1265 citations
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October 2013 in “The Journal of Clinical Endocrinology and Metabolism” This guideline from the Endocrine Society recommends using the Rotterdam criteria for diagnosing polycystic ovary syndrome and outlines first-line treatments, emphasizing hormonal contraceptives and lifestyle intervention.
4 citations
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July 2024 in “Biomolecules” This review suggests systemic changes in polycystic ovary syndrome may increase the risk of neurodegeneration, potentially linking it to Alzheimer's disease through common pathways affecting tryptophan metabolism.
May 2023 in “Metabolites” In this study, adding α-lactalbumin to myo-inositol treatment improved ovulation rates, menstrual cycle duration, and hyperandrogenism in women with PCOS more effectively than myo-inositol alone, suggesting potential benefits for those resistant to inositol treatment.
11 citations
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January 2024 in “Gynecological Endocrinology” This narrative review on inositol use in PCOS treatment found positive results for myo-inositol alone and effective outcomes for a myo-inositol/D-chiro inositol combination at a 40:1 ratio, suggesting further research on other combinations like 66:1 to 100:1.
January 2025 in “Journal of Education Health and Sport” In this study, metformin was highlighted as effective in improving metabolic parameters and restoring ovulatory function in women with PCOS by enhancing insulin sensitivity, inhibiting hepatic gluconeogenesis, and influencing lipid metabolism, although a tailored, comprehensive treatment plan remains essential.
1 citations
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March 2023 in “Nutrients” This joint consensus statement from several Polish professional associations discusses strategies for improving obesity treatment and enhancing primary care's role in managing obesity, with no new empirical data reported.
1 citations
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January 2023 in “Metabolites” This review discusses the relationship between gut microbiota and polycystic ovarian syndrome (PCOS), including its potential mechanisms and the role of alterations in microbiome composition on PCOS pathophysiology.
September 2022 in “Women's healthcare” This review discusses various aspects of polycystic ovary syndrome, including its prevalence, diagnosis, and treatment options, and reports no new empirical results.
In this study, women with polycystic ovary syndrome showed higher scores in character strengths like hope and judgement compared to those without PCOS.
10 citations
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March 2016 in “The Journal of Obstetrics and Gynecology of India” This review proposes renaming polycystic ovarian syndrome to "Hyperandrogenic Persistent Ovulatory Dysfunction Syndrome" to better reflect its diagnostic criteria and promote consistency in research, but reports no new clinical findings.
21 citations
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December 2007 in “Primary Care” This article reviews the challenges in treating PCOS, noting the potential benefits of insulin sensitizers on ovulatory function and pregnancy outcomes, and calls for more long-term studies on metabolic interventions.
15 citations
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January 2015 in “Clinical and Experimental Reproductive Medicine” This study reports that obesity significantly influences cardiovascular and metabolic disturbances in women with PCOS, with overweight women experiencing more severe symptoms compared to their non-obese counterparts.
222 citations
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January 2014 in “International journal of reproductive medicine” This paper reviews the complex pathophysiology of polycystic ovary syndrome, exploring how hormonal and metabolic disturbances contribute to its symptoms and related health risks, but it presents no new findings.
53 citations
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September 2014 in “Reproductive Biology and Endocrinology” This study observed that among women with polycystic ovary syndrome, those with the most severe phenotype showed the highest levels of metabolic disturbances, indicating the need for metabolic screening in these cases.
28 citations
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August 2003 in “Steroids” This study found that untreated hirsute patients have lower expression of type 2 17β-HSD mRNA in scalp hairs, indicating potential disturbances in androgen metabolism, compared to treated hirsute patients.
September 2025 in “Australian Journal of Herbal and Naturopathic Medicine” This review reported that Withania somnifera (Ashwagandha) significantly improved symptoms like vasomotor disturbances, psychological well-being, and sleep quality in perimenopausal women and was well tolerated, with largely mild side effects in examined trials.
1 citations
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August 2024 in “Zanco Journal of Medical Sciences” This study observed that women with PCOS have lower resistive and pulsatility index values in ovarian stromal arteries compared to normal women, indicating Doppler ultrasonography as an effective diagnostic tool for PCOS-related hemodynamic changes.
June 2023 in “Journal of multidisciplinary sciences” This review examines the potential link between polycystic ovary syndrome and reproductive cancers, highlighting possible underlying causes as well as the ongoing debate over the cancer risk in these patients.
883 citations
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August 2016 in “Nature Reviews Disease Primers” This review discusses the current understanding of polycystic ovary syndrome, focusing on its epidemiology, pathophysiology, diagnosis, management, and future research directions, but reports no new clinical results.
131 citations
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August 2004 in “Best Practice & Research in Clinical Obstetrics & Gynaecology” This article reviews the complex pathophysiology of polycystic ovary syndrome, highlighting how genetic, hormonal, and environmental factors contribute to its diverse symptoms, and reports no new results.
30 citations
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January 2015 in “BioMed Research International” Continuous light exposure in rats leads to PCOS-like symptoms and suggests sleep habits might affect the disorder's development.
18 citations
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July 2019 in “Clinical Endocrinology” The researchers reported that among Mediterranean Sicilian women with PCOS, Phenotype B exhibited the most severe metabolic abnormalities, notably obesity and altered glucose metabolism, whereas Phenotype D showed no such issues.
7 citations
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April 2015 in “General and Comparative Endocrinology” Finasteride negatively affects fish reproduction and gonadal development.
3 citations
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January 1992 in “Gynecological Endocrinology” This study concluded that serum Adiol-G levels generally parallel testosterone levels and, therefore, do not effectively serve as a marker of peripheral androgen excess in women with androgenic symptoms.
January 2025 in “International Journal of Gynaecology Research” This study found that serum cystatin C levels may be elevated in adolescent females with PCOS, suggesting it could serve as a predictive marker for metabolic and cardiovascular issues independent of renal function.
June 2024 in “Clinical Endocrinology and Metabolism” This article examines when it is appropriate to prescribe estrogen for women with hormonal imbalances, utilizing decades of clinical practice, expert consultation, and a comprehensive literature review.
December 2023 in “Anti-Aging Eastern Europe” This review discusses the interplay between polycystic ovary syndrome, aging, and fertility in women, and reports no new clinical results; the authors highlight pathways and interventions needing further research.
November 2018 in “International Journal of Current Pharmaceutical Research” This review discusses the causes, underlying mechanisms, diagnosis, and treatment strategies for polycystic ovary syndrome but reports no new clinical findings.
March 1997 in “Journal of Endocrinology/Journal of endocrinology” Excessive hair growth in women can be treated with medications like spironolactone and finasteride, and male-pattern baldness in women can be improved with similar treatments.
4 citations
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October 2024 in “Cureus” This review discusses the association between polycystic ovarian syndrome and hypertension, highlighting evidence of metabolic factors influencing this potential link and stressing the need for further research in this area.