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This review discusses the use of human-to-mouse xenografting to study human skin processes in vivo, highlighting its importance for understanding skin regeneration and pathology while identifying knowledge gaps and challenges in applying these findings to human skin.

This review discusses the role of extracellular vesicles in wound healing and explores their potential applications in skin repair and treatment of dermal diseases, reporting no new clinical findings.

This review examines the genetic challenges in improving wool and cashmere fibers, emphasizing the need for further research on wool keratins and keratin-associated proteins to enhance fiber characteristics.

This study explores the regulatory effects of ursolic acid on macrophage function and suggests potential for developing new anti-inflammatory and immunomodulatory drugs, though further research is needed for clinical applications.

This study highlighted the effectiveness of HT-scCAT-seq as a tool for understanding gene regulation in single cells, offering insights into embryonic skin development and proposing a framework for exploring regulatory mechanisms in various biological and disease contexts.

In a study conducted on mice, researchers observed that exposure to ionizing radiation led to significant metabolic imbalances, including dyslipidemia and disruptions in amino acid metabolism, with activated protein C providing partial protection by normalizing certain plasma metabolites and lipids.

This study presents a new method called scMC that effectively distinguishes biological from technical variation in single-cell genomics datasets, demonstrating its ability to accurately align and detect biological signals across various experiments.

This review discusses drug repurposing strategies for rare diseases, highlighting methodologies, achievements, and challenges, but reports no new clinical results.

This study identified thousands of variant-metabolite associations in the human plasma metabolome, offering insights into the genetic bases of metabolism and potential adverse drug effects.

This study introduces scINSIGHT, a method that showed improved performance over existing approaches in identifying gene expression patterns and cellular processes in heterogeneous scRNA-seq datasets from different biological conditions.

This study found that citrullinated proteins, which are implicated in rheumatoid arthritis, were abundant in outer membrane vesicles from Porphyromonas gingivalis but nearly absent in mutants, validating their approach to citrullinated peptide identification.

This study found that mesenchymal stem cells derived from dental pulp and adipose tissue have distinct gene expression signatures that suggest potential target diseases for clinical applications.

This review discusses recent findings on wound healing with a focus on adipose tissue biology and obesity, but presents no new clinical results.

This review synthesizes recent research on how Wnt signaling regulates skin, hair follicle, and nail regeneration, highlighting its compartment-specific roles and discussing targeted strategies for treating conditions like alopecia, chronic wounds, and skin cancer.

This review highlights that Trigonella foenum-graecum L. (fenugreek) shows promise as a versatile plant-based ingredient in cosmetics due to its phytochemicals, which offer benefits for skin and hair care, although further research is necessary for robust validation.

In this study, a computational analysis of promoter regions in human fertility-related genes identified several new candidate regulatory motifs, but these require further experimental validation due to the limitations of being an in silico examination.

This study reported that machine learning analysis of protein profiles in hair segments achieved high accuracy in distinguishing women with non-suicidal self-injury disorder from healthy controls, suggesting hair proteomics as a promising non-invasive biomarker for stress-related psychopathology with potential clinical applications.

The researchers in this study found that neonatal mouse skin fibroblasts show distinct chromatin landscapes directing differentiation into dermal papilla or adipocyte lineages, and such plasticity may inform strategies for enhancing regenerative capacities in adult skin.

This study found that the microRNAs oar-miR-23b and oar-miR-133 inhibit the proliferation and migration of sheep dermal fibroblasts, impacting the development of hair follicles in superfine wool sheep by targeting the genes TGFβ2 and NOTCH1.

This study identified genetic differences between Australian White Sheep and Hu Sheep that may explain their distinct pelage types, with a focus on subcutaneous adiposity and immunoregulation. The findings suggest potential targets for breeding climate-resilient sheep, enhancing our understanding of heat tolerance in these breeds.

This review explores the cellular mechanisms of tissue repair and discusses how advancements in understanding wound pathology could lead to the development of more effective therapies for chronic, non-healing wounds, which are prevalent among individuals with diabetes and aging.

This review discusses how various nutrients, such as flavonoids, probiotics, and omega-3 fatty acids, may support brain health by targeting stress-related pathways, potentially offering protective effects against neurodegenerative and psychiatric disorders through their roles in oxidative stress reduction and neuroinflammation regulation.

This review summarizes the roles of various cells and signaling pathways in skin wound healing, highlights deviations leading to pathological outcomes like chronic wounds, and evaluates cutting-edge approaches such as biomaterials and precision medicine to improve healing and intervention strategies.

This review summarizes recent advances in alopecia management, focusing on combining synthetic and herbal therapies with innovative drug delivery systems like nanocarriers to enhance effectiveness and reduce side effects, while noting challenges with skin penetration and bioavailability.

This study demonstrated that Periplaneta americana extract significantly promoted hair regeneration in depilated mice by enhancing superoxide dismutase activity, upregulating vascular endothelial growth factor, modulating the FOXO/PI3K/AKT pathway, and restoring skin microbiome balance, suggesting its potential as a novel therapeutic candidate for alopecia.

This review highlights that drug repositioning offers a cost-effective alternative to traditional drug discovery, especially for treating orphan and resistant diseases like COVID-19, by repurposing existing drugs such as Hydroxychloroquine and Remdesivir.

In this study, nitrogen starvation in Chlorella sp. FC2 IITG led to increased lipid accumulation by altering the expression of enzymes involved in various metabolic pathways, suggesting potential for genetic engineering of microalgae.

This study found significantly lower serum vitamin D concentrations in patients with alopecia areata compared to healthy controls, suggesting that vitamin D deficiency may be a risk factor for this autoimmune hair loss disease.

This study expands knowledge of non-coding RNAs in goats and other mammals, enhancing understanding of their roles in hair follicle growth and regression.

This study describes a method to isolate and analyze young and mature type VI trichomes from wild tomato species using autofluorescence-based cell sorting.