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This study suggests that TRPV3 may play a key role in dry skin-related itch, indicating potential for TRPV3 antagonists in treating pruritus resistant to histamine H1R antagonists.

This review discusses the therapeutic potential of Smoothened modulators for cancer treatment and explores their pharmacological implications, but reports no new clinical findings.

This review highlights potential negative impacts of certain medications on male fertility, such as hormonal disruption and germ cell toxicity, emphasizing the importance of clinicians being aware of these effects to advise on safer alternatives.

This study evaluated novel steroids' potential as future hormonal therapies for neuroprotection in glucose disorders, but emphasized that further research is needed to optimize androgen antagonist use in the context of COVID-19 progression.

This review discusses the genetic causes and pathogenesis of Olmsted syndrome, emphasizing the potential for a genotype-phenotype correlation due to TRPV3 mutations, and explores avenues for individualized treatment developments for this condition.

This study found that human epidermal keratinocytes express a functional μ-opiate receptor at both the mRNA and protein levels, potentially playing a role in skin physiology and pathology.

This article reviews the role of factor Xa inhibitors like Rivaroxaban and suggests they may eventually replace vitamin K antagonists, but their side effects require further clarification.

The researchers found that inhibiting soluble epoxide hydrolase, either genetically or pharmacologically, delayed the onset of chemically induced seizures related to GABA antagonism in experimental models.

Finasteride boosts morphine's pain relief, stops tolerance, and reduces withdrawal in rats.

This study found that 10,11-dibrominecrebanine (2Br-Cre) and Stephanine demonstrate significant anti-inflammatory and analgesic properties in various experimental models, with 2Br-Cre showing enhanced efficacy over Cre and both compounds potentially mediating their analgesic effects through opioid receptors.

This review discusses the potential therapeutic effects of targeting the endocannabinoid system for chemotherapy-induced peripheral neuropathy and reports no new clinical results, highlighting the need for ongoing research.

This study found that Asiasari radix extract may reduce hyperalgesia in mice by modulating NMDA and GABAA receptor activities without affecting cyclooxygenase activity.

This review highlights the importance of promptly addressing symptoms in patients with inflammatory bowel disease, whether they stem from disease activity, medication side effects, or related autoimmune conditions, but it reports no new findings.

This symposium discussed recent advances in understanding skin as a sensory organ, emphasizing the interactions between itch, pain, and touch pathways and highlighting potential therapeutic targets.

This study explores the use of low-dose naltrexone as a novel treatment for lichen planopilaris, but specific results or outcomes are not detailed in the abstract.

This review suggests that topically applied peptides may offer a promising alternative for managing pain in chronic wounds, with additional potential benefits of anti-inflammatory and regenerative activities, but acknowledges the challenges of delivering these peptides across damaged skin barriers.

This study found that finasteride reduced impulsivity in a rat model of pramipexole-induced probability discounting, possibly by normalizing D3 receptor expression in the nucleus accumbens.

This article reviews the challenges and treatment options for pancreatic cancer, emphasizing the need for a collaborative care approach due to the disease's advanced presentation and poor prognosis; it reports no new clinical findings.

This review discusses the neurobiology of sexual function and reports no new results; the authors cover multiple endocrine and neurotransmitter influences on sexual desire, arousal, and orgasm stages.

The skin acts like an endocrine organ, making hormones that affect skin diseases and respond to stress.

This study found a statistically significant increase in glycosylated hemoglobins among patients with adult-acquired panhypopituitarism undergoing long-term GH replacement therapy, with two developing diabetes requiring treatment.

In this study, low-dose naltrexone significantly reduced erythema in patients with frontal fibrosing alopecia and lichen planopilaris after one year, but no significant improvements were seen in other symptoms.

This review details the expression and diverse functions of melatonin receptors in non-neural tissues and reports no new clinical findings, emphasizing their potential as therapeutic targets across various physiological and pathological processes.

This article discusses the role of human hair follicles in neuroendocrinology and suggests potential new therapeutic targets by examining how neuromediators influence hair growth, pigmentation, and stem cell biology in organ cultures.

Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.

This review explores potential indications for prolactin receptor inhibitors beyond breast and prostate cancers, emphasizing the need for potent antibodies to further research prolactin receptor expression.

This study identified new potential targets and indications for several marketed drugs using in silico profiling, suggesting opportunities for drug repositioning.

This article reviews the possible therapeutic activities of Angelica gigas Nakai root extracts and their components, noting their potential effects on neuro-cognitive, metabolic, and other health conditions, and reports no new clinical results.

This study reviewed 16 notable drug repurposing patent applications from 2025, highlighting potential new uses such as guanfacine for autonomic dysfunction and disulfiram for subarachnoid hemorrhage survival, though many disclosures lack peer-reviewed studies and no patents are granted.

This study found that normal murine hair follicles are direct targets for melatonin bioregulation, expressing receptors that are regulated in a hair cycle-dependent manner, influencing keratinocyte apoptosis.