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Nanoparticulate systems improve drug delivery by controlling release, protecting drugs, changing absorption and distribution, and concentrating drugs in targeted areas.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Dendrobium officinale polysaccharides may help with hair growth, skin moisturization, and protection against oxidative damage.

Hidradenitis suppurativa may be related to hormones and patients often have metabolic disorders; more research is needed to understand this connection.

Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.

RADA16 is a promising material for tissue repair and regenerative medicine but needs improvement in strength and cost.

Hair problems are common and distressing for women, but increasing knowledge of treatments offers hope.

Young women with PCOS have a higher risk of high blood pressure and metabolic syndrome, but these risks may decrease after age 40.

Nanomaterials in biomedicine can improve treatments but may have risks like toxicity, needing more safety research.

Certain skin conditions can indicate insulin resistance and should prompt lifestyle changes and medical treatment to manage underlying health issues.

The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

Hair loss in cancer patients can be related to the cancer itself, treatment, or other conditions, and understanding it is important for diagnosis and patient care.

AIRE-deficient rats developed severe autoimmune disease similar to APECED, useful for testing treatments.

Hormonal changes after childbirth and menopause can lead to women's hair loss and facial hair growth, with a need for better treatments.

Spironolactone harms fish reproduction and is more potent in fish than invertebrates, needing environmental monitoring.

Some growth factors, while important for normal body functions, can cause diseases when not regulated properly.

Betacoronaviruses, like COVID-19, may cause hormone system dysfunction and affect disease susceptibility and severity.

Sex hormones affect hair and feather growth and may help manage alopecia and hormone-dependent cancers.

Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.

Stress can worsen skin conditions and affect mental health, so doctors should include stress management in skin treatment.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

Quick treatment of hair disorders in teenage girls is important because of the emotional effects.

New chemotherapy drugs cause skin side effects, but treatments like minocycline and tetracycline can help reduce them.

Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

The article concludes that correctly diagnosing systemic causes of hair loss requires a detailed clinical evaluation and a systematic diagnostic approach.

Genetic counselors should be culturally skilled and aware of transgender patients' unique health risks and needs.

Canine epidermal neural crest stem cells could be a promising treatment for spinal cord injuries in dogs.