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Adult female acne requires a comprehensive treatment approach, including medical options and lifestyle changes, with attention to psychological well-being.

Some women with PCOS have CYP21 mutations and IRS1 variants, but these genetic factors are not major contributors to PCOS.

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

The document concludes that treating PCOS requires a combination of drugs to manage reproductive and metabolic symptoms, with more research needed on combination therapies.

The review found no clear link between vitamin D receptor gene variations and polycystic ovary syndrome.

Metformin should be used for PCOS mainly in those with glucose intolerance, and has limited benefits for infertility or hirsutism.

Severe insulin resistance can be managed with medication, lifestyle changes, and treatment for related conditions.

LPA3 is crucial for embryo implantation and links LPA to prostaglandin signaling.

Young women with PCOS have a higher risk of high blood pressure and metabolic syndrome, but these risks may decrease after age 40.

Continuous light exposure in rats leads to PCOS-like symptoms and suggests sleep habits might affect the disorder's development.

Certain genetic variations are linked to increased androgen levels in PCOS, but more research is needed to understand these connections fully.

The VEGF +405G allele may increase the risk of PCOS in South Indian women.

The document concludes that proper diagnosis and combined treatments are key for hirsutism management, and weight loss may help overweight patients.

The combination therapy improved PCOS symptoms in both obese and non-obese women, with weight loss in the obese group.

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.

The PCOS-specific questionnaire needs more work to fully measure quality of life in clinical trials.

Different anti-androgen medications can help treat excessive hair growth, but the right choice depends on accurate diagnosis.

Finasteride improves hair growth and reduces hirsutism in women, but side effects and optimal dosages need further research.

Spironolactone did not make hair thinner in women with excess hair growth.

An mFG score of 7 or higher indicates hirsutism in Filipino women, often linked to higher free testosterone levels.

Women with PCOS have more emotional and body image issues than healthy women.

The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.

Cross-sex hormone therapy is important for managing gender dysphoria and requires careful monitoring and healthcare provider education.

Men taking 5-alpha-reductase inhibitors before or after bladder cancer diagnosis had a lower risk of dying from the disease.

High levels of male hormones are very common in women with PCOS and affect their metabolism differently depending on their weight.

Isotretinoin improves severe acne without changing androgen or insulin levels but may increase body weight and triglycerides.

Adrenal gland disease is common in ferrets and causes hair loss and other symptoms.

Androgen excess disorders in women were effectively treated with spironolactone, estrogen, and dexamethasone.

Treating hirsutism in women often requires a mix of medications and cosmetic methods for best results.

Women with PCOS in North China often have hirsutism and acne, with hirsutism linked to metabolic issues.