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B2m-free HLA variants may be a new class of HLA important in immune responses and diseases.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Sex hormones affect reproduction, sexual development, and oral health, and it's important for dental practitioners to understand their effects and interactions.

Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.

The document concludes that systemic therapy is becoming more important in treating head and neck cancer, with new treatments showing promise.

Anticancer drugs like methotrexate and trimetrexate could be effective and safe for treating malaria at low doses.

A woman with dermatomyositis showed rare skin symptoms, was treated successfully, and her case suggests checking for cancer in similar patients.

A woman with a rare type of dermatomyositis improved with low-dose prednisone and methotrexate.

Effective PCOS treatments require targeting specific signaling pathways.

The study concluded that both anti-Mullerian hormone and LH/FSH ratio are higher in women with PCOS and combining these markers with BMI could improve diagnosis accuracy.

The article concludes that global standardization in PCOS research is crucial for accurate diagnosis and understanding of the condition.

Hormone therapy for breast cancer often leads to sexual issues like vaginal dryness and decreased libido.

Iron deficiency may contribute to hair loss.

Most women with PCOS have high levels of male hormones, and free testosterone is the best marker for this.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

Skin problems can be signs of hormone-related disorders and recognizing them early is important for treatment.

Most adrenal cortex tumors are benign and non-secreting, but proper diagnosis and treatment are important due to the rare possibility of cancer.

Skin reactions from cancer treatments might predict how well the treatments work.

Men taking 5-alpha-reductase inhibitors before or after bladder cancer diagnosis had a lower risk of dying from the disease.

Menstrual disorders are common in adolescents and can be influenced by weight, activity, and health issues, requiring careful evaluation and more research for effective treatment.

The French Endocrine Society suggests diagnosing PCOS with two of three signs, recommends lifestyle changes and clomiphene for treatment, and calls for more research on certain treatments and tests.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Testosterone replacement can help women with low libido and mood, but they need to have enough estrogen first to avoid side effects.

New cancer treatments aim to reduce side effects and improve effectiveness.

Skin changes can help diagnose and manage endocrine disorders like thyroid problems, diabetes, and adrenal gland conditions.

The bulletin provides guidelines for diagnosing and managing PCOS, suggesting weight loss, hormonal contraceptives, and diabetes screening, with clomiphene for infertility and various treatments for excess hair.

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

A boy with a rare form of early puberty caused by a new gene mutation responded well to treatment aimed at reducing testosterone and preserving adult height.

C/EBPalpha and C/EBPbeta are crucial for normal skin and oil gland cell development in adult mice.

Gene mutations can cause problems in male genital development.