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Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

The document recommends using both clinical evaluation and various measurement methods to assess skin greasiness, considering factors like temperature and hormones.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Fat cells in the skin help start healing and form important repair cells after injury.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.

Lower SHBG levels may increase the risk of PCOS.

Targeted cancer therapies often cause skin reactions, so dermatologists must manage these effects.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

Six new genetic regions linked to early hair loss also connect to Parkinson's disease and prostate cancer, possibly leading to new treatments.

Activin helps skin growth and healing mainly through stromal cells and affects keratinocytes based on its amount.

Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.

Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.

Male hormones are important for hair and oil gland development and can cause conditions like excessive hair growth and acne.

Some heart drugs show promise for other conditions, but more research is needed to confirm their effectiveness and safety.

Tissue-resident memory T cells can protect against infections and cancer but may also contribute to autoimmune diseases.

The conclusion is that published guidelines are improving transgender medical care, but more research and education in transgender medicine are needed.

Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

Researchers found 63 genes linked to male-pattern baldness, which could help in understanding its biology and developing new treatments.

Fadrozole and finasteride change gene expression related to sex hormones and thyroid hormones in frog larvae development.

Spironolactone can reduce hair growth in women with hirsutism.

Obese women with PCOS show a male-like pattern in certain fat tissue gene expressions.

Tcf3 helps cells move and heal wounds by controlling lipocalin 2.

The study found that certain microRNAs are higher in the cells and lower in the fluid of women with a specific type of polycystic ovary syndrome, and one microRNA could potentially help diagnose the condition.

Androgen conjugates might be better indicators of skin sensitivity to hormones in women with excessive hair growth.

Cancer treatments often cause hair disorders, significantly affecting patients' quality of life, and better management methods are needed.