research Indian Hedgehog Controls Proliferation and Differentiation in Skin Tumorigenesis and Protects Against Malignant Progression
Indian Hedgehog helps control skin cell growth and protects against aggressive skin cancer.
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research Upregulation of Interfollicular Epidermal and Hair Infundibulum β-Catenin Expression in Gsdma3 Mutant Mice
Mice with a Gsdma3 gene mutation have thicker skin and longer hair follicle openings due to increased β-catenin levels.
research Cell Death in the Skin: Mechanisms and Implications
Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.
research Mechanical Forces in Skin Disorders
Skin problems can be caused or worsened by physical forces and pressure on the skin.
research Dermoscopy: Not Just for Dermatologists
Dermoscopy is useful for many health professionals, not just dermatologists, in improving skin condition diagnoses and reducing unnecessary biopsies.
research Supportive Oncodermatology: Addressing Dermatologic Adverse Events Associated with Oncologic Therapies
Cancer survivors often experience worse skin problems from treatment than expected, and working with dermatologists could help improve their condition.
research Epidermal Nevi
Epidermal nevi are skin cell clusters linked to various syndromes.
research Activation of Nrf2 in Keratinocytes Causes Chloracne-Like Skin Disease in Mice
Activating Nrf2 in skin cells causes skin disease similar to chloracne in mice.
research Regulation and Role of GLI1 in Cutaneous Squamous Cell Carcinoma Pathogenesis
GLI1 might protect against the start of skin cancer and is not linked to cancer severity.
research Molecular Pathology of Skin Adnexal Tumors
New markers and pathways have been found in skin tumors, helping better understand and diagnose them.
research Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity
Activating β-catenin in different skin stem cells causes various types of hair growth and skin tumors.
research Recent Advances on Skin-Resident Stem/Progenitor Cell Functions in Skin Regeneration, Aging, and Cancers and Novel Anti-Aging and Cancer Therapies
New treatments targeting skin stem cells show promise for skin repair, anti-aging, and cancer therapy.
research Role of Beta-Catenin Activation Levels and Fluctuations in Controlling Cell Fate
Proper control of β-catenin activity is crucial for development and preventing diseases like cancer.
research Ultraviolet Radiation in Wound Care: Sterilization and Stimulation
UV radiation can help sterilize wounds and promote healing but requires careful use to avoid damaging cells.
research Alisertib Is Active as Single Agent in Recurrent Atypical Teratoid Rhabdoid Tumors in Four Children
Alisertib was found to be an effective and tolerable treatment for children with recurrent brain tumors.
research B-RAF, Nevi and Melanoma: A Complex Relationship
Male hair loss is mainly due to thinner hair, not less hair.
research Highlights from the 68th Annual Meeting of the Society of Investigative Dermatology
The meeting discussed vitamin D3's role in fighting tuberculosis, potential treatments for skin conditions like psoriasis, and hair follicle regeneration as a possible solution for hair loss.
research Hair Diameter vs. Hair Density in Male Androgenetic Alopecia
Hair loss is due to thinner hairs, not less hairs; hair diameter indicates balding progression and treatment effectiveness.
research Expanding Phenotype of Hereditary Fibrosing Poikiloderma with Tendon Contractures, Myopathy, and Pulmonary Fibrosis Caused by FAM111B Mutations: Report of an Additional Family Raising the Question of Cancer Predisposition and a Short Review of Early-Onset Poikiloderma
The document suggests a possible link between FAM111B gene mutations and increased cancer risk, particularly pancreatic cancer.
research Hair Matters in Melanoma Biology
The document concludes that the immune-inhibitory environment of the hair follicle may prevent melanoma development.
research Hair Follicle Regeneration Suppresses Ras-Driven Oncogenic Growth
Hair follicle regeneration may slow tumor growth.
research Androgen Receptor Mutations and Polymorphisms in African American Prostate Cancer
African American men with prostate cancer have more androgen receptor mutations, which may lead to more aggressive cancer compared to Caucasian American men.
research The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed
The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.
research Compound Heterozygous Mutations in Forkhead Box N1 (FOXN1) Lead to Severe Immunodeficiency but Normal Hair and Nail Development in Patients
Mutations in the FOXN1 gene cause severe immune issues but don't affect hair and nails.
research Non-Canonical Dimerization of the Androgen Receptor and Other Nuclear Receptors: Implications for Human Disease
Mutations in certain receptors can cause diseases and offer new treatment options.
research Overexpression of Hepatoma-Derived Growth Factor in Melanocytes Does Not Lead to Oncogenic Transformation
Overexpression of HDGF in melanocytes does not cause cancer.
research Molecular Mechanisms of Viral Oncogenesis in Humans
Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.
research YAP And TAZ Are Essential For Basal And Squamous Cell Carcinoma Initiation
YAP and TAZ proteins are necessary for the development of two types of skin cancer.
research Roles of Tumor Suppressors in Regulating Tumor-Associated Inflammation
Tumor suppressors help control inflammation in cancer and restoring their function could lead to new treatments.
research RSPO1-Mutated Keratinocytes From Palmoplantar Keratoderma Display Impaired Differentiation and Invasiveness: Implications for Squamous Cell Carcinoma Susceptibility in Patients With 46XX Disorder of Sexual Development
RSPO1 mutations in certain patients lead to skin cells that don't develop properly and are more likely to become invasive, increasing the risk of skin cancer.