintenance phase, highlighting distinct roles for cytochrome P450c17 and 5α-reductase in neuropathic pain modulation.

This review discusses the hypotheses surrounding the developmental origins of polycystic ovary syndrome, particularly the role of prenatal androgen exposure, and reports no new experimental results.

This case report describes a rare instance of trichogerminoma with unusually numerous mitotic figures and a higher Ki67 proliferative rate, distinguishing it from previously documented cases.

The conclusion is that managing hair loss conditions like FFA and melanoma requires individualized approaches, considering new findings and balancing treatment benefits with potential risks.

This study found that one month of diabetes altered neuroactive steroid levels and associated mechanisms in the hippocampus and cerebral cortex of an experimental rat model.

This article reviews various aspects of skin cancer, including animal models, molecular mechanisms, immunity roles, and potential chemoprevention strategies, but reports no new experimental results.

This study found that about 80% of known fullerene-binding proteins rank in the top 10% of scorers for C60 docking sites, confirming the accuracy of the predictive model used.

This review suggests that skin may largely protect itself from CYP-generated reactive metabolites due to higher conjugating enzyme activities, while highlighting limitations in modeling human skin metabolism experimentally.

In this study, a patient with cystic fibrosis developed iatrogenic Cushing's syndrome due to impaired clearance of budesonide from concurrent itraconazole use, highlighting the need for regular monitoring in such combination therapies.

In this study, a 9-year-old girl with female pattern hair loss showed clinical improvement and hair regrowth after six months of daily oral spironolactone.

In this study, researchers identified two potential urinary biomarkers, testosterone–glucuronide and 11α-hydroxyprogesterone, along with four candidate biomarkers, to help understand and diagnose polycystic ovary syndrome.

This study discusses clinically relevant interactions between anticancer drugs and herbal medicines used by cancer patients, highlighting potential herb-drug interactions and emphasizing the need for careful monitoring to minimize risks.

In this study, researchers reviewed literature on topical delivery of finasteride for androgenetic alopecia, finding that liposomal gels with specific additives showed the highest skin permeation rates, suggesting potential for reducing systemic side effects compared to oral formulations.

This study found that the dehydroepiandrosterone hydroxylating enzyme system in hair follicles is similar to the liver monooxygenase system, sharing characteristics such as inhibition by carbon monoxide and dependency on NADPH.