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      Transforming Growth Factor-Beta in Stem Cells and Tissue Homeostasis

      research Transforming growth factor-β in stem cells and tissue homeostasis

      245 citations , January 2018 in “Bone Research”
      This review discusses the role of TGF-β signaling in stem cell recruitment and tissue regeneration, indicating that abnormalities in TGF-β activation contribute to various major diseases and suggesting avenues for therapeutic intervention.
      Signaling Involved in Hair Follicle Morphogenesis and Development

      research Signaling Involved in Hair Follicle Morphogenesis and Development

      223 citations , January 2014 in “International Journal of Molecular Sciences”
      This article reviews the complex signaling pathways between epithelial and mesenchymal cells crucial for hair follicle morphogenesis, highlighting the Wnt pathway's role as a master regulator without reporting new experimental findings.
      Epigenetic Control of Adult Stem Cell Function

      research Epigenetic control of adult stem cell function

      179 citations , July 2016 in “Nature Reviews Molecular Cell Biology”
      This review examines how epigenetic dysregulation affects adult stem cell function, noting that impacts range from minor to serious disruptions in tissue homeostasis and potential cancer development.
      A Hot New Twist to Hair Biology: The Role of TRPV1 in Human Hair Growth Control

      research A Hot New Twist to Hair Biology

      174 citations , April 2005 in “˜The œAmerican journal of pathology (Print)”
      This study found that TRPV1 activation in human scalp hair follicles inhibited hair shaft elongation, suppressed proliferation, and induced apoptosis, suggesting TRPV1 as a potential target for managing hair growth and epithelial disorders.
      Wound Healing and the Use of Medicinal Plants

      research Wound Healing and the Use of Medicinal Plants

      170 citations , September 2019 in “Evidence-based Complementary and Alternative Medicine”
      This review discusses the use of 36 medicinal plant species for cutaneous wound healing and reports no new clinical results; the authors highlight the potential for these traditional practices to inform modern therapies.
      Anthracycline Analogs: The Past, Present, And Future

      research Anthracycline analogs The past, present, and future

      168 citations , December 1986 in “Cancer Chemotherapy and Pharmacology”
      Epirubicin is as effective as doxorubicin for cancer treatment with less heart damage, but doesn't work on doxorubicin-resistant cancers.
      Early Inductive Events in Ectodermal Appendage Morphogenesis

      research Early inductive events in ectodermal appendage morphogenesis

      160 citations , January 2014 in “Seminars in cell & developmental biology”
      This review discusses the shared molecular and cellular processes in the early development stages of skin appendages like hair follicles, teeth, and mammary glands, reporting no new results.
      The Hair Follicle as an Estrogen Target and Source

      research The Hair Follicle as an Estrogen Target and Source

      159 citations , July 2006 in “Endocrine Reviews”
      This article discusses the influence of estrogens on hair follicle growth and metabolism, suggesting a significant role alongside androgens in hair growth control but reports no new clinical results.
      The Harmonies Played by TGF-β in Stem Cell Biology

      research The Harmonies Played by TGF-β in Stem Cell Biology

      156 citations , December 2012 in “Cell Stem Cell”
      This review explores the role of TGF-β superfamily pathways in stem cell environments and their implications for tissue regeneration and cancer development, reporting no new experimental results.
      The Immune Functions of Keratinocytes in Skin Wound Healing

      research The Immune Functions of Keratinocytes in Skin Wound Healing

      147 citations , November 2020 in “International Journal of Molecular Sciences”
      This review discusses the immune roles of keratinocytes in wound healing and chronic wound inflammation, emphasizing their potential impact on chronic wound pathology and highlighting areas for future research.
      The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside

      research The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside

      144 citations , November 2020 in “Frontiers in immunology”
      This study summarizes how the IL-23/IL-17 axis contributes to inflammatory skin diseases like psoriasis and highlights that biologics targeting this pathway, including monoclonal antibodies against IL-23 and IL-17, have shown efficacy in clinical trials for these conditions.
      Molecular Mechanisms of Viral Oncogenesis in Humans

      research Molecular mechanisms of viral oncogenesis in humans

      141 citations , August 2018 in “Nature Reviews Microbiology”
      This review discusses the molecular mechanisms by which oncogenic viruses contribute to cancer development through manipulation of host cellular functions and highlights the need for further research into virus-associated cancers, reporting no new results.
      TGF-β Family Signaling in Stem Cells

      research TGF-β family signaling in stem cells

      132 citations , August 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects”
      This review discusses the roles of TGF-β family signaling in regulating normal and cancer stem cells and highlights the need for further research to develop potential cancer treatments; it reports no new results.
      Morpho-Regulation of Ectodermal Organs

      research Morpho-Regulation of Ectodermal Organs

      131 citations , March 2004 in “˜The œAmerican journal of pathology”
      This study found that modulating BMP activity in transgenic mice affects the development and characteristics of several ectodermal organs, such as skin, hair, and claws, highlighting a stage-dependent influence on organogenesis.
      Targeting the Janus Kinase Family in Autoimmune Skin Diseases

      research Targeting the Janus Kinase Family in Autoimmune Skin Diseases

      124 citations , October 2019 in “Frontiers in Immunology”
      This review discusses the role of the JAK-STAT pathway in autoimmune skin diseases and suggests potential therapeutic benefits of JAK inhibitors, but reports no new experimental results.
      From Causes of Aging to Death from COVID-19

      research From causes of aging to death from COVID-19

      122 citations , June 2020 in “Aging”
      This review discusses the hyperfunction theory of aging as a key factor in COVID-19 vulnerability, highlighting the potential of anti-aging interventions like rapamycin to reduce this risk.
      Cell Death in the Skin: Mechanisms and Implications

      research Cell death in the skin

      120 citations , February 2009 in “Apoptosis”
      This review examines apoptotic and anti-apoptotic mechanisms in skin homeostasis and related diseases but presents no new research findings.
      Extraskeletal Actions of Vitamin D

      research Extraskeletal actions of vitamin D

      119 citations , July 2016 in “Annals of the New York Academy of Sciences”
      This review examines the impact of vitamin D signaling in extraskeletal tissues and notes that expected benefits from animal and cell studies have not been consistently replicated in human clinical trials.
      Ultraviolet Radiation in Wound Care: Sterilization and Stimulation

      research Ultraviolet Radiation in Wound Care: Sterilization and Stimulation

      106 citations , July 2013 in “Advances in wound care”
      This review discusses the potential of ultraviolet (UV) radiation technologies in wound care, highlighting their antimicrobial properties and risks of DNA damage, but reports no new clinical findings.