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The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

Shorter CAG repeats in a specific gene may increase male hormone activity and symptoms like acne and excess hair in women with PCOS.

The document concludes that treating PCOS requires a combination of drugs to manage reproductive and metabolic symptoms, with more research needed on combination therapies.

The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.

Women with PCOS are more likely to have fatty liver disease and worse metabolic health.

Hormone treatments can help with women's skin and hair disorders, but they need careful monitoring and more research.

Menstrual disorders are common in adolescents and can be influenced by weight, activity, and health issues, requiring careful evaluation and more research for effective treatment.

Metformin improves menstrual cycles and hormone levels in women with PCOS, mostly within the first 6 months.

Finasteride reduces hair growth and is safe for women with excessive hair.

Insulin-sensitizing drugs like metformin can help with ovulation, weight loss, and lower testosterone in some women with PCOS.

New treatments for PCOS focus on insulin resistance and reducing testosterone levels, along with traditional hormone therapies.

People who carry the 21-Hydroxylase Deficiency gene are not more likely to have excessive male hormone levels.

The study concluded that both anti-Mullerian hormone and LH/FSH ratio are higher in women with PCOS and combining these markers with BMI could improve diagnosis accuracy.

Acanthosis nigricans is a skin condition that may indicate a higher risk for insulin resistance and type 2 diabetes, and more research is needed to understand and treat it.

Men with common hair loss may have a higher risk of heart disease and diabetes, and should be checked for these conditions.

The document concludes that managing hirsutism involves identifying the cause, using a scoring system for severity, combining cosmetic and medical treatments, encouraging weight loss, and providing psychological support, while noting the need for more research on drug treatments.

Women with excessive male-pattern hair growth should get a full hormone check-up to find and treat any underlying issues, considering both medical and emotional aspects.

Many women with PCOS have undiagnosed health issues and show different symptoms based on the clinic they visit.

Eating isoflavone can help mice grow hair by increasing a growth factor.

Insulin resistance in women with PCOS can lead to serious health issues, but lifestyle changes and certain medications can help manage symptoms.

Blocking the androgen receptor in skin cells reduces their growth response to male hormones, suggesting a possible treatment for skin conditions linked to androgens.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.

The VEGF +405G allele may increase the risk of PCOS in South Indian women.

Testosterone therapy can improve sexual desire and function in postmenopausal women but should be used cautiously and not based solely on testosterone levels.

Hirsute women have lower type 2 17β-HSD enzyme levels, which improve with treatment.

New compounds may soon be tested to treat excessive hair growth in women.

The document concludes that proper diagnosis and combined treatments are key for hirsutism management, and weight loss may help overweight patients.

Birth control pills combined with bicalutamide are more effective at reducing excessive hair growth in women with PCOS than birth control pills alone.

PCOS may start before birth, involves metabolic issues, and can be treated with drugs like metformin and lifestyle changes.

The study found that women with hyperandrogenic PCOS have higher levels of AKT1 and AKT2 proteins in their cells, which may lead to cell dysfunction.