489 citations,
November 2021 in “Signal Transduction and Targeted Therapy” The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.
142 citations,
March 2019 in “Molecules/Molecules online/Molecules annual” Cannabinoids may help treat various skin conditions.
136 citations,
July 2014 in “Proceedings of the National Academy of Sciences of the United States of America” FGF5 gene mutations cause unusually long eyelashes by affecting hair growth regulation.
136 citations,
April 2010 in “British Journal of Dermatology” Acitretin is effective for severe skin conditions but has significant side effects and requires careful monitoring.
87 citations,
December 2015 in “Cochrane library” No single treatment is clearly effective for central serous chorioretinopathy.
81 citations,
February 2016 in “Veterinary pathology” Progeroid mouse models show signs of early aging similar to humans, helping us understand aging better.
58 citations,
November 2018 in “Cochrane library” Oral isotretinoin may slightly improve acne but increases the risk of side effects like dry lips and skin; more research is needed to understand its full risks and benefits.
56 citations,
September 2010 in “Veterinary pathology” Certain mouse strains develop a skin condition similar to a human hair loss disease due to genetic defects.
55 citations,
October 2019 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” The review suggests that other immune cells besides CD8+ T cells may contribute to alopecia areata and that targeting regulatory cell defects could improve treatment.
44 citations,
October 2020 in “Arthritis Care & Research” Choosing the right tools is crucial for accurately measuring lupus activity and damage.
44 citations,
July 2012 in “Endocrine Practice” We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.
42 citations,
August 2013 in “International Journal of Women's Health” Female pattern hair loss is caused by multiple factors and while treatments like topical minoxidil, hormone therapy, and low-level light therapy can help, none can fully cure it.
34 citations,
October 2011 in “Journal of the American Academy of Dermatology” Sarcoidosis is more common and severe in Black patients than in Caucasians, requiring early diagnosis and treatment.
29 citations,
April 2000 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry” ICAM-1 helps regulate hair growth cycles and skin remodeling.
23 citations,
March 2017 in “JAAD case reports” The document suggests a possible link between FAM111B gene mutations and increased cancer risk, particularly pancreatic cancer.
22 citations,
May 2019 in “Animals” High hair cortisol levels indicate stress in cows due to poor shelter conditions and health issues.
21 citations,
July 2022 in “Orphanet journal of rare diseases” New treatments for ichthyosis, like protein replacement and gene therapy, show promise and may become standard care.
21 citations,
January 2022 in “Pharmaceutics” Colchicine might help treat different skin diseases, but more research is needed to confirm its effectiveness and safe dosage.
20 citations,
June 2021 in “British Journal of Dermatology” Use antimalarials like hydroxychloroquine for cutaneous lupus, avoid herbal supplements, and focus on lifestyle changes like sun protection.
18 citations,
October 2020 in “Radiation Research” Some drugs may help treat both COVID-19 and radiation injury.
18 citations,
June 2019 in “Clinical research in dermatology” Acne can't be cured but can be managed with treatments like benzoyl peroxide and diet changes; it's costly and can lead to scarring and mental health issues.
16 citations,
October 2023 in “Molecular cancer” New treatments like nanotechnology show promise in improving skin cancer therapy.
15 citations,
January 2023 in “Antioxidants” Oxidative stress plays a significant role in alopecia areata, and new treatments may include JAK inhibitors and antioxidants.
11 citations,
January 2023 in “BioMed Research International” Microbial biosurfactants could be a safer and environmentally friendly alternative to chemical surfactants in cosmetics.
10 citations,
August 2023 in “Advanced Science” Nitric Oxide has potential in medicine, especially for infections and heart treatments, but its short life and delivery challenges limit its use.
10 citations,
September 2021 in “American Journal of Medical Genetics Part A” Woodhouse-Sakati syndrome shows varied symptoms, including hair loss and diabetes, and is common in Qatar due to a specific genetic variant.
9 citations,
June 2017 in “American journal of ophthalmology. Case reports” A new mutation in the CDH3 gene causes hair loss and vision problems in a young girl.
8 citations,
February 2022 in “Vascular Health and Risk Management” Some skin conditions may increase the risk of heart disease, and understanding their connection could lead to better treatments.
8 citations,
December 2015 in “PubMed” Phyllanthus niruri extract may help treat hair loss by promoting hair growth and blocking a hair loss-related enzyme.
7 citations,
May 2022 in “International Journal of Environmental Research and Public Health” Isotretinoin therapy for acne can cause many reversible side effects, mainly mild skin conditions, and patient understanding of these effects can improve treatment adherence.