18 citations,
January 1996 in “Gynecologic and obstetric investigation” The oral contraceptive alone is the preferred treatment for hirsutism, as adding the GnRH analog showed no significant benefit.
6 citations,
January 2017 in “Annals of Dermatology” Combination of 17α-estradiol and minoxidil improves hair growth and reduces hair loss in most patients.
Hair and nails can show hormone changes during puberty in dogs.
June 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” 17α-estradiol extends lifespan and improves metabolism in male mice through the estrogen receptor α.
February 2020 in “İstanbul medical journal” Metformin improves early signs of heart disease in women with PCOS and raises apelin levels, but doesn't significantly change artery thickness.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” 17β-estradiol may help hair growth by increasing cannabinoid receptor type 1.
37 citations,
July 1980 in “PubMed” Hair lotions with 17 alpha-estradiol can reduce hair loss but won't regrow new hair.
4 citations,
December 2021 in “Clinical and Experimental Reproductive Medicine” Higher estrone-to-estradiol ratios are linked to worse glucose metabolism and insulin resistance in women with PCOS.
18 citations,
April 2009 in “Journal of Chromatography A” The study investigated the persistence of estradiol benzoate and nortestosterone decanoate in cattle hair following treatment with growth promoters, using liquid chromatography-tandem mass spectrometry (LC–MS/MS). The research found that while this method could detect steroid esters in some hair samples, it did not consistently identify all treated animals. Detection was influenced by factors such as the location of hair sampling relative to the injection site, the timing of sampling post-treatment, and the dosage administered. The study highlighted the complexity of steroid ester accumulation in hair, suggesting that it occurs through multiple pathways, including blood, sweat, and sebum. The findings provided insights into the mechanisms of steroid persistence in hair, which could aid in distinguishing between illicit treatment and natural hormone production in cattle.
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36 citations,
October 2016 in “Bone” A male with aromatase deficiency improved bone health with estradiol treatment.
23 citations,
January 2016 in “Transgender health” Hormone therapy with estradiol and spironolactone can regrow scalp hair in transgender women by lowering testosterone to female levels.
13 citations,
December 2018 in “Development, Growth & Differentiation” Sex hormones, especially estradiol, can change chicken feather shapes and colors.
6 citations,
April 2017 in “Journal of Dermatological Science” Ovariectomized mice mimic postmenopausal hair loss, and estradiol helps maintain hair density.
November 2022 in “Journal of the Endocrine Society” A transman experienced lasting virilization symptoms after stopping testosterone, which were resolved with estradiol treatment.
78 citations,
October 2003 in “Cochrane library” Cyproterone acetate with estradiol may subjectively improve excessive hair growth in women, but it's not clinically better than other treatments.
58 citations,
July 1974 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Cyproterone acetate combined with ethinyl estradiol significantly reduced hirsutism in women.
42 citations,
May 2009 in “Contraception” The oral contraceptive with ethinyl estradiol and chlormadinone acetate is effective in treating moderate acne.
January 2008 in “The European Journal of Contraception & Reproductive Health Care” Non-daily contraceptives cause fewer side effects and are more satisfying to women, and certain oral contraceptives can treat acne and seborrhoea, with a combination of chlormadinone acetate and ethinyl estradiol being highly effective and safe.
Cyproterone acetate with ethynyl estradiol significantly improved acne and seborrhea in women, but was less effective for hair loss and excessive hair growth.
154 citations,
October 1996 in “Proceedings of the National Academy of Sciences of the United States of America” Estrogen affects hair growth and skin cell multiplication.
130 citations,
September 1990 in “Journal of the American Academy of Dermatology” Flutamide effectively reduced excessive hair growth and improved related symptoms in hirsutism patients without significant side effects.
125 citations,
January 1999 in “Drugs” Finasteride effectively treats baldness but may cause sexual side effects.
124 citations,
September 1980 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Spironolactone is effective in treating excessive hair growth in women.
123 citations,
December 1997 in “Calcified Tissue International” Higher androgen levels and site-specific AR expression cause sex-related skeletal differences, and certain steroids can boost AR expression and androgen effects in bone cells.
105 citations,
June 2010 in “The journal of sexual medicine” Testosterone undecanoate increases lean mass and causes various physical changes in female-to-male transsexuals.
74 citations,
February 2018 in “Stroke” Women have unique stroke risks due to hormones, contraceptives, pregnancy, and menopause.
66 citations,
October 2013 in “Current Opinion in Endocrinology, Diabetes and Obesity” The conclusion is that published guidelines are improving transgender medical care, but more research and education in transgender medicine are needed.
66 citations,
November 2001 in “European journal of endocrinology” Low SHBG and high FAI, FT, and DHEAS levels are effective in identifying PCOS.