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Martin-Perez et al. show that rapamycin's beneficial effects in a mouse model of Leigh syndrome are linked to the downregulation of protein kinase C.

This source outlines various antiandrogen and androgen inhibitor drugs used to treat cutaneous disorders of hyperandrogenism, detailing their mechanisms, uses, dosages, and side effects, with emphasis on spironolactone, finasteride, dutasteride, and oral contraceptives.

This study demonstrated that in a mouse model of androgenic alopecia, PLGA-DUT/siAR@DPCM nanoparticles effectively delivered drugs to hair follicles, suppressed androgen-related targets, promoted cell proliferation, and showed significant therapeutic effects with minimal adverse effects, suggesting their potential for clinical application.

This review discusses how macro-environmental factors such as intradermal adipose tissue and sex hormones influence hair and feather stem cell niches, suggesting environmental targets for regenerative medicine, but reports no new clinical results.

This study introduces the concept of teloptosis, which influences hair shedding during the telogen phase and affects hair density, highlighting that early or delayed teloptosis has noticeable effects.

This study found that overexpression of the transcription factor Tcf3 accelerates keratinocyte migration and skin wound healing in mice, highlighting its potential as a therapeutic target for wound repair.

In this study, epidermal Notch activation increased jagged 1 expression, leading to skin changes like thickening and blistering, with these effects inhibited when jagged 1 was absent.

This study suggests that alterations in copper metabolism may play a key role in the development of androgenetic alopecia in women, presenting potential targets for treatment strategies.

In this study, researchers found that finasteride inhibits progesterone synthesis by blocking cholesterol side-chain cleavage in mouse-derived MA-10 Leydig cells, but this effect may not be evident in human or rat cells.

This study found that overexpressing the gene Thymosin β4 (Tβ4) can promote the growth and development of secondary hair follicle dermal papilla cells in cashmere goats, suggesting its potential as a target for increasing cashmere production.

This review discusses the effects of the epidermal growth factor receptor system on skin biology and pathology, relying on animal models to analyze roles in cellular processes, wound healing, and tumorigenesis, but reports no new results.

The authors suggest that the neuroendocrine system of the skin represents a promising target for repurposing drugs, such as cannabidiol and fingolimod, as topical treatments for inflammatory skin diseases.

In this study, pregnenolone was found to dose-dependently reduce L-DOPA-induced dyskinesias in a rat model of Parkinson's disease, suggesting its potential as a therapeutic target for these dyskinesias.

This review discusses Amphiregulin (AREG) as a potential target for treating fibrotic disorders and cancer, highlighting its role in disease progression and promising results in preclinical studies and early trials.

This review discusses the multifunctional role of PKM2 in promoting cardiac repair and regeneration, highlighting its potential as a therapeutic target in cardiovascular medicine, but reports no new experimental results.

Injecting lentiviral vectors into early gestation mice effectively targets skin stem cells for potential gene therapy.

This review highlights the potential of amphiregulin as a therapeutic target, noting its role in both fibrotic and malignant diseases, and discusses promising early findings but reports no new clinical results.

This review highlights various treatments for androgenetic alopecia that target its underlying pathophysiological mechanisms, reporting enhanced hair growth, especially when combining drugs, which shows improved outcomes over individual drug use alone.

This study highlights the potential of GPR30 and its selective agonists as promising therapeutic targets for treating hair loss disorders and conditions that respond to estrogen, emphasizing their role in modulating hair growth.

This review explores the role of Granzyme B in autoimmune skin diseases and highlights its potential as a therapeutic target due to its involvement in impaired barrier function and inflammation.

This study reported that a novel cationic liposome formulation for delivering encapsulated Cas9 protein and sgRNA successfully decreased SRD5α2 mRNA expression by 29.7% in vitro, suggesting a potential alternative treatment option for conditions like prostate cancer and benign prostatic hyperplasia without current drug side effects.

This review discusses the data resources and computational models used in drug repositioning, highlighting their role in discovering unknown drug mechanisms and reports no new empirical results.

This study found that PRMT5 inhibitors showed potent anti-tumor activity in models of adenoid cystic carcinoma and that combining these inhibitors with lenvatinib may have additional growth-inhibitory effects.

This study identified downstream genes regulated by androgen receptor signaling in dermal papilla cells and suggests potential molecular targets for treating androgenetic alopecia and prostate cancer.

This study found that activation or inhibition of Wnt/β-catenin and Notch signaling pathways in rats can alter wound healing, possibly by affecting epidermal stem cell activity and keratinocyte behavior.

This study found that brain-derived neurotrophic factor (BDNF) inhibited hair shaft elongation and induced premature catagen development in cultured human hair follicles, partially through transforming growth factor β2.

This study found that thrombospondin-1 plays a critical role in hair follicle cycle regulation, with deficiency prolonging follicle growth and overexpression delaying it through antiangiogenic effects.

This review discusses the role of estrogens in hair follicle cycling and the skin, highlighting the need for more research on estrogen signaling pathways and their interactions with other factors in hair biology.

This review examines mesotherapy for local fat reduction, detailing its mechanisms, safety concerns, and the need for research toward FDA-approved uses, but reports no new clinical findings.

This review examines the outcomes of treating Brazilian patients with alopecia universalis using tofacitinib and highlights the need for randomized controlled trials to determine optimal dosing and duration.