research Montagna Symposium 2014: Skin Aging - Molecular Mechanisms and Tissue Consequences
The symposium concluded that understanding the molecular mechanisms of skin aging could lead to better clinical practices and treatments.
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510-540 / 1000+ resultsresearch Keratin-6 Driven ODC Expression in Hair Follicle Keratinocytes Enhances Stemness and Tumorigenesis by Negatively Regulating Notch
The study explored the impact of ornithine decarboxylase (ODC) overexpression in hair follicle keratinocytes on stem cell behavior and tumorigenesis, particularly its interaction with Notch signaling. Using two mouse models, K6-ODC/SKH-1 and K14-ODC/SKH-1, it was found that ODC overexpression in K6-ODC/SKH-1 mice led to a significant increase in tumor development and invasiveness, with 15±2.5 tumors per mouse compared to 6.8±1.5 in K14-ODC/SKH-1 mice. This was linked to an expansion of the stem cell compartment and a down-regulation of Notch signaling, suggesting that ODC may enhance skin carcinogenesis by promoting stem-like cancer-initiating cells and contributing to invasive squamous cell carcinomas.
research Rosmarinus Officinalis and Skin: Antioxidant Activity and Possible Therapeutic Role in Cutaneous Diseases
Rosemary may help treat various skin conditions due to its antioxidant and anti-inflammatory properties.
research The Therapeutic Role of ADSC-EVs in Skin Regeneration
ADSC-derived extracellular vesicles show promise for skin and hair regeneration and wound healing.
research Oral Lichen Planus: A Chronic Systemic Disease with Immune-Mediated Pathogenesis
Oral lichen planus is a chronic disease causing mouth discomfort and sometimes needs immunosuppressive treatment.
research Consumption of Fish Oil High-Fat Diet Induces Murine Hair Loss via Epidermal Fatty Acid Binding Protein in Skin Macrophages
Eating a high-fat fish oil diet caused mice to lose hair due to a specific immune cell activity in the skin linked to a protein called E-FABP.
research Cosmeceutical Therapy: Addressing the Effects of UVR Photoaging on the Skin’s Circadian Rhythm
Natural skincare products may help reduce sun damage and support the skin's daily cycle.
research RSPO1-Mutated Keratinocytes From Palmoplantar Keratoderma Display Impaired Differentiation and Invasiveness: Implications for Squamous Cell Carcinoma Susceptibility in Patients With 46XX Disorder of Sexual Development
RSPO1 mutations in certain patients lead to skin cells that don't develop properly and are more likely to become invasive, increasing the risk of skin cancer.
research The Effect of Different Preoperative Depilation Methods on the Healing of Wounded Skin in Mice
Sodium sulfide slows wound healing, while electric shaving is the safest for preoperative hair removal.
research Therapeutic Use of Caffeine in Dermatology: A Literature Review
Caffeine may benefit skin and hair health but more research is needed to confirm its effectiveness in dermatology.
research Targeting the Undifferentiated State of Cancer
Less differentiated melanoma cells are more vulnerable to a type of cell death, which could improve cancer treatments.
research Expression of Signaling Components in Embryonic Eyelid Epithelium
Eyelid cells share signaling components but differ in pathway activity.
research Trace Element Zinc and Skin Disorders
Zinc is important for skin health, and supplements can help treat various skin and hair disorders, but more research is needed for conditions like psoriasis and vitiligo.
research Exosomes Based Advancements for Application in Medical Aesthetics
Exosomes show promise for improving wound healing, reducing aging signs, preventing hair loss, and lightening skin but require more research and better production methods.
research Zinc and Zinc Transporters in Dermatology
Zinc is crucial for skin health and treating various skin disorders.
research Cutaneous Lymphadenoma Is a Distinct Trichoblastoma-like Lymphoepithelial Tumor With Diffuse Androgen Receptor Immunoreactivity, Notch1 Ligand in Reed-Sternberg-like Cells, and Common EGFR Somatic Mutations
Cutaneous Lymphadenoma is a unique skin tumor with specific protein markers and common gene mutations that may cause continuous cell growth.
research Spatiotemporal Labeling of Melanocytes in Mice
The research showed how melanocytes develop, move, and respond to UV light, and their stem cells' role in hair color and skin cancer risk.
research A Kaleidoscope of Keratin Gene Expression and the Mosaic of Its Regulatory Mechanisms
Keratin protein production in cells is controlled by a complex system that changes with cell type, health, and conditions like injury or cancer.
research Obesity and Wound Healing: Focus on Mesenchymal Stem Cells
Obesity can worsen wound healing by negatively affecting the function of stem cells in fat tissue.
research Regulation of Stem Cell Fate by HSPGs: Implication in Hair Follicle Cycling
HSPGs help control stem cell behavior, affecting hair growth and offering a target for hair loss treatments.
research Proteomics as a Tool to Improve Novel Insights into Skin Diseases: What We Know and Where We Should Be Going
Proteomics combined with other technologies can lead to a better understanding of skin diseases.
research Research Techniques Made Simple: Zebrafish Models for Human Dermatologic Disease
Zebrafish are useful for studying and developing treatments for human skin diseases.
research Wound Healing With Topical BRAF Inhibitor Therapy in a Diabetic Model Suggests Tissue Regenerative Effects
A topical BRAF inhibitor, vemurafenib, can speed up wound healing and promote hair growth, especially in diabetic patients.
research Aging Skin and Non-Surgical Procedures: A Basic Science Overview
Non-surgical procedures can help reduce wrinkles and stimulate skin repair by understanding skin aging at the molecular level.
research Lrig1 Expression in Human Sebaceous Gland Tumors
Lrig1 could be a marker for advanced sebaceous carcinoma.
research Characteristics of KRT80 and Its Roles in Neoplastic Diseases
KRT80 may worsen cancer by increasing growth and spread, but its full effects on treatment and outcomes need more research.
research Adipose-Derived Stem Cells in Skin Diseases, Wound Healing, and Skin Defects: A Review
Fat-derived stem cells show promise for treating skin issues and improving wound healing, but more research is needed to confirm the best way to use them.
research Apoptosis in Hair and Skin: A Review
The study concludes that regulating apoptosis could lead to new treatments for various skin and hair conditions.
research Vitamin A Resolves Lineage Plasticity to Orchestrate Stem Cell Lineage Choices
Vitamin A helps skin stem cells decide their function, aiding in hair growth and wound repair.
research The Role of MicroRNA, Long Non-Coding RNA, and Circular RNA in the Pathogenesis of Polycystic Ovary Syndrome: A Literature Review
MicroRNAs could be key biomarkers and therapeutic targets for PCOS.