This study utilized polarized light microscopy to examine hair shafts in ten children with rare genetic disorders, such as Netherton syndrome and ectodermal dysplasia, providing valuable diagnostic insights into hair thickness, composition, and structural irregularities associated with these conditions.
January 2025 in “Drug repurposing” This study reviewed 16 notable drug repurposing patent applications from 2025, highlighting potential new uses such as guanfacine for autonomic dysfunction and disulfiram for subarachnoid hemorrhage survival, though many disclosures lack peer-reviewed studies and no patents are granted.
This literature review reports that mesenchymal stem cell-derived secretome, including conditioned medium and extracellular vesicles, shows promise as an effective treatment for various diseases in animal and human in-vivo models, with ongoing clinical trials and recommendations for future research discussed.
In this study, researchers developed a method to create a synthetic dataset of facial acne images using generative techniques, achieving 97.6% classification accuracy with InceptionResNetv2, which helps overcome privacy concerns in biomedical applications by using anonymized data.
research 22
December 2023 in “Psychiatry Neurology and Medical Psychology” Alopecia can lead to mental health issues, so treatment should address both skin and emotional health.
December 2020 in “Current Sexual Health Reports” This review discusses the role of neurosteroids and androgens throughout different life stages, noting the potential disruptions caused by 5α-reductase inhibitors like finasteride, but no new clinical results are reported.
This study found that neonatal administration of finasteride reduced sensitivity to alcohol's motor-stimulating effects and increased preference for novelty and initial alcohol consumption in rats, suggesting a role in alcohol vulnerability.
November 2020 in “Psychoneuroendocrinology” In this study, repeated finasteride administration was associated with decreased social interaction and cognitive deficits in male rats, potentially linked to changes in cholinergic system activity.
February 2023 in “International Journal of Multimedia Computing” In this study, improved hidden Markov algorithms based on Bayesian methods enhanced the resolution and segmentation accuracy of low-dose CT images significantly more than naive Bayesian methods.
343 citations
,
December 2008 in “Endocrine Reviews” This review discusses the various evidence-based and potential applications of metformin in treating and preventing symptoms and complications associated with polycystic ovary syndrome but reports no new clinical results.
251 citations
,
October 2014 in “The Journal of Clinical Endocrinology & Metabolism” The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.
237 citations
,
January 2010 in “The Journal of Sexual Medicine” The authors updated recommendations on diagnosing and treating women's sexual dysfunctions, emphasizing a comprehensive assessment approach, while noting the need for further multidisciplinary research.
177 citations
,
July 2004 in “The Journal of Sexual Medicine” This review provides updated guidelines for diagnosing and managing women's sexual dysfunctions but reports no new clinical findings; it emphasizes the need for ongoing research and long-term outcome studies.
144 citations
,
September 2006 in “Clinics in Dermatology” This article outlines manifestations of systemic lupus erythematosus, noting rapid joint symptom improvement with corticosteroids and antimalarial drug responsiveness for skin symptoms, and links anti-Ro with photosensitive rash and subacute lupus.
142 citations
,
September 2020 in “Journal of neurophysiology” This study estimates that young adults have about 230,000 tactile afferent fibers innervating their skin, with density varying by region and decreasing with age.
82 citations
,
August 2006 in “Pharmacology, Biochemistry and Behavior” This review proposes focusing on relationships between neuroactive steroids and psychiatric disorder symptoms, rather than relying on traditional disorder classifications, and reports no new clinical findings.
77 citations
,
August 2025 in “Signal Transduction and Targeted Therapy” This review highlights the potential of extracellular vesicle-based therapies for treating various diseases, but it also notes challenges like the lack of regulatory guidelines that hinder their clinical development.
62 citations
,
September 1974 in “Academy of Management Journal” This article discusses the need for organizational scholars to shift focus from big business organizations to everyday events and places, but it reports no new empirical results.
36 citations
,
October 2016 in “Medical mycology” This study at Mbarara University of Science and Technology found that T. violaceum is the most common cause of tinea capitis in children in Western Uganda, and systemic therapy is preferred over topical treatments for effective management due to the nature of the infection.
27 citations
,
March 2013 in “Social Semiotics” This study analyzes how commercial websites for Propecia depict male hair loss and promote medical treatment, suggesting they contribute to medicalizing a natural condition for profit.
26 citations
,
April 2011 in “Skin Research and Technology” This study found that in vivo confocal scanning laser microscopy accurately quantifies neogenic hair follicles in mice, producing results similar to histology while avoiding fixation artifacts.
19 citations
,
October 2024 in “BMC Medical Informatics and Decision Making” This study used machine learning models to analyze PCOS symptoms for early diagnosis, finding Support Vector Machine and VGG16 algorithms achieved high accuracy rates of 94.44% and 98.29% respectively.
15 citations
,
November 2015 in “Journal of Cosmetic Dermatology” This study reviews existing literature on botanicals for androgenetic alopecia, noting a growing interest and emphasizing research on hair growth stimulants, especially involving green tea and other specific botanicals.
13 citations
,
November 2013 in “Journal of Endocrinology/Journal of endocrinology” This study found that the vitamin D receptor, but not its ligand, regulates genes involved in hair cycle progression, suggesting a role in integrating hormone signaling pathways for hair and epidermal functions.
11 citations
,
July 2017 in “Expert Opinion on Investigational Drugs” This review discusses current and emerging therapeutic strategies for androgenetic alopecia, noting limited evidence but suggesting areas such as prostaglandin analogs, PRP, and progenitor cell therapies as promising future directions.
10 citations
,
September 2020 in “Computational and Mathematical Methods in Medicine” This paper introduces an algorithm for using smart device-mounted microscopes to analyze scalp images and diagnose hair loss by extracting specific hair loss features.
10 citations
,
May 2018 in “Forensic Science International” This study concluded that the process of mummification disfigures facial features, making identification challenging, but commercial shrunken heads retain more defining features compared to ceremonial ones.
10 citations
,
August 2002 in “Sexualities” This article reviews and critiques Tamsin Wilton's arguments on MTF transsexualism, suggesting her work reaffirms Cartesian dualism rather than dismantling it, and emphasizes the need for continued dialogue in transsex, lesbian, and feminist communities.
7 citations
,
January 1996 in “In Practice” This article highlights causes of otitis externa in small animals and proposes an investigative approach; it reports no new findings.
6 citations
,
September 2019 in “Archives of Dermatological Research” In this study, researchers identified 32 differentially expressed genes involved in androgenetic alopecia, with down-regulated genes associated with Wnt and TGF-beta signaling and up-regulated genes linked to oxidative stress pathways.