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This study suggests that nerve growth factor may support hair follicle growth in Liaoning cashmere goats through pathways involving its receptor, TrkA, particularly during the anagen phase.

This study found that human outer root sheath cells express VEGF receptor-2, and exogenous VEGF165 significantly stimulates their proliferation through activation of the ERK signaling pathway.

This study found that extracellular vesicles from low-passage dermal papilla cells may activate hair growth by delivering miR-140-5p, which downregulates BMP2 signaling, suggesting potential therapeutic targets for alopecia.

TP0427736 may help treat hair loss by blocking a specific protein and promoting hair growth.

This study found that applying HHORSC exosomes may enhance the hair inductivity of dermal papilla cells, potentially improving treatments for hair loss.

In this study, collagen I decellularized scaffolds enhanced the growth and melanotic properties of hair follicle melanocytes, suggesting their potential as effective carriers for transplantation in vitiligo treatment.

In this study, researchers reported that adenosine stimulated hair shaft elongation in cultured human hair follicles by promoting proliferation and prolonging the anagen phase, suggesting the A2B adenosine receptor in outer root sheath keratinocytes as a promising target for treating hair growth disorders like alopecia.

This study found that anisotropic osmolyte solutions may improve hair follicle turnover and condition in both in vitro and in silico models, as well as in human volunteers with hair disorders.

This review discusses the cell biological characteristics of the outer root sheath of normal human hair follicles and highlights some similarities and differences with trichilemmal tumors, but reports no new results.

The researchers reported that the antipsoriatic compounds 1,25-dihydroxy-vitamin D3 and calcipotriol thinned the living cell compartment in organotypic ORS cultures by accelerating the differentiation pathway rather than affecting proliferation.

This study found that nestin-negative hair follicle stem cells can differentiate into neural stem cell-like cells, but not mature neurons, through a multi-step neuro-induction process.

In this study, the researchers optimized a method for culturing melanocyte precursors from hair follicles and found that 1,25-dihydroxyvitamin D3 significantly promotes their differentiation and melanin synthesis.

This study reports that the side population technique can isolate melanocyte stem cells from human hair follicles, potentially allowing them to be used for skin pigmentation repopulation.

This study found that cultured outer root sheath cells from human hair follicles expressed a keratin profile similar to their in vivo environment, indicating environmental influence on keratin expression.

This study describes a new tissue culture method that successfully induces outer root sheath cells from hair follicles to differentiate into a multilayered epithelium with characteristics similar to normal interfollicular epidermis.

Overexpression of certain genes can shorten hair by disrupting the hair-growth cycle.

This laboratory study found that collagen matrices with high-sulfated hyaluronan may enhance the cultivation of human keratinocytes and melanocytes from hair follicles for epidermal graft development.

This study developed a new melanocyte cultivation medium without chemical mitogens, melanogenesis enhancers, or bovine products, demonstrating successful proliferation and melanotic differentiation of human melanocytes from hair follicles.

Testosterone, DHT, and estradiol significantly affect hair cell growth.

This study observed that activating the Wnt/β-catenin pathway enhances hair follicle stem cell proliferation and differentiation, promoting hair growth and wound healing, and demonstrated the potential for outer root sheath transplants to aid skin repair, although challenges remain for clinical application.

This study found that human hematopoietic mesenchymal stem cells increased the viability and migration of human outer root sheath cells in an in vitro alopecia areata model, involving Wnt/β-catenin and JAK/STAT pathways.

In this study, researchers demonstrated that human hair follicle outer root sheath cells release ATP, serotonin, and histamine in response to mechanical stimulation, which subsequently activates surrounding sensory neurons.

This study demonstrated that autologous mesenchymal stem cells from hair follicles, when combined with a novel gelatin-based hydrogel, showed promising osteogenic potential and could offer a non-invasive alternative for bone regeneration.

This study found that mesenchymal stem cells sourced from hair follicle outer root sheath showed higher differentiation efficiency and angiogenic potential for vascular graft applications compared to adipose-derived stem cells.

Minoxidil enhances hair growth and preserves the root sheath in cultured follicles.

This study found that stress hormones, particularly CRF, can inhibit hair growth and induce hair loss by affecting human dermal papilla cells and hair follicles, suggesting a functional HPA axis in these cells.

This study in Hexi cashmere goats found that secondary follicle activity increases with time, and Hoxc13 expression varies significantly across different growth stages, suggesting a role in follicle activity.