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Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.

Colorectal cancer development involves both genetic changes and epigenetic alterations like DNA methylation and microRNA changes.

Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.

MSC-Exos can aid organ development and offer therapeutic benefits for various conditions.

Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.

Plant extracts can help prevent hair loss and promote hair growth.

High levels of testosterone and 5α-DHT can lead to cell death in cells important for hair growth.

A specific hair protein variant increases the spread of breast cancer and is linked to worse survival rates.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Products should be called 'sperm-safe' only after thorough, well-designed tests.

The document concludes that more research is needed to reduce frequent hospital visits, addiction medicine education improves with specific training, early breast cancer surgery findings are emerging, nipple smears are not very accurate, surgery for older melanoma patients doesn't extend life, a genetic condition in infants can often be treated with one drug, doctors are inconsistent with blood clot medication, a certain gene may protect against cell damage, muscle gene overexpression affects many other genes, and some mitochondrial genes are less active in mice with tumors.

Genetics play a role in acne, but how exactly they contribute is not fully understood.

Researchers successfully grew horse skin cells that produce pigment from hair follicle samples.

DHT stops hair regrowth in mice, similar to human hair loss.

New therapies are being developed that target integrin pathways to treat various diseases.

Glucocorticoids are powerful anti-inflammatory drugs that must be used carefully to avoid serious side effects.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

Birth control pills increase certain receptor activities in female gerbil prostate glands and can lead to prostate changes.

Keratin fibrils in hair form and stop growing at specific points in the follicle.

Tacrolimus causes fewer acute rejections than cyclosporin A in kidney transplants but doesn't necessarily improve kidney function after one year; cardiovascular risks and side effects vary between the two drugs.

The document explains how male reproductive hormones work and affect the body.

Birth control pills change the activity of certain inflammation and blood clotting genes in women with PCOS.

Androgens are important for normal ovarian function and estrogen production, but may not be the main cause of follicle death.

Clascoterone is a new, effective, and safe acne treatment without systemic side effects.

Different types of cell death affect skin health and inflammation, and understanding them could improve treatments for skin diseases.

Decorin helps hair cells grow and move, and keeps hair growth phase going in mice.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.