August 2025 in “Cosmetics” This review discusses the possible link between cosmeceuticals and frontal fibrosing alopecia but reports no conclusive findings; the authors stress further research on environmental triggers is needed.
In this retrospective study, researchers at a Spanish hospital found that the severity of frontal fibrosing alopecia, primarily affecting postmenopausal women, was correlated with the duration of the disease, though inflammatory signs were not linked with its progression.
February 2024 in “The Open dermatology journal” This systematic review reported that alopecia areata significantly impacts quality of life due to its psychological burdens, such as anxiety and depression, while emphasizing the need for increased awareness and support for affected individuals.
57 citations
,
August 2023 in “American Journal of Clinical Dermatology” JAK inhibitors and platelet-rich plasma show promise for treating alopecia areata.
45 citations
,
May 2024 in “International Journal of Molecular Sciences” This manuscript reviews the latest understanding of alopecia areata's pathogenesis, highlighting the roles of genetic, immunological, and environmental factors, with a focus on immune responses involving IFN-γ and cytotoxic CD8+ T-cells as key contributors to hair follicle inflammation and function disruption without follicle destruction.
40 citations
,
January 2022 in “Nutrients” This review explores the potential impact of nutrition on immune-mediated inflammatory skin diseases and evaluates whether dietary changes could help in treatment planning, but it presents no new clinical outcomes.
31 citations
,
July 2017 in “Stem cell investigation” This article discusses the use of platelet-rich plasma as a supportive treatment for hair loss, emphasizing its potential to enhance hair follicle health and patient satisfaction, but reports no new clinical results.
29 citations
,
December 2022 in “Dermatology and Therapy” This study reported that patients with alopecia areata experienced significant increases in work productivity loss and activity impairment due to worsening emotional symptoms, highlighting a need for better treatments.
23 citations
,
October 2024 in “British Journal of Dermatology” In this study, ritlecitinib showed sustained effectiveness and a favorable safety profile in treating alopecia areata in patients aged 12 and older over 24 months, with improvements observed in hair and eyebrow regrowth and patient satisfaction.
14 citations
,
September 2021 in “Journal of Inflammation Research” This study suggests that female patients with alopecia areata, especially those with nail abnormalities and atopic diseases, may have higher rates of coexisting autoimmune diseases.
14 citations
,
July 2021 in “Bioscience Reports” In this study, activation of Tgr5 was found to improve alopecia areata and bone microstructure in mice by down-regulating the JAK1-STAT3 signaling pathway.
9 citations
,
January 2015 in “Annals of dermatology/Annals of Dermatology” This retrospective study concluded that alopecia areata in elderly patients showed mild severity and a favorable treatment response, with no link found between hair graying and the extent of hair loss.
8 citations
,
May 2025 in “British Journal of Dermatology” This study found that the psychosocial impact of AA is more strongly related to patients' illness perceptions and stigma than to the severity of the disease.
7 citations
,
February 2022 in “JAAD International” This review suggests that alopecia areata may occur as a dermatologic manifestation of COVID-19, often appearing 1 to 2 months after infection; further research is needed to clarify this association.
4 citations
,
October 2019 in “Acta Médica Costarricense” This study highlights that while platelet-rich plasma is showing promise across multiple medical fields like dentistry and sports medicine, a lack of standardized protocols and robust clinical trials limits its routine clinical application.
4 citations
,
November 2025 in “Nature Reviews Disease Primers” 3 citations
,
August 2025 in “British Journal of Dermatology” This study highlights the challenges adolescents with alopecia areata face, such as increased bullying and emotional difficulties, and suggests that collaborations among dermatologists, psychologists, and educators could help improve their quality of life by reducing stigma and supporting mental wellbeing.
3 citations
,
July 2022 in “Indian journal of dermatology, venereology, and leprology” This study found that patients with alopecia areata had higher levels of oxidative stress markers and lower antioxidant enzyme activity compared to healthy controls.
3 citations
,
August 2020 in “PubMed” This review discusses the potential efficacy and applications of platelet-rich plasma in dermatology, highlighting its use in various skin conditions but reporting no new clinical results; the authors call for standardization of preparation and treatment methods.
3 citations
,
June 2020 in “Cureus” This case study highlights a 36-year-old woman with alopecia areata who experienced near complete hair regrowth after intralesional triamcinolone acetonide; further investigation revealed a systemic lupus erythematosus diagnosis.
3 citations
,
August 2024 in “Frontiers in Endocrinology” This study offers genetic evidence supporting a causal relationship between thyroid dysfunction and alopecia areata, which may help in managing and treating AA patients.
2 citations
,
February 2025 in “Medicine” This study found that among individuals with hair loss-related conditions, there was a significant association between alopecia and anxiety disorders, with affected individuals experiencing anxiety more frequently.
2 citations
,
June 2021 in “Cosmoderma” This article reviews the use of platelet-rich plasma (PRP) in various dermatological conditions and reports no new clinical results; the authors emphasize its efficacy and call for continued careful use.
2 citations
,
January 2020 in “Skin appendage disorders” This study in Mexican patients with alopecia areata found that body hair involvement was linked to disease progression, while treatment adherence was associated with both remission and progression.
2 citations
,
September 2025 in “Microorganisms” In this review, the authors explore the complex interplay between COVID-19 and autoimmune skin diseases, finding that SARS-CoV-2 may trigger or worsen these conditions, with increased risks following infection and vaccination, particularly with mRNA vaccines.
1 citations
,
September 2025 in “JAAD reviews.” This review discusses the condition alopecia areata and summarizes its available treatments, mentioning three recently approved Janus kinase inhibitors, but reports no new clinical results.
1 citations
,
March 2025 in “Skin Appendage Disorders” Healthcare access for alopecia areata in the USA is unequal among ethnic groups.
1 citations
,
April 2024 in “Journal of Drug Delivery Science and Technology” This review examines the use of microneedles for treating alopecia areata, highlighting their ability to enhance drug delivery through the skin by bypassing the outer barrier and promoting hair growth with minimal invasiveness.
1 citations
,
January 2024 in “Dermatologic Therapy” This study found that combining excimer light at 308 nm with tacrolimus 0.1% was more effective in treating alopecia areata of the scalp compared to excimer light alone, as indicated by a greater reduction in the SALT score and better improvement in Treg function.
1 citations
,
December 2023 in “Life” This article discusses the potential role of telocytes in skin regeneration and the need to understand their interaction with platelet-rich plasma, reporting no new experimental results.