125 citations,
August 2020 in “Frontiers in Immunology” Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.
78 citations,
August 2012 in “Human molecular genetics online/Human molecular genetics” A new gene, JMJD1C, may affect testosterone levels in men.
75 citations,
January 1995 in “American journal of primatology” Vervet monkeys show physical changes like hair loss and scrotal color changes due to stress or nutrition issues.
67 citations,
May 2007 in “Journal of Cosmetic Dermatology” The herbal formulation promoted hair growth faster and more effectively than minoxidil in rats.
60 citations,
February 2013 in “Cell reports” The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.
47 citations,
August 2016 in “Fitoterapia” Some herbs and their components might help treat hair loss by affecting various biological pathways, but more research and regulation are needed.
46 citations,
March 2001 in “Journal of endocrinological investigation” 5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.
42 citations,
January 2021 in “Journal of Clinical Medicine” Microneedle arrays with nanotechnology show promise for painless drug delivery through the skin but need more research on safety and effectiveness.
39 citations,
March 2009 in “Clinics in plastic surgery” Injection lipolysis effectively reduces small fat deposits and should be done with care and proper patient selection.
35 citations,
February 2006 in “Textile Research Journal” Enzymes xylanase and pectinase clean wool and specialty hair fibers effectively without damage, offering an eco-friendly alternative to soap and hot water.
28 citations,
May 2012 in “Veterinary Dermatology” Different types of dog hair loss are linked to problems starting the hair growth phase and early hair cycle ending.
26 citations,
May 2013 in “Marine Drugs” Ishige sinicola, a type of seaweed, may help hair grow by blocking a hair loss-related enzyme and boosting important cell growth.
25 citations,
July 2017 in “Archives of Dermatological Research” Herbal products might promote hair growth with fewer side effects, but more research is needed to confirm their safety and effectiveness.
24 citations,
July 2017 in “Structure” FGF9 controls which receptors it binds to through a process where two FGF9 molecules join, and changes in FGF9 can lead to incorrect receptor activation.
21 citations,
March 2017 in “Skin research and technology” Removing external lipids from hair reduces moisture and increases strength, while removing internal lipids decreases water permeability.
20 citations,
December 1995 in “Journal of Chromatography B: Biomedical Sciences and Applications” Accurate method measures finasteride levels in human plasma using gas chromatography-mass spectrometry.
17 citations,
June 2017 in “Journal of pharmaceutical sciences” Researchers developed a nanomedicine for acne treatment that delivers medication with less irritation and is non-irritating for oily skin.
16 citations,
November 2020 in “International journal of pharmaceutics” Using longer PEG chains helps nanoparticles penetrate hair follicles better, improving drug delivery for conditions like alopecia.
15 citations,
November 2015 in “Journal of Cosmetic Dermatology” Botanicals like green tea extract show potential for hair growth, but more research is needed.
13 citations,
January 2015 in “Molecular Pharmaceutics” Minoxidil works well as a high permeability reference drug for biopharmaceutics classification.
11 citations,
January 2018 in “RSC Advances” Cedrol cream is more effective and safe for promoting hair growth than traditional treatments.
9 citations,
July 2017 in “Journal of Drug Delivery Science and Technology” Scientists developed a new method to deliver alopecia treatment directly to hair follicles, which could be a promising treatment for hair loss and other hair diseases.
9 citations,
March 2017 in “Dermatologic Surgery” Asian men with hair loss have different follicular densities: East/Southeast 61.1, South 63.5, West 63.6 FU/cm².
9 citations,
September 2009 in “The Prostate” Finasteride doesn't improve survival in LNCaP tumor model during off-cycle of therapy.
7 citations,
July 2019 in “International Journal of Molecular Sciences” PGA-4HGF may help treat hair loss by activating hair growth pathways and extending the hair growth phase.
7 citations,
March 2019 in “Journal of cosmetic dermatology” African hair has the most lipids, while Caucasian hair is more hydrated and stronger.
5 citations,
September 2012 in “Springer eBooks” Nanoparticles can be used to deliver drugs to hair follicles, potentially improving treatments for conditions like acne and alopecia, and could also be used for vaccine delivery and gene therapy.
2 citations,
July 2009 in “Pharmacognosy Research” A herbal mix with chickpea, holy basil, and nut grass extracts grew rat hair well, similar to a common hair growth drug.
1 citations,
April 2016 in “Journal of Investigative Dermatology” Blocking Prostaglandin D₂ may help treat hair loss.
Blocking the Mitochondrial Pyruvate Carrier causes stress in hair follicles, which can be reduced by an ISR inhibitor.