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This review discusses recent advancements in generating appendage-bearing skin organoids from pluripotent stem cells and their potential applications in dermatological research, but reports no new clinical results.

This study developed protocols to create skin organoids with hair follicles and other appendages from human induced pluripotent stem cells, representing a significant step towards understanding hair follicle development and potential applications in modeling skin diseases and reconstructive surgeries.

In this study, researchers successfully derived skin organoids from mouse pluripotent stem cells that spontaneously produce hair follicles, potentially aiding in hair growth research and in vitro drug testing.

This study demonstrates that using transwell culture significantly influences hair follicle formation in skin models, potentially improving dermatology and skin research methodologies.

In this study, iPSC-derived epidermal organoids demonstrated potential as a novel tool for regenerative medicine by producing high-performance extracellular vesicles that promote proliferation, migration, and angiogenesis in cell-free therapies for wound healing.

This review highlights that skin organoids, advanced three-dimensional models mimicking human skin, are emerging as effective alternatives to traditional culture models and human skin, overcoming limitations of two-dimensional systems and ethical concerns, and are being increasingly used in areas like developmental biology and disease modeling.

This study developed a new human in vitro hair model that replicates in vivo hair characteristics and may be suitable for high throughput screening of hair growth treatments.

This study demonstrated that a mechanical-chemical cascade involving dermal cell contraction and the activation of Piezo1 in epidermal cells is crucial for initiating interactions necessary for hair follicle regeneration in skin organoids.

This review summarizes the latest progress and challenges in skin organoid research, emphasizing advancements in organoid construction, applications in disease modeling, and factors affecting tissue maturation, while noting barriers such as vascularization and neural integration that hinder clinical translation.

This study developed an in vitro system to analyze human skin progenitor cells' ability to form hair peg-like structures, providing insights for engineering hair follicle organoids.

In this review, researchers summarize key factors in constructing skin organoids, including cell source and assembly methods, and emphasize advances such as air-liquid interface culture for improving tissue development, aiming to guide standardized protocols and future clinical applications.

This review discusses recent advancements in regenerative medicine, including functional organ regeneration and the creation of mini-organs, and reports no new clinical results.

This study mapped the development of the human pilosebaceous unit in prenatal scalp skin using multi-modal analysis, finding that epithelial-mesenchymal interactions guide cellular fate and validated tissue-patterning through a hair-bearing skin organoid model.

This study demonstrated that novel cryomicroneedles loaded with hair follicle organoids (cryoMN@HFOs) can effectively deliver and develop into functional hair follicles after intradermal transplantation in animal experiments, suggesting promising potential for human hair follicle reconstruction.

This review highlights the complex interplay between intrinsic and extrinsic factors influencing skin aging, emphasizing the need for advanced human-specific models to study aging mechanisms and develop new therapies.

This study describes a protocol for generating hair follicle germ-like organoids from human skin cells, which may aid in alopecia drug discovery and understanding hair follicle regeneration.

This study constructed a comprehensive atlas of prenatal human skin, revealing that innate immune cells, such as macrophages, play a crucial role in skin morphogenesis by interacting with non-immune cells, influencing hair follicle formation and angiogenesis beyond their traditional immune functions.

This mini-review reports that advances in microbioreactor technology, particularly with microfluidics, significantly enhance eukaryotic cell-based biomedicine by improving productivity, scalability, and reproducibility in applications like CAR T-cell manufacturing and organoid growth, though challenges in scalability and material selection remain.

This review discusses the development of hair-on-a-chip technology for hair follicle research and alopecia treatment, reporting no new clinical results but highlighting future research directions.

In this study by Sawada et al., the researchers developed a human striatal model using stem cells and postmortem samples, revealing accelerated neuronal maturation and specific gene expression changes linked to schizophrenia risk, which may inform future research on the disorder's developmental roots.

This review discusses the development and potential applications of organoids for human disease modeling and regenerative medicine but reports no new experimental results.

This literature review discusses the challenges and potential strategies for creating fully functional hair follicles capable of active cycling, emphasizing the molecular mechanisms, signaling pathways, and innovative regenerative techniques, such as hair micropatterning and three-dimensional printing, crucial for optimizing hair follicle regeneration.

This review highlights how organoid technology is transforming precision medicine by summarizing its development and applications in modeling diseases, testing drug efficacy, and tailoring patient-specific treatments, despite current challenges in standardization and ethical considerations.

This review discusses the promise of human organoid technology as an alternative to animal models in drug development, highlighting its growing research and commercial potential.

This review highlights recent advances in CRISPR-based lineage tracing methods that can improve our understanding of skin stem cell behavior, regeneration, and disease, with potential applications in organoids and model organisms.

This review highlights the complexities of hair graying and the limitations of current models to fully replicate hair follicle pigmentary unit function, suggesting that technologies like organoids and bioprinting show promise but require further development for effective hair repigmentation interventions.

This article reviews the role of stem cells in tissue development, tumor formation, and organoid generation, and highlights the potential of epigenetic regulation in advancing regenerative medicine and cancer treatment, without presenting new experimental results.

This study demonstrated that skin organoids derived from human stem cells can model cutaneous tuberculosis, revealing that fibrosis development in Mycobacterium tuberculosis-infected organoids is linked to the PI3K-AKT and AP1 pathways in fibroblasts, and suggesting the potential for antifibrotic treatment evaluation.

This study established a 3D in vitro culture system of canine keratinocyte organoids to study epidermal function and address skin disorders in dogs, though additional growth factors are needed for hair follicle development.

In this study, researchers engineered ventral skin organoids (vSkOs) with specific cellular compositions and signaling environments to generate human amnion-like tissues called Amnioids, offering new tools for studying human development and potential regenerative therapies.