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March 2022 in “Clinical and Experimental Obstetrics & Gynecology” This study found that in Korean women with polycystic ovary syndrome, higher ovarian volumes were significantly associated with increased serum levels of free testosterone, total testosterone, and 17-alpha-hydroxyprogesterone.
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August 2012 in “Journal der Deutschen Dermatologischen Gesellschaft” A woman's hyperandrogenism was caused by a genetic mutation leading to non-classic adrenogenital syndrome.
March 2025 in “Institutional Repositories DataBase (IRDB)” The testes significantly contribute to vitamin D metabolism and may affect male reproductive health and conditions like hair loss.
This study reports that their population showed significant prevalence of vitamin D deficiency, but the impact of supplementation on pregnancy rates remains unclear and requires more research.
December 2024 in “American Journal of Case Reports” This case report highlights that insulin resistance in PCOS can occur even in underweight patients, as demonstrated by a 24-year-old woman who improved her menstrual cycle, acne, and hirsutism with metformin and dexamethasone over 6 months.
October 2024 in “Journal of the Endocrine Society” This case report details a diagnostic challenge in a postmenopausal woman with severe hyperandrogenism where distinguishing between adrenal and ovarian causes was complicated by elevated 17-OH Progesterone and asymmetric ovarian enlargement; pending surgical pathology is expected to guide further management.
September 2024 in “Medicine theory and practice” In a clinical case study, researchers identified adrenocortical adenoma as the cause of hyperandrogenism syndrome in a preschool-aged girl, following a comprehensive diagnostic process and successful surgical intervention to remove the tumor, leading to positive clinical improvements.
In this case study, a 12-month-old girl presenting with apyretic seizure and congenital alopecia was diagnosed with hereditary vitamin D-resistant rickets, highlighting the importance of comprehensive evaluation for accurate diagnosis.
November 2023 in “Journal of Cosmetic Dermatology” This study found that patients with non-scarring alopecia, such as androgenetic alopecia and female pattern hair loss, have lower serum levels of 25-hydroxyvitamin D and a higher incidence of vitamin D deficiency compared to healthy controls.
May 2023 in “Vestnik dermatologii i venerologii” In this study, researchers examined men with early-stage androgenetic alopecia and found distinct patterns of hair loss correlated with genetic and hormonal factors, noting that parietal region pattern hair loss responded better to minoxidil and micronutrient treatment compared to occipital region pattern.
November 2022 in “Scientific Reports” This study found that ESR1 gene polymorphisms may be linked to hormonal imbalances in young women with hyperandrogenism, potentially affecting bone mineral density indirectly.
November 2022 in “Journal of the Endocrine Society” In this case study, a woman with high 25(OH)D levels and persistent symptoms showed decreased parathormone after transdermal estrogen therapy, highlighting the importance of assessing both parathormone and estrogen levels in similar patients.
November 2022 in “Journal of the Endocrine Society” This case report describes a 23-year-old woman with an adult granulosa cell tumor of the ovary, whose symptoms and hormone levels improved significantly after surgical removal of the tumor.
October 2021 in “International Journal of Research in Dermatology” This study found that individuals with alopecia areata had significantly lower vitamin D levels compared to healthy controls, and lower vitamin D levels were associated with more severe hair loss.
January 2021 in “Medical Research Archives” This study observed that 25-hydroxyvitamin D3 restored rickets symptoms in genetically modified rats, suggesting its direct action through vitamin D receptor pathways.
September 2020 in “International Journal of Research in Medical Sciences” This study found that individuals with alopecia areata had significantly lower serum vitamin D levels compared to healthy controls, but no significant link between vitamin D levels and disease severity was observed.
April 2020 in “Journal of the Endocrine Society” This case report describes a rare occurrence of giant bilateral adrenal myelolipomas in a 28-year-old female with CAH, emphasizing that large, hormonally active, or painful myelolipomas should be surgically removed.
April 2020 in “Journal of the Endocrine Society” This case report describes a 22-year-old woman with hirsutism and irregular menstrual bleeding, diagnosed with an ovarian steroid cell tumor (NOS), whose androgen levels normalized after surgery.
February 2020 in “Open Access Macedonian Journal of Medical Sciences” In this case report, treatment with corticosteroids improved both clinical symptoms and hormonal imbalances in a 27-year-old woman diagnosed with non-classic congenital adrenal hyperplasia.
January 2020 in “Journal of quality in health care & economics” This study found that all participating depressed women in the sample had vitamin D deficiency or insufficiency, suggesting a possible association between vitamin D levels and depression among women in Iraq.
April 2019 in “Journal of Investigative Dermatology” This study found that CYP11A1-derived vitamin D3 analogs inhibit fibroblast proliferation and decrease collagen production through VDR expression, showing potential antifibrotic and antiproliferative activity in human dermal fibroblasts.
January 2019 in “Egyptian Journal of Dermatology and Venereology /Egyptian Journal of Dermatology and Venerology” This study found that patients with alopecia areata had significantly lower serum 25(OH)D levels, which may be associated with increased disease severity.
January 2017 in “Clinical & medical biochemistry” This study observed that Greek Caucasian women with PCOS had distinct serum hormone levels and a specific AKT2 gene SNP, which may play a role in the condition's characteristics.
December 2013 in “대한피부과학회지” In this study, Korean women with female pattern hair loss were found to have higher levels of ferritin, testosterone, and vitamin D compared to the average Korean adult women.
October 2013 in “Handbook of Metabolic Pathways of Xenobiotics” This study found that after oral administration of finasteride in healthy volunteers, the drug was extensively metabolized, with the majority being excreted as metabolites in urine and feces.
January 2008 in “Journal für Kardiologie (Krause & Pachernegg GmbH)” Healthy aging can be promoted through physical activity, lifestyle changes, and certain treatments.
October 2007 in “Clinical Biochemistry” This study identified a new genotype, V281+I172N/V281L, linked to non-classical 21-hydroxylase deficiency, suggesting it should be considered in genetic panels for the condition.
January 1999 in “Salina: revista de lletres” In this case study, a woman with non-classical adrenal hyperplasia experienced reduced levels of specific adrenal steroids and less scalp hair loss after self-treating with Ashwagandha for six months.
This review discusses contraceptive options for adolescent girls, highlighting potential recommendations and contraindications, and reports no new clinical findings.
June 2025 in “Molecular Genetics & Genomic Medicine” This study found that among children with 21-hydroxylase deficiency, there is a strong correlation between severe genetic variants and clinical outcomes, but the correlation weakens with milder variants, indicating the limitations of relying solely on NGS for diagnosis.