Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that four microRNAs, which were significantly upregulated in balding hair follicle papilla cells, could play a role in the development of male pattern baldness.

This review covers recent developments in inner ear therapeutics and gene delivery methods but reports no new clinical results; it highlights potential strategies for treating hearing and balance disorders.

This review outlines various non-rash skin toxicities associated with novel targeted anticancer therapies and provides guidelines for their early diagnosis and management, but reports no new clinical results.

In this study using genetic mouse models, researchers discovered that senescent melanocytes in nevi secrete osteopontin, which activates hair stem cells, enhancing hair growth; this process is mirrored in human hairy nevi, suggesting a potential therapeutic target for regenerative disorders.

This study found that Undariopsis peterseniana extract may promote hair growth by activating specific cellular pathways, suggesting potential for treating alopecia.

In this review, the authors discuss how understanding and co-regulating multiple signaling pathways could lead to effective regeneration of functional hair cells, highlighting current achievements and future approaches such as small molecule drugs and gene therapy for treating sensorineural hearing loss.

Martin-Perez et al. show that rapamycin's beneficial effects in a mouse model of Leigh syndrome are linked to the downregulation of protein kinase C.

This review discusses the identification and roles of different epidermal stem cell types in skin homeostasis and repair, and reports no new experimental findings.

This review outlines dermatological toxicities associated with targeted cancer therapies and immunotherapies, emphasizing the need for collaborative management by oncologists and dermatologists but reports no new clinical findings.

This review discusses the structure, expression, regulation, and potential roles of NcoA4 in cancer and other pathologies, reporting no new experimental findings.

This review discusses the broader roles of angiogenic factors, like VEGFs and FGFs, beyond angiogenesis, highlighting their involvement in various biological and pathological processes.

In this study, full-size KRT81 was expressed in both normal breast epithelial and breast cancer cells, and contributed to the migration and invasion abilities of breast cancer cells.

This study reported that adipose-derived stem cell-conditioned medium demonstrated anti-tumorigenic effects on B16 melanoma cells both in vitro and in vivo, indicating potential for future melanoma treatment.

In this study, researchers demonstrated that in a mouse model, the stimulation of mammary tumor growth due to progesterone is primarily caused by its metabolite, 5αP, not progesterone itself.

This study found that the small molecule honokiol may protect against inflammation, collagen breakdown, and cell damage caused by cigarette smoke in skin cells cultured in vitro.

This study indicates that the OVOL1-OVOL2 axis may play a significant role in hair follicle differentiation and growth, potentially serving as therapeutic targets for hair disorders like alopecia and in the tumorigenesis of pilomatricoma.

This study reports that in MRL mice, loss of p53 does not impair ear regeneration, suggesting p21's potential role in this process may involve the Tgfb/Smad pathway.

This study found that administering spermidine to aged mice for six months significantly reduced various age-related conditions, including brain, heart, kidney, liver issues, and hair loss, possibly due to decreased telomere attrition.

This study found that deleting the Hes1 gene disrupts hair regeneration by delaying anagen initiation and shortening the anagen phase, suggesting it's crucial for maintaining hair cycle homeostasis.

This review examines how caloric restriction could promote autophagy to rejuvenate aging stem cells, though the precise molecular mechanisms remain unclear.

This study found that mice lacking the type 3 IP(3) receptor in their hair follicles experienced repetitive hair loss and regrowth, indicating disrupted hair-cycle regulation potentially linked to specific signaling pathways.

This study provided the first proteome dataset for alopecia areata, revealing novel pathways in the disease mechanisms that may lead to new therapeutic targets.

This review discusses the cutaneous side effects of chemotherapy, noting that they frequently involve changes to skin, hair, and nails, and reports no new results.

This study found that TSA restored the hair-inductive capacity of skin-derived precursors in mice by enhancing BMP gene expression and signaling through histone acetylation.

The researchers reported that minor salivary gland stem cells exhibit stem cell characteristics and respond to tobacco-derived carcinogens, implicating the transforming growth factor beta pathway in their maintenance.

This review discusses the adverse skin effects of EGFR inhibitors used in cancer treatment, exploring their mechanisms and offering strategies for prevention and management, but reports no new experimental findings.

This study developed a mouse model to monitor hair follicle cycling macroscopically through live bioluminescence imaging, enabling detailed analysis of hair cycle and propagation dynamics influenced by environmental factors.

This study found that Wnt ligands from CD133-positive dermal papilla cells are essential for maintaining hair growth by supporting cell signaling between different hair follicle structures.

This study found that ephrin-A3 accelerates hair follicle development and increases hair follicle density in neonatal mice, suggesting its involvement in hair growth regulation.

This study found that ATM protein plays a crucial role in protecting human hair follicle melanocytes from oxidative stress, which is linked to the greying of hair.