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Nanoparticulate systems improve drug delivery by controlling release, protecting drugs, changing absorption and distribution, and concentrating drugs in targeted areas.

The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.

The research suggests that the global distribution of PCOS is likely due to historical human migration and that genes affecting PCOS may have different impacts on males and females.

The document concludes that more research is needed to understand excessive hair growth in women with normal hormone levels and regular ovulation.

Melatonin improves cashmere goat hair growth and quality by increasing antioxidants and reducing cell death.

Hormonal treatments are effective for severe or persistent acne and should be used with other acne therapies, considering potential side effects.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Hair loss treatments work better with lifestyle changes.

Testosterone therapy is generally safe for transmen, improves sexual function, and has manageable health risks with proper monitoring.

The conclusion is that androgen receptor gene polymorphism might be a marker for polycystic ovary syndrome, but more research is needed.

Obese women with PCOS are more likely to have fatty liver disease.

Gonadal dysgenesis, like Turner's and Klinefelter's syndromes, negatively affects bone health, but hormone treatments can help.

The enzyme 17β-HSD type 2 mainly performs oxidation in human sebaceous glands, which may help protect against acne.

Women with PCOS have lower ghrelin levels and a weaker response to sugar, which might affect their feeling of fullness and lead to overeating.

Women with PCOS are more likely to have insulin resistance and obesity, especially those with the most severe type I PCOS.

Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.

Excessive hair growth can be assessed by history, exam, and blood tests, and treated with medication like dexamethasone, birth control pills, and spironolactone.

Beard and scalp hair cells have different gene expressions, which may affect beard growth characteristics.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

Metformin and rosiglitazone both improved insulin use and hormonal symptoms in women with PCOS.

Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.

Certain genetic variations in the SHBG gene are linked to an increased or decreased risk of PCOS in Mediterranean women.

Melatonin solution helps treat hair loss in men and women.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Certain hormone treatments can improve acne and related conditions in women.

Natural molecules like inositols, resveratrol, vitamins, and omega-3 fatty acids may help manage Polycystic Ovary Syndrome (PCOS), but their effects vary and need more exploration.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Prostaglandin E2 affects human platelet activity in complex ways that could lead to personalized heart disease treatments.

Metformin taken during pregnancy increases SHBG in newborns but doesn't change other hormone levels in mothers or babies.

Androgens may influence T cells, contributing to higher autoimmune liver disease risk in women.