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The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

5-alpha reductase inhibitors, like finasteride and dutasteride, may cause depression, but more research is needed to understand why.

Testosterone increases acidification in the vas deferens by up-regulating V-ATPase.

Hormone therapy in transgender individuals can increase acne and affect hair growth and loss.

Some people experience lasting sexual, psychological, and sleep problems after using finasteride or SSRI antidepressants, possibly due to similar underlying causes.

The document concludes that inflammation markers can be used in diabetes, vitamin D3 affects immune pathways, hyperthyroidism changes hormone levels, androgen levels help diagnose Adrenocortical Carcinoma, erectile dysfunction is linked to diabetes, hypogonadism is common in HIV-infected males, and hormones can be biomarkers for various conditions.

Finasteride in male rats causes liver and metabolic issues in their offspring.

The document concludes that non-binary individuals need compassionate support and recognition in healthcare, without being pathologized.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

New male hormonal contraceptives show promise but need more research on long-term effects and funding for larger trials.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Normal levels of DHT can reduce belly fat and increase muscle, but too much can lead to hair loss, prostate issues, and possibly heart disease.

MENT could be a better option than testosterone for male hormone therapy and birth control because it works well at lower doses and has fewer side effects on the prostate.

Thyroid hormones and androgens affect gene expression in frog reproductive organs differently between males and females.

Finasteride reduces melanin production, possibly treating hyperpigmentation and melanoma, but needs more safety research.

Testosterone and dihydrotestosterone have similar effects on body composition and metabolic health in men.

Phthirusa pyrifolia extract may lower testosterone and harm male rat reproduction without damaging the liver or kidneys.

Finasteride lowers good cholesterol, raises bad fats, and may increase heart disease risk.

Pueraria mirifica extract may help treat benign prostatic hyperplasia.

Gender identity can be more diverse than just male or female.

Testosterone helps prevent skin damage in males by acting through both estrogen and androgen pathways.

Testosterone replacement therapy helps manage deficiency and has various methods, but requires careful monitoring to avoid side effects.

SARMs may be an effective treatment for a certain type of breast cancer by blocking cancer growth and spread.

Finasteride reduces blood vessel formation in seminal vesicles.