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    Glossary p16

    inhibits cell division by regulating cyclin-dependent kinases

    p16, also known as CDKN2A, is a protein that acts as a tumor suppressor by regulating the cell cycle. It inhibits cyclin-dependent kinases (CDKs), which are enzymes that promote cell division, thereby preventing uncontrolled cell growth that can lead to cancer.

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    Research 30 of 633

    1. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated with p16INK4a Expression Journal of Investigative Dermatology · 2007 · 141 citations
    2. Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16 Stem Cells and Development · 2016 · 83 citations
    3. Expression of vascular endothelial growth factor, apoptosis inhibitors (survivin and p16) and CCL27 in alopecia areata before and after diphencyprone treatment: an immunohistochemical study British Journal of Dermatology · 2004 · 58 citations
    4. Knockout of p16INK4a promotes aggregative growth of dermal papilla cells Revista Da Associacao Medica Brasileira · 2017 · 2 citations
    5. P166 Real-world efficacy and tolerability of oral dutasteride combined with oral minoxidil for male androgenetic alopecia: a retrospective cohort study British Journal of Dermatology · 2026
    6. P164 Cutaneous toxicities occurring during amivantamab treatment: the experience of a single large specialist institution British Journal of Dermatology · 2026
    7. P165 Real-world experience of ritlecitinib for the treatment of alopecia areata from an alopecia clinic in a large tertiary dermatology centre British Journal of Dermatology · 2026
    8. P164 : The effect of ceramide-based essence cream for the damaged hair shaft 프로그램북(구 초록집) · 2018
    9. P165 : Efficacy and safety of adipocyte-derived stem cell conditioned media in the treatment of androgenic alopecia 프로그램북(구 초록집) · 2018
    10. P167 : Protective effect of Korean Red Ginseng on the chemotherapy induced alopecia 프로그램북(구 초록집) · 2015
    11. 138: Induction of cellular senescence and hair follicle stem cell dysfunction upon p14ARF and p16Ink4a expression in the skin European Journal of Cancer · 2014
    12. Decreased expression of cytokeratin 15 and tropoelastin in men with androgenetic alopecia and its relationship with increased expression of p15/p16 Archives of Medical Science · 2020
    13. P163 : Clinical efficacy of 2.5mg/day finasteride in female pattern hair loss 프로그램북(구 초록집) · 2015
    14. New case of trichorinophalangeal syndrome-like phenotype with a de novo t(2;8)(p16.1;q23.3) translocation which does not disrupt the TRPS1 gene BMC medical genetics · 2014 · 9 citations
    15. Molecular Regulation of Melanocyte Senescence Pigment Cell Research · 2002 · 85 citations
    16. Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage PLOS ONE · 2013 · 30 citations
    17. Epimorphic regeneration in mice is p53-independent Cell Cycle · 2010 · 20 citations
    18. Human Papillomavirus E6/E7 Oncogenes Promote Mouse Ear Regeneration by Increasing the Rate of Wound Re-epithelization and Epidermal Growth Journal of Investigative Dermatology · 2008 · 19 citations
    19. Stem cell rejuvenation and the role of autophagy in age retardation by caloric restriction: An update Mechanisms of Ageing and Development · 2018 · 19 citations
    20. Hair Growth Promoting Effect of <i>Hottuynia cordata</i> Extract in Cultured Human Hair Follicle Dermal Papilla Cells Biological & Pharmaceutical Bulletin · 2019 · 16 citations
    21. Dexpanthenol Promotes Cell Growth by Preventing Cell Senescence and Apoptosis in Cultured Human Hair Follicle Cells Current Issues in Molecular Biology · 2021 · 13 citations
    22. Editorial: Stem cell exhaustion in aging Frontiers in Aging · 2024 · 13 citations
    23. The human promyelocytic leukemia protein is a tumor suppressor for murine skin carcinogenesis Molecular Carcinogenesis · 2008 · 10 citations
    24. Imbalanced redox dynamics induce fibroblast senescence leading to impaired stem cell pools and skin aging Free Radical Biology and Medicine · 2025 · 7 citations
    25. BMI1 is required for melanocyte stem cell maintenance and hair pigmentation Pigment Cell & Melanoma Research · 2023 · 4 citations
    26. Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1 Frontiers in Cell and Developmental Biology · 2020 · 3 citations
    27. Condylomata acuminata of HIV-positive men may harbour focal areas of dysplasia: relevant implications for the management of human papillomavirus-induced disease in high-risk patients British Journal of Dermatology · 2016 · 3 citations
    28. The accelerated aging skin in rhino‐like SHJH<sup><i>hr</i></sup> mice Experimental dermatology · 2022 · 1 citations
    29. Niacinamide Down-Regulates the Expression of DKK-1 and Protects Cells from Oxidative Stress in Cultured Human Dermal Papilla Cells Clinical, Cosmetic and Investigational Dermatology · 2021 · 1 citations
    30. Reconstructing protein conformations to activate follicular enzyme-nutrient reservoirs for reversing follicle aging Bioactive Materials · 2026